Endovascular treatment of internal carotid artery stenosis: effect of primary stent application on debris particle release in human cadaveric specimens.
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Endovascular treatment of internal carotid artery stenosis: effect of primary stent application on debris particle release in human cadaveric specimens. / Wittkugel, Oliver; Fiehler, Jens; Koch, Christoph; Eckert, Bernd; Kilic, Ergin; Frahm, Mathias; Zeumer, Hermann.
In: RADIOLOGY, Vol. 229, No. 3, 3, 2003, p. 855-860.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Endovascular treatment of internal carotid artery stenosis: effect of primary stent application on debris particle release in human cadaveric specimens.
AU - Wittkugel, Oliver
AU - Fiehler, Jens
AU - Koch, Christoph
AU - Eckert, Bernd
AU - Kilic, Ergin
AU - Frahm, Mathias
AU - Zeumer, Hermann
PY - 2003
Y1 - 2003
N2 - PURPOSE: To compare debris release with primary stent application (self-expanding stent application at stenosis and then balloon dilation through the opened stent) and that with secondary stent application (balloon angioplasty of stenosis and afterward additional stent application) for high-grade internal carotid artery stenosis in human cadaveric specimens. MATERIALS AND METHODS: Fresh human cadaveric internal carotid artery specimens were attached to a tube system. High-grade stenoses (>66%) were selected, randomized for primary or secondary stent application, and then treated, with fluoroscopic guidance, while the system was rinsed in a pulsating flow. Fluid was collected and filtered, and debris particles were examined with a light microscope. Particles were analyzed according to those consecutively caught by 100 x 100-microm and 11 x 11-microm mesh filters. Results were evaluated in relation to stent application. For statistical analyses of group differences, the exact Mann-Whitney U test was used. RESULTS: Thirteen high-grade human cadaveric internal carotid artery stenoses were analyzed. Five specimens were randomly assigned to secondary stent application, and eight were assigned to primary stent application. No significant difference could be demonstrated for debris release with primary or secondary stent application. P values ranged from.051 to.754. CONCLUSION: The reported superiority of primary stent application may not be related to debris reduction.
AB - PURPOSE: To compare debris release with primary stent application (self-expanding stent application at stenosis and then balloon dilation through the opened stent) and that with secondary stent application (balloon angioplasty of stenosis and afterward additional stent application) for high-grade internal carotid artery stenosis in human cadaveric specimens. MATERIALS AND METHODS: Fresh human cadaveric internal carotid artery specimens were attached to a tube system. High-grade stenoses (>66%) were selected, randomized for primary or secondary stent application, and then treated, with fluoroscopic guidance, while the system was rinsed in a pulsating flow. Fluid was collected and filtered, and debris particles were examined with a light microscope. Particles were analyzed according to those consecutively caught by 100 x 100-microm and 11 x 11-microm mesh filters. Results were evaluated in relation to stent application. For statistical analyses of group differences, the exact Mann-Whitney U test was used. RESULTS: Thirteen high-grade human cadaveric internal carotid artery stenoses were analyzed. Five specimens were randomly assigned to secondary stent application, and eight were assigned to primary stent application. No significant difference could be demonstrated for debris release with primary or secondary stent application. P values ranged from.051 to.754. CONCLUSION: The reported superiority of primary stent application may not be related to debris reduction.
M3 - SCORING: Zeitschriftenaufsatz
VL - 229
SP - 855
EP - 860
JO - RADIOLOGY
JF - RADIOLOGY
SN - 0033-8419
IS - 3
M1 - 3
ER -
