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Epidemiology of Unconventional Histological Subtypes of Urethral Cancer

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Epidemiology of Unconventional Histological Subtypes of Urethral Cancer. / Wenzel, Mike; Collà Ruvolo, Claudia; Würnschimmel, Christoph; Nocera, Luigi; Hoeh, Benedikt; Tian, Zhe; Saad, Fred; Briganti, Alberto; Tilki, Derya; Banek, Severiné; Mandel, Philipp; Becker, Andreas; Kluth, Luis A; Chun, Felix K H; Karakiewicz, Pierre I.

In: UROL INT, Vol. 107, No. 1, 2023, p. 15-22.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wenzel, M, Collà Ruvolo, C, Würnschimmel, C, Nocera, L, Hoeh, B, Tian, Z, Saad, F, Briganti, A, Tilki, D, Banek, S, Mandel, P, Becker, A, Kluth, LA, Chun, FKH & Karakiewicz, PI 2023, 'Epidemiology of Unconventional Histological Subtypes of Urethral Cancer', UROL INT, vol. 107, no. 1, pp. 15-22. https://doi.org/10.1159/000525673

APA

Wenzel, M., Collà Ruvolo, C., Würnschimmel, C., Nocera, L., Hoeh, B., Tian, Z., Saad, F., Briganti, A., Tilki, D., Banek, S., Mandel, P., Becker, A., Kluth, L. A., Chun, F. K. H., & Karakiewicz, P. I. (2023). Epidemiology of Unconventional Histological Subtypes of Urethral Cancer. UROL INT, 107(1), 15-22. https://doi.org/10.1159/000525673

Vancouver

Wenzel M, Collà Ruvolo C, Würnschimmel C, Nocera L, Hoeh B, Tian Z et al. Epidemiology of Unconventional Histological Subtypes of Urethral Cancer. UROL INT. 2023;107(1):15-22. https://doi.org/10.1159/000525673

Bibtex

@article{557d41594f054856974234270e81cc81,
title = "Epidemiology of Unconventional Histological Subtypes of Urethral Cancer",
abstract = "INTRODUCTION: The aim of the study was to examine cancer-specific mortality (CSM) of unconventional urethral cancers.METHODS: Within the SEER (2004-2016) database, we analyzed CSM of 165 patients with unconventional urethral-cancer histology. Kaplan-Meier plots were used to test the effect of unconventional histologies in urethral cancer on CSM.RESULTS: Of 165 eligible patients, the Mullerian type accounted for 55 (33.3%) versus melanocytic (26.7%) versus neuroendocrine 25 (15.2%) versus lymphoma 22 (13.3%) versus mesenchymal/sarcoma 15 (9.1%) versus spindle cell 4 (2.1%) patients. Median age at diagnosis was 81 years in spindle cell, 75 in melanocytic, 74 in neuroendocrine and mesenchymal/sarcoma, 67 in lymphoma, and 62 years Mullerian type (p < 0.001). Of all, 116 (70.3%) were female. The Mullerian type exhibited the highest female ratio (96.4%) versus the lowest female ratio in neuroendocrine (24.0%). The Mullerian type was most frequent in African-American females. In Caucasian females, the melanocytic type was most frequent (49.1%). In African-American (38.9%) and Caucasian males (33.3%), neuroendocrine histology was most frequent. Three-year CSM was, respectively, 27.5%, 23.1% 22.3%, 20.5%, and 16.1% for melanocytic, mesenchymal/sarcoma, Mullerian type, neuroendocrine, and lymphoma histology. Median cancer-specific survival was 106 versus 10 months for combined nonmetastatic versus metastatic nonconventional histologies.CONCLUSION: Important age, sex, racial/ethnic group distribution, and survival differences exist between each unconventional urethral-cancer histological subtypes.",
keywords = "Male, Humans, Female, Urethral Neoplasms, SEER Program, Sarcoma/pathology",
author = "Mike Wenzel and {Coll{\`a} Ruvolo}, Claudia and Christoph W{\"u}rnschimmel and Luigi Nocera and Benedikt Hoeh and Zhe Tian and Fred Saad and Alberto Briganti and Derya Tilki and Severin{\'e} Banek and Philipp Mandel and Andreas Becker and Kluth, {Luis A} and Chun, {Felix K H} and Karakiewicz, {Pierre I}",
note = "{\textcopyright} 2022 The Author(s). Published by S. Karger AG, Basel.",
year = "2023",
doi = "10.1159/000525673",
language = "English",
volume = "107",
pages = "15--22",
journal = "UROL INT",
issn = "0042-1138",
publisher = "S. Karger AG",
number = "1",

}

RIS

TY - JOUR

T1 - Epidemiology of Unconventional Histological Subtypes of Urethral Cancer

AU - Wenzel, Mike

AU - Collà Ruvolo, Claudia

AU - Würnschimmel, Christoph

AU - Nocera, Luigi

AU - Hoeh, Benedikt

AU - Tian, Zhe

AU - Saad, Fred

AU - Briganti, Alberto

AU - Tilki, Derya

AU - Banek, Severiné

AU - Mandel, Philipp

AU - Becker, Andreas

AU - Kluth, Luis A

AU - Chun, Felix K H

AU - Karakiewicz, Pierre I

N1 - © 2022 The Author(s). Published by S. Karger AG, Basel.

PY - 2023

Y1 - 2023

N2 - INTRODUCTION: The aim of the study was to examine cancer-specific mortality (CSM) of unconventional urethral cancers.METHODS: Within the SEER (2004-2016) database, we analyzed CSM of 165 patients with unconventional urethral-cancer histology. Kaplan-Meier plots were used to test the effect of unconventional histologies in urethral cancer on CSM.RESULTS: Of 165 eligible patients, the Mullerian type accounted for 55 (33.3%) versus melanocytic (26.7%) versus neuroendocrine 25 (15.2%) versus lymphoma 22 (13.3%) versus mesenchymal/sarcoma 15 (9.1%) versus spindle cell 4 (2.1%) patients. Median age at diagnosis was 81 years in spindle cell, 75 in melanocytic, 74 in neuroendocrine and mesenchymal/sarcoma, 67 in lymphoma, and 62 years Mullerian type (p < 0.001). Of all, 116 (70.3%) were female. The Mullerian type exhibited the highest female ratio (96.4%) versus the lowest female ratio in neuroendocrine (24.0%). The Mullerian type was most frequent in African-American females. In Caucasian females, the melanocytic type was most frequent (49.1%). In African-American (38.9%) and Caucasian males (33.3%), neuroendocrine histology was most frequent. Three-year CSM was, respectively, 27.5%, 23.1% 22.3%, 20.5%, and 16.1% for melanocytic, mesenchymal/sarcoma, Mullerian type, neuroendocrine, and lymphoma histology. Median cancer-specific survival was 106 versus 10 months for combined nonmetastatic versus metastatic nonconventional histologies.CONCLUSION: Important age, sex, racial/ethnic group distribution, and survival differences exist between each unconventional urethral-cancer histological subtypes.

AB - INTRODUCTION: The aim of the study was to examine cancer-specific mortality (CSM) of unconventional urethral cancers.METHODS: Within the SEER (2004-2016) database, we analyzed CSM of 165 patients with unconventional urethral-cancer histology. Kaplan-Meier plots were used to test the effect of unconventional histologies in urethral cancer on CSM.RESULTS: Of 165 eligible patients, the Mullerian type accounted for 55 (33.3%) versus melanocytic (26.7%) versus neuroendocrine 25 (15.2%) versus lymphoma 22 (13.3%) versus mesenchymal/sarcoma 15 (9.1%) versus spindle cell 4 (2.1%) patients. Median age at diagnosis was 81 years in spindle cell, 75 in melanocytic, 74 in neuroendocrine and mesenchymal/sarcoma, 67 in lymphoma, and 62 years Mullerian type (p < 0.001). Of all, 116 (70.3%) were female. The Mullerian type exhibited the highest female ratio (96.4%) versus the lowest female ratio in neuroendocrine (24.0%). The Mullerian type was most frequent in African-American females. In Caucasian females, the melanocytic type was most frequent (49.1%). In African-American (38.9%) and Caucasian males (33.3%), neuroendocrine histology was most frequent. Three-year CSM was, respectively, 27.5%, 23.1% 22.3%, 20.5%, and 16.1% for melanocytic, mesenchymal/sarcoma, Mullerian type, neuroendocrine, and lymphoma histology. Median cancer-specific survival was 106 versus 10 months for combined nonmetastatic versus metastatic nonconventional histologies.CONCLUSION: Important age, sex, racial/ethnic group distribution, and survival differences exist between each unconventional urethral-cancer histological subtypes.

KW - Male

KW - Humans

KW - Female

KW - Urethral Neoplasms

KW - SEER Program

KW - Sarcoma/pathology

U2 - 10.1159/000525673

DO - 10.1159/000525673

M3 - SCORING: Journal article

C2 - 35882213

VL - 107

SP - 15

EP - 22

JO - UROL INT

JF - UROL INT

SN - 0042-1138

IS - 1

ER -