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Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts.

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Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts. / Zimmermann, Wolfram-Hubertus; Melnychenko, Ivan; Wasmeier, Gerald; Didié, Michael; Naito, Hiroshi; Nixdorff, Uwe; Hess, Andreas; Budinsky, Lubos; Brune, Kay; Michaelis, Bjela; Dhein, Stefan; Schwoerer, Alexander; Ehmke, Heimo; Eschenhagen, Thomas.

In: NAT MED, Vol. 12, No. 4, 4, 2006, p. 452-458.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zimmermann, W-H, Melnychenko, I, Wasmeier, G, Didié, M, Naito, H, Nixdorff, U, Hess, A, Budinsky, L, Brune, K, Michaelis, B, Dhein, S, Schwoerer, A, Ehmke, H & Eschenhagen, T 2006, 'Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts.', NAT MED, vol. 12, no. 4, 4, pp. 452-458. <http://www.ncbi.nlm.nih.gov/pubmed/16582915?dopt=Citation>

APA

Zimmermann, W-H., Melnychenko, I., Wasmeier, G., Didié, M., Naito, H., Nixdorff, U., Hess, A., Budinsky, L., Brune, K., Michaelis, B., Dhein, S., Schwoerer, A., Ehmke, H., & Eschenhagen, T. (2006). Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts. NAT MED, 12(4), 452-458. [4]. http://www.ncbi.nlm.nih.gov/pubmed/16582915?dopt=Citation

Vancouver

Zimmermann W-H, Melnychenko I, Wasmeier G, Didié M, Naito H, Nixdorff U et al. Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts. NAT MED. 2006;12(4):452-458. 4.

Bibtex

@article{0a95946a50f9407ab07de66f37a58961,
title = "Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts.",
abstract = "The concept of regenerating diseased myocardium by implantation of tissue-engineered heart muscle is intriguing, but convincing evidence is lacking that heart tissues can be generated at a size and with contractile properties that would lend considerable support to failing hearts. Here we created large (thickness/diameter, 1-4 mm/15 mm), force-generating engineered heart tissue from neonatal rat heart cells. Engineered heart tissue formed thick cardiac muscle layers when implanted on myocardial infarcts in immune-suppressed rats. When evaluated 28 d later, engineered heart tissue showed undelayed electrical coupling to the native myocardium without evidence of arrhythmia induction. Moreover, engineered heart tissue prevented further dilation, induced systolic wall thickening of infarcted myocardial segments and improved fractional area shortening of infarcted hearts compared to controls (sham operation and noncontractile constructs). Thus, our study provides evidence that large contractile cardiac tissue grafts can be constructed in vitro, can survive after implantation and can support contractile function of infarcted hearts.",
author = "Wolfram-Hubertus Zimmermann and Ivan Melnychenko and Gerald Wasmeier and Michael Didi{\'e} and Hiroshi Naito and Uwe Nixdorff and Andreas Hess and Lubos Budinsky and Kay Brune and Bjela Michaelis and Stefan Dhein and Alexander Schwoerer and Heimo Ehmke and Thomas Eschenhagen",
year = "2006",
language = "Deutsch",
volume = "12",
pages = "452--458",
journal = "NAT MED",
issn = "1078-8956",
publisher = "NATURE PUBLISHING GROUP",
number = "4",

}

RIS

TY - JOUR

T1 - Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts.

AU - Zimmermann, Wolfram-Hubertus

AU - Melnychenko, Ivan

AU - Wasmeier, Gerald

AU - Didié, Michael

AU - Naito, Hiroshi

AU - Nixdorff, Uwe

AU - Hess, Andreas

AU - Budinsky, Lubos

AU - Brune, Kay

AU - Michaelis, Bjela

AU - Dhein, Stefan

AU - Schwoerer, Alexander

AU - Ehmke, Heimo

AU - Eschenhagen, Thomas

PY - 2006

Y1 - 2006

N2 - The concept of regenerating diseased myocardium by implantation of tissue-engineered heart muscle is intriguing, but convincing evidence is lacking that heart tissues can be generated at a size and with contractile properties that would lend considerable support to failing hearts. Here we created large (thickness/diameter, 1-4 mm/15 mm), force-generating engineered heart tissue from neonatal rat heart cells. Engineered heart tissue formed thick cardiac muscle layers when implanted on myocardial infarcts in immune-suppressed rats. When evaluated 28 d later, engineered heart tissue showed undelayed electrical coupling to the native myocardium without evidence of arrhythmia induction. Moreover, engineered heart tissue prevented further dilation, induced systolic wall thickening of infarcted myocardial segments and improved fractional area shortening of infarcted hearts compared to controls (sham operation and noncontractile constructs). Thus, our study provides evidence that large contractile cardiac tissue grafts can be constructed in vitro, can survive after implantation and can support contractile function of infarcted hearts.

AB - The concept of regenerating diseased myocardium by implantation of tissue-engineered heart muscle is intriguing, but convincing evidence is lacking that heart tissues can be generated at a size and with contractile properties that would lend considerable support to failing hearts. Here we created large (thickness/diameter, 1-4 mm/15 mm), force-generating engineered heart tissue from neonatal rat heart cells. Engineered heart tissue formed thick cardiac muscle layers when implanted on myocardial infarcts in immune-suppressed rats. When evaluated 28 d later, engineered heart tissue showed undelayed electrical coupling to the native myocardium without evidence of arrhythmia induction. Moreover, engineered heart tissue prevented further dilation, induced systolic wall thickening of infarcted myocardial segments and improved fractional area shortening of infarcted hearts compared to controls (sham operation and noncontractile constructs). Thus, our study provides evidence that large contractile cardiac tissue grafts can be constructed in vitro, can survive after implantation and can support contractile function of infarcted hearts.

M3 - SCORING: Zeitschriftenaufsatz

VL - 12

SP - 452

EP - 458

JO - NAT MED

JF - NAT MED

SN - 1078-8956

IS - 4

M1 - 4

ER -