Research ExplorerPublicationsEphrinB2-EphB4 Signaling in Neurooncological Disease

EphrinB2-EphB4 Signaling in Neurooncological Disease

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EphrinB2-EphB4 Signaling in Neurooncological Disease. / Piffko, Andras; Uhl, Christian; Vajkoczy, Peter; Czabanka, Marcus; Broggini, Thomas.

In: INT J MOL SCI, Vol. 23, No. 3, 1679, 31.01.2022.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Piffko, A, Uhl, C, Vajkoczy, P, Czabanka, M & Broggini, T 2022, 'EphrinB2-EphB4 Signaling in Neurooncological Disease', INT J MOL SCI, vol. 23, no. 3, 1679. https://doi.org/10.3390/ijms23031679

APA

Piffko, A., Uhl, C., Vajkoczy, P., Czabanka, M., & Broggini, T. (2022). EphrinB2-EphB4 Signaling in Neurooncological Disease. INT J MOL SCI, 23(3), [1679]. https://doi.org/10.3390/ijms23031679

Vancouver

Piffko A, Uhl C, Vajkoczy P, Czabanka M, Broggini T. EphrinB2-EphB4 Signaling in Neurooncological Disease. INT J MOL SCI. 2022 Jan 31;23(3). 1679. https://doi.org/10.3390/ijms23031679

Bibtex

@article{b2027865bad04cf2b9534b4b9fb2b400,
title = "EphrinB2-EphB4 Signaling in Neurooncological Disease",
abstract = "EphrinB2-EphB4 signaling is critical during embryogenesis for cardiovascular formation and neuronal guidance. Intriguingly, critical expression patterns have been discovered in cancer pathologies over the last two decades. Multiple connections to tumor migration, growth, angiogenesis, apoptosis, and metastasis have been identified in vitro and in vivo. However, the molecular signaling pathways are manifold and signaling of the EphB4 receptor or the ephrinB2 ligand is cancer type specific. Here we explore the impact of these signaling pathways in neurooncological disease, including glioma, brain metastasis, and spinal bone metastasis. We identify potential downstream pathways that mediate cancer suppression or progression and seek to understand it´s role in antiangiogenic therapy resistance in glioma. Despite the Janus-faced functions of ephrinB2-EphB4 signaling in cancer Eph signaling remains a promising clinical target.",
keywords = "Bone Neoplasms/metabolism, Brain Neoplasms/metabolism, Ephrin-B2/metabolism, Humans, Neoplasm Proteins/metabolism, Receptor, EphB4/metabolism, Signal Transduction",
author = "Andras Piffko and Christian Uhl and Peter Vajkoczy and Marcus Czabanka and Thomas Broggini",
year = "2022",
month = jan,
day = "31",
doi = "10.3390/ijms23031679",
language = "English",
volume = "23",
journal = "INT J MOL SCI",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

RIS

TY - JOUR

T1 - EphrinB2-EphB4 Signaling in Neurooncological Disease

AU - Piffko, Andras

AU - Uhl, Christian

AU - Vajkoczy, Peter

AU - Czabanka, Marcus

AU - Broggini, Thomas

PY - 2022/1/31

Y1 - 2022/1/31

N2 - EphrinB2-EphB4 signaling is critical during embryogenesis for cardiovascular formation and neuronal guidance. Intriguingly, critical expression patterns have been discovered in cancer pathologies over the last two decades. Multiple connections to tumor migration, growth, angiogenesis, apoptosis, and metastasis have been identified in vitro and in vivo. However, the molecular signaling pathways are manifold and signaling of the EphB4 receptor or the ephrinB2 ligand is cancer type specific. Here we explore the impact of these signaling pathways in neurooncological disease, including glioma, brain metastasis, and spinal bone metastasis. We identify potential downstream pathways that mediate cancer suppression or progression and seek to understand it´s role in antiangiogenic therapy resistance in glioma. Despite the Janus-faced functions of ephrinB2-EphB4 signaling in cancer Eph signaling remains a promising clinical target.

AB - EphrinB2-EphB4 signaling is critical during embryogenesis for cardiovascular formation and neuronal guidance. Intriguingly, critical expression patterns have been discovered in cancer pathologies over the last two decades. Multiple connections to tumor migration, growth, angiogenesis, apoptosis, and metastasis have been identified in vitro and in vivo. However, the molecular signaling pathways are manifold and signaling of the EphB4 receptor or the ephrinB2 ligand is cancer type specific. Here we explore the impact of these signaling pathways in neurooncological disease, including glioma, brain metastasis, and spinal bone metastasis. We identify potential downstream pathways that mediate cancer suppression or progression and seek to understand it´s role in antiangiogenic therapy resistance in glioma. Despite the Janus-faced functions of ephrinB2-EphB4 signaling in cancer Eph signaling remains a promising clinical target.

KW - Bone Neoplasms/metabolism

KW - Brain Neoplasms/metabolism

KW - Ephrin-B2/metabolism

KW - Humans

KW - Neoplasm Proteins/metabolism

KW - Receptor, EphB4/metabolism

KW - Signal Transduction

U2 - 10.3390/ijms23031679

DO - 10.3390/ijms23031679

M3 - SCORING: Review article

C2 - 35163601

VL - 23

JO - INT J MOL SCI

JF - INT J MOL SCI

SN - 1661-6596

IS - 3

M1 - 1679

ER -