Enhanced trabecular micro-architecture of the femoral neck in hip osteoarthritis vs. healthy controls: a micro-computer tomography study in postmenopausal women
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Enhanced trabecular micro-architecture of the femoral neck in hip osteoarthritis vs. healthy controls: a micro-computer tomography study in postmenopausal women. / Djuric, Marija; Zagorac, Slavisa; Milovanovic, Petar; Djonic, Danijela; Nikolic, Slobodan; Hahn, Michael; Zivkovic, Vladimir; Bumbasirevic, Marko; Amling, Michael; Marshall, Robert Percy.
In: INT ORTHOP, Vol. 37, No. 1, 1, 2013, p. 21-26.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Enhanced trabecular micro-architecture of the femoral neck in hip osteoarthritis vs. healthy controls: a micro-computer tomography study in postmenopausal women
AU - Djuric, Marija
AU - Zagorac, Slavisa
AU - Milovanovic, Petar
AU - Djonic, Danijela
AU - Nikolic, Slobodan
AU - Hahn, Michael
AU - Zivkovic, Vladimir
AU - Bumbasirevic, Marko
AU - Amling, Michael
AU - Marshall, Robert Percy
PY - 2013
Y1 - 2013
N2 - PURPOSE: A controversial relationship between osteoarthritis (OA) and bone fragility has been attracting considerable attention. However, despite interest in the effects of OA on femoral neck fracture risk and numerous studies analysing the changes in the arthritic femoral head, there is insufficient data about femoral neck 3D bone micro-architecture in individuals with hip osteoarthritis. We compared trabecular micro-architecture of the femoral neck between postmenopausal women with coxarthrosis and controls to explore whether coxarthrosis may indicate reduced bone fragility from the trabecular micro-architectural perspective.METHODS: The study sample included nine women with hip osteoarthritis and 13 age-matched controls. The femoral neck sections were scanned using micro-computed tomography, evaluating the cancellous bone from the superolateral and inferomedial neck subregions.RESULTS: Osteoarthritic subjects demonstrated a general trend of improved trabecular micro-architecture in both analysed subregions when compared with age-matched controls. In particular, several architectural properties that are important predictors of cancellous bone strength showed significantly better values in the OA group, even after adjusting for bone volume fraction. Namely, the OA group expressed higher trabecular connectivity (p = 0.008), lower SMI indicating more plate-like structure (p = 0.005), and reduced anisotropy (p = 0.006) particularly in the inferomedial neck. Osteoarthritic cases also trended towards higher BV/TV, particularly in the superolateral neck. All micro-architectural parameters displayed significant regional heterogeneity (p ≤ 0.01), with the inferomedial neck region showing more favourable values than the superolateral region.CONCLUSIONS: Enhanced trabecular micro-architecture of the femoral neck in postmenopausal osteoarthritic subjects suggests reduced cancellous bone fragility in comparison with their age-matched healthy controls.
AB - PURPOSE: A controversial relationship between osteoarthritis (OA) and bone fragility has been attracting considerable attention. However, despite interest in the effects of OA on femoral neck fracture risk and numerous studies analysing the changes in the arthritic femoral head, there is insufficient data about femoral neck 3D bone micro-architecture in individuals with hip osteoarthritis. We compared trabecular micro-architecture of the femoral neck between postmenopausal women with coxarthrosis and controls to explore whether coxarthrosis may indicate reduced bone fragility from the trabecular micro-architectural perspective.METHODS: The study sample included nine women with hip osteoarthritis and 13 age-matched controls. The femoral neck sections were scanned using micro-computed tomography, evaluating the cancellous bone from the superolateral and inferomedial neck subregions.RESULTS: Osteoarthritic subjects demonstrated a general trend of improved trabecular micro-architecture in both analysed subregions when compared with age-matched controls. In particular, several architectural properties that are important predictors of cancellous bone strength showed significantly better values in the OA group, even after adjusting for bone volume fraction. Namely, the OA group expressed higher trabecular connectivity (p = 0.008), lower SMI indicating more plate-like structure (p = 0.005), and reduced anisotropy (p = 0.006) particularly in the inferomedial neck. Osteoarthritic cases also trended towards higher BV/TV, particularly in the superolateral neck. All micro-architectural parameters displayed significant regional heterogeneity (p ≤ 0.01), with the inferomedial neck region showing more favourable values than the superolateral region.CONCLUSIONS: Enhanced trabecular micro-architecture of the femoral neck in postmenopausal osteoarthritic subjects suggests reduced cancellous bone fragility in comparison with their age-matched healthy controls.
KW - Humans
KW - Aged
KW - Female
KW - Case-Control Studies
KW - Statistics, Nonparametric
KW - Analysis of Variance
KW - Postmenopause
KW - Femur Neck/radiography
KW - Osteoarthritis, Hip/radiography
KW - X-Ray Microtomography
KW - Humans
KW - Aged
KW - Female
KW - Case-Control Studies
KW - Statistics, Nonparametric
KW - Analysis of Variance
KW - Postmenopause
KW - Femur Neck/radiography
KW - Osteoarthritis, Hip/radiography
KW - X-Ray Microtomography
U2 - 10.1007/s00264-012-1713-4
DO - 10.1007/s00264-012-1713-4
M3 - SCORING: Journal article
C2 - 23180101
VL - 37
SP - 21
EP - 26
JO - INT ORTHOP
JF - INT ORTHOP
SN - 0341-2695
IS - 1
M1 - 1
ER -
