Epidemiological survey of 214 families with bladder exstrophy-epispadias complex.

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Epidemiological survey of 214 families with bladder exstrophy-epispadias complex. / Gambhir, L; Höller, T; Müller, M; Schott, G; Vogt, H; Detlefsen, B; Ebert, A-K; Fisch, Margit; Beaudoin, S; Stein, R; Boyadjiev, S A; Gearhart, J P; Rösch, W; Utsch, B; Boemers, T M; Reutter, H; Ludwig, M.

In: J UROLOGY, Vol. 179, No. 4, 4, 2008, p. 1539-1543.

Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

Harvard

Gambhir, L, Höller, T, Müller, M, Schott, G, Vogt, H, Detlefsen, B, Ebert, A-K, Fisch, M, Beaudoin, S, Stein, R, Boyadjiev, SA, Gearhart, JP, Rösch, W, Utsch, B, Boemers, TM, Reutter, H & Ludwig, M 2008, 'Epidemiological survey of 214 families with bladder exstrophy-epispadias complex.', J UROLOGY, vol. 179, no. 4, 4, pp. 1539-1543. <http://www.ncbi.nlm.nih.gov/pubmed/18295266?dopt=Citation>

APA

Gambhir, L., Höller, T., Müller, M., Schott, G., Vogt, H., Detlefsen, B., Ebert, A-K., Fisch, M., Beaudoin, S., Stein, R., Boyadjiev, S. A., Gearhart, J. P., Rösch, W., Utsch, B., Boemers, T. M., Reutter, H., & Ludwig, M. (2008). Epidemiological survey of 214 families with bladder exstrophy-epispadias complex. J UROLOGY, 179(4), 1539-1543. [4]. http://www.ncbi.nlm.nih.gov/pubmed/18295266?dopt=Citation

Vancouver

Gambhir L, Höller T, Müller M, Schott G, Vogt H, Detlefsen B et al. Epidemiological survey of 214 families with bladder exstrophy-epispadias complex. J UROLOGY. 2008;179(4):1539-1543. 4.

Bibtex

@article{acba15fe30a641af87866b3224205fc8,
title = "Epidemiological survey of 214 families with bladder exstrophy-epispadias complex.",
abstract = "PURPOSE: We sought to identify causative nongenetic and genetic risk factors for the bladder exstrophy-epispadias complex. MATERIALS AND METHODS: A total of 237 families with the bladder exstrophy-epispadias complex were invited to participate in the study, and information was obtained from 214 families, mainly from European countries. RESULTS: Two families showed familial occurrence. Male predominance was found among all subgroups comprising epispadias, classic bladder exstrophy and cloacal exstrophy, with male-to-female ratios of 1.4:1, 2.8:1 and 2.0:1, respectively (p = 0.001). No association with parental age, maternal reproductive history or periconceptional maternal exposure to alcohol, drugs, chemical noxae, radiation or infections was found. However, periconceptional maternal exposure to smoking was significantly more common in patients with cloacal exstrophy than in the combined group of patients with epispadias/classic bladder exstrophy (p = 0.009). Only 16.8% of mothers followed the current recommendations of periconceptional folic acid supplementation, and 17.6% had started supplementation before 10 weeks of gestation. Interestingly, in the latter group mothers of patients with cloacal exstrophy were more compliant with folic acid supplementation than were mothers of the combined group of patients with epispadias/classic bladder exstrophy (p = 0.037). Furthermore, mothers of children with cloacal exstrophy knew significantly more often prenatally that their child would have a congenital malformation than did mothers of children with epispadias/classic bladder exstrophy (p",
author = "L Gambhir and T H{\"o}ller and M M{\"u}ller and G Schott and H Vogt and B Detlefsen and A-K Ebert and Margit Fisch and S Beaudoin and R Stein and Boyadjiev, {S A} and Gearhart, {J P} and W R{\"o}sch and B Utsch and Boemers, {T M} and H Reutter and M Ludwig",
year = "2008",
language = "Deutsch",
volume = "179",
pages = "1539--1543",
journal = "J UROLOGY",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Epidemiological survey of 214 families with bladder exstrophy-epispadias complex.

AU - Gambhir, L

AU - Höller, T

AU - Müller, M

AU - Schott, G

AU - Vogt, H

AU - Detlefsen, B

AU - Ebert, A-K

AU - Fisch, Margit

AU - Beaudoin, S

AU - Stein, R

AU - Boyadjiev, S A

AU - Gearhart, J P

AU - Rösch, W

AU - Utsch, B

AU - Boemers, T M

AU - Reutter, H

AU - Ludwig, M

PY - 2008

Y1 - 2008

N2 - PURPOSE: We sought to identify causative nongenetic and genetic risk factors for the bladder exstrophy-epispadias complex. MATERIALS AND METHODS: A total of 237 families with the bladder exstrophy-epispadias complex were invited to participate in the study, and information was obtained from 214 families, mainly from European countries. RESULTS: Two families showed familial occurrence. Male predominance was found among all subgroups comprising epispadias, classic bladder exstrophy and cloacal exstrophy, with male-to-female ratios of 1.4:1, 2.8:1 and 2.0:1, respectively (p = 0.001). No association with parental age, maternal reproductive history or periconceptional maternal exposure to alcohol, drugs, chemical noxae, radiation or infections was found. However, periconceptional maternal exposure to smoking was significantly more common in patients with cloacal exstrophy than in the combined group of patients with epispadias/classic bladder exstrophy (p = 0.009). Only 16.8% of mothers followed the current recommendations of periconceptional folic acid supplementation, and 17.6% had started supplementation before 10 weeks of gestation. Interestingly, in the latter group mothers of patients with cloacal exstrophy were more compliant with folic acid supplementation than were mothers of the combined group of patients with epispadias/classic bladder exstrophy (p = 0.037). Furthermore, mothers of children with cloacal exstrophy knew significantly more often prenatally that their child would have a congenital malformation than did mothers of children with epispadias/classic bladder exstrophy (p

AB - PURPOSE: We sought to identify causative nongenetic and genetic risk factors for the bladder exstrophy-epispadias complex. MATERIALS AND METHODS: A total of 237 families with the bladder exstrophy-epispadias complex were invited to participate in the study, and information was obtained from 214 families, mainly from European countries. RESULTS: Two families showed familial occurrence. Male predominance was found among all subgroups comprising epispadias, classic bladder exstrophy and cloacal exstrophy, with male-to-female ratios of 1.4:1, 2.8:1 and 2.0:1, respectively (p = 0.001). No association with parental age, maternal reproductive history or periconceptional maternal exposure to alcohol, drugs, chemical noxae, radiation or infections was found. However, periconceptional maternal exposure to smoking was significantly more common in patients with cloacal exstrophy than in the combined group of patients with epispadias/classic bladder exstrophy (p = 0.009). Only 16.8% of mothers followed the current recommendations of periconceptional folic acid supplementation, and 17.6% had started supplementation before 10 weeks of gestation. Interestingly, in the latter group mothers of patients with cloacal exstrophy were more compliant with folic acid supplementation than were mothers of the combined group of patients with epispadias/classic bladder exstrophy (p = 0.037). Furthermore, mothers of children with cloacal exstrophy knew significantly more often prenatally that their child would have a congenital malformation than did mothers of children with epispadias/classic bladder exstrophy (p

M3 - SCORING: Zeitschriftenaufsatz

VL - 179

SP - 1539

EP - 1543

JO - J UROLOGY

JF - J UROLOGY

SN - 0022-5347

IS - 4

M1 - 4

ER -