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Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres

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Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres. / Omairi, Saleh; Matsakas, Antonios; Degens, Hans; Kretz, Oliver; Hansson, Kenth-Arne; Solbrå, Andreas Våvang; Bruusgaard, Jo C; Joch, Barbara; Sartori, Roberta; Giallourou, Natasa; Mitchell, Robert; Collins-Hooper, Henry; Foster, Keith; Pasternack, Arja; Ritvos, Olli; Sandri, Marco; Narkar, Vihang; Swann, Jonathan R; Huber, Tobias B; Patel, Ketan.

In: ELIFE, Vol. 5, 05.08.2016.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Omairi, S, Matsakas, A, Degens, H, Kretz, O, Hansson, K-A, Solbrå, AV, Bruusgaard, JC, Joch, B, Sartori, R, Giallourou, N, Mitchell, R, Collins-Hooper, H, Foster, K, Pasternack, A, Ritvos, O, Sandri, M, Narkar, V, Swann, JR, Huber, TB & Patel, K 2016, 'Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres', ELIFE, vol. 5. https://doi.org/10.7554/eLife.16940

APA

Omairi, S., Matsakas, A., Degens, H., Kretz, O., Hansson, K-A., Solbrå, A. V., Bruusgaard, J. C., Joch, B., Sartori, R., Giallourou, N., Mitchell, R., Collins-Hooper, H., Foster, K., Pasternack, A., Ritvos, O., Sandri, M., Narkar, V., Swann, J. R., Huber, T. B., & Patel, K. (2016). Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres. ELIFE, 5. https://doi.org/10.7554/eLife.16940

Vancouver

Omairi S, Matsakas A, Degens H, Kretz O, Hansson K-A, Solbrå AV et al. Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres. ELIFE. 2016 Aug 5;5. https://doi.org/10.7554/eLife.16940

Bibtex

@article{c8b72954d6d5452183c1268c63183ba1,
title = "Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres",
abstract = "A central tenet of skeletal muscle biology is the existence of an inverse relationship between the oxidative fibre capacity and its size. However, robustness of this relationship is unknown. We show that superimposition of Estrogen-related receptor gamma (Errγ) on the myostatin (Mtn) mouse null background (Mtn(-/-)/Errγ(Tg/+)) results in hypertrophic muscle with a high oxidative capacity thus violating the inverse relationship between fibre size and oxidative capacity. We also examined the canonical view that oxidative muscle phenotype positively correlate with Satellite cell number, the resident stem cells of skeletal muscle. Surprisingly, hypertrophic fibres from Mtn(-/-)/Errγ(Tg/+) mouse showed satellite cell deficit which unexpectedly did not affect muscle regeneration. These observations 1) challenge the concept of a constraint between fibre size and oxidative capacity and 2) indicate the important role of the microcirculation in the regenerative capacity of a muscle even when satellite cell numbers are reduced.",
keywords = "Journal Article",
author = "Saleh Omairi and Antonios Matsakas and Hans Degens and Oliver Kretz and Kenth-Arne Hansson and Solbr{\aa}, {Andreas V{\aa}vang} and Bruusgaard, {Jo C} and Barbara Joch and Roberta Sartori and Natasa Giallourou and Robert Mitchell and Henry Collins-Hooper and Keith Foster and Arja Pasternack and Olli Ritvos and Marco Sandri and Vihang Narkar and Swann, {Jonathan R} and Huber, {Tobias B} and Ketan Patel",
year = "2016",
month = aug,
day = "5",
doi = "10.7554/eLife.16940",
language = "English",
volume = "5",
journal = "ELIFE",
issn = "2050-084X",
publisher = "eLife Sciences Publications",

}

RIS

TY - JOUR

T1 - Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres

AU - Omairi, Saleh

AU - Matsakas, Antonios

AU - Degens, Hans

AU - Kretz, Oliver

AU - Hansson, Kenth-Arne

AU - Solbrå, Andreas Våvang

AU - Bruusgaard, Jo C

AU - Joch, Barbara

AU - Sartori, Roberta

AU - Giallourou, Natasa

AU - Mitchell, Robert

AU - Collins-Hooper, Henry

AU - Foster, Keith

AU - Pasternack, Arja

AU - Ritvos, Olli

AU - Sandri, Marco

AU - Narkar, Vihang

AU - Swann, Jonathan R

AU - Huber, Tobias B

AU - Patel, Ketan

PY - 2016/8/5

Y1 - 2016/8/5

N2 - A central tenet of skeletal muscle biology is the existence of an inverse relationship between the oxidative fibre capacity and its size. However, robustness of this relationship is unknown. We show that superimposition of Estrogen-related receptor gamma (Errγ) on the myostatin (Mtn) mouse null background (Mtn(-/-)/Errγ(Tg/+)) results in hypertrophic muscle with a high oxidative capacity thus violating the inverse relationship between fibre size and oxidative capacity. We also examined the canonical view that oxidative muscle phenotype positively correlate with Satellite cell number, the resident stem cells of skeletal muscle. Surprisingly, hypertrophic fibres from Mtn(-/-)/Errγ(Tg/+) mouse showed satellite cell deficit which unexpectedly did not affect muscle regeneration. These observations 1) challenge the concept of a constraint between fibre size and oxidative capacity and 2) indicate the important role of the microcirculation in the regenerative capacity of a muscle even when satellite cell numbers are reduced.

AB - A central tenet of skeletal muscle biology is the existence of an inverse relationship between the oxidative fibre capacity and its size. However, robustness of this relationship is unknown. We show that superimposition of Estrogen-related receptor gamma (Errγ) on the myostatin (Mtn) mouse null background (Mtn(-/-)/Errγ(Tg/+)) results in hypertrophic muscle with a high oxidative capacity thus violating the inverse relationship between fibre size and oxidative capacity. We also examined the canonical view that oxidative muscle phenotype positively correlate with Satellite cell number, the resident stem cells of skeletal muscle. Surprisingly, hypertrophic fibres from Mtn(-/-)/Errγ(Tg/+) mouse showed satellite cell deficit which unexpectedly did not affect muscle regeneration. These observations 1) challenge the concept of a constraint between fibre size and oxidative capacity and 2) indicate the important role of the microcirculation in the regenerative capacity of a muscle even when satellite cell numbers are reduced.

KW - Journal Article

U2 - 10.7554/eLife.16940

DO - 10.7554/eLife.16940

M3 - SCORING: Journal article

C2 - 27494364

VL - 5

JO - ELIFE

JF - ELIFE

SN - 2050-084X

ER -