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Endoscopic lung volume reduction coil treatment in patients with very low FEV: an observational study

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Endoscopic lung volume reduction coil treatment in patients with very low FEV: an observational study. / Simon, Marcel; Harbaum, Lars; Oqueka, Tim; Kluge, Stefan; Klose, Hans.

In: THER ADV RESPIR DIS, Vol. 12, 27.02.2018, p. 1-10.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Simon, M, Harbaum, L, Oqueka, T, Kluge, S & Klose, H 2018, 'Endoscopic lung volume reduction coil treatment in patients with very low FEV: an observational study', THER ADV RESPIR DIS, vol. 12, pp. 1-10. https://doi.org/10.1177/1753466618760133

APA

Simon, M., Harbaum, L., Oqueka, T., Kluge, S., & Klose, H. (2018). Endoscopic lung volume reduction coil treatment in patients with very low FEV: an observational study. THER ADV RESPIR DIS, 12, 1-10. https://doi.org/10.1177/1753466618760133

Vancouver

Simon M, Harbaum L, Oqueka T, Kluge S, Klose H. Endoscopic lung volume reduction coil treatment in patients with very low FEV: an observational study. THER ADV RESPIR DIS. 2018 Feb 27;12:1-10. https://doi.org/10.1177/1753466618760133

Bibtex

@article{866a245b847a4d75bb3f12c9ff23e30d,
title = "Endoscopic lung volume reduction coil treatment in patients with very low FEV: an observational study",
abstract = "BACKGROUND: Endoscopic lung volume reduction coil (LVRC) treatment is a therapeutic option for selected patients with advanced emphysema. The effects and the safety of endoscopic lung volume reduction in patients with very low forced expired volume in one second (FEV1) remain to be determined. This study was conducted to assess the effects and the safety of LVRC treatment in patients with very low FEV1.METHODS: The study was performed as a retrospective observational study in the Department of Respiratory Medicine at the University Medical Center Hamburg-Eppendorf on patients with very low FEV1, defined as an FEV1⩽ 20% of predicted at baseline in whom LVRC treatment was performed between 1 April 2012 and 28 February 2017.RESULTS: LVRC treatment was performed in 33 patients with very low FEV1. Of these, 45.5% were female and 54.5% were male. At baseline, mean FEV1was 0.46 ± 0.12 liters (15 ± 3% of predicted), mean forced vital capacity (FVC) was 1.61 ± 0.62 liters (42 ± 13% of predicted), mean residual volume (RV) was 6.03 ± 0.81 liters (275 ± 51% of predicted) and 6-minute walk distance was 229 ± 102 m. Bilateral LVRC treatment was completed in 21 of these patients (63.6%). Bilateral LVRC treatment led to significant improvements in functional parameters with an increase in mean FEV1from 0.44 ± 0.11 liters to 0.54 ± 0.12 liters ( p = 0.001), equivalent to a relative improvement of 24.5 ± 26.9%, an increase in mean FVC from 1.49 ± 0.54 liters to 1.84 ± 0.49 liters ( p = 0.001), a decrease in mean RV from 6.27 ± 0.83 liters to 5.83 ± 1.09 liters ( p = 0.004) and an improvement in 6-minute walk distance from 218 ± 91 m to 266 ± 96 m ( p = 0.01). There were no cases of respiratory failure requiring mechanical ventilation and no deaths.CONCLUSIONS: LVRC treatment was effective and safe in patients with very low FEV1.",
keywords = "Journal Article",
author = "Marcel Simon and Lars Harbaum and Tim Oqueka and Stefan Kluge and Hans Klose",
year = "2018",
month = feb,
day = "27",
doi = "10.1177/1753466618760133",
language = "English",
volume = "12",
pages = "1--10",
journal = "THER ADV RESPIR DIS",
issn = "1753-4658",
publisher = "SAGE Publications",

}

RIS

TY - JOUR

T1 - Endoscopic lung volume reduction coil treatment in patients with very low FEV: an observational study

AU - Simon, Marcel

AU - Harbaum, Lars

AU - Oqueka, Tim

AU - Kluge, Stefan

AU - Klose, Hans

PY - 2018/2/27

Y1 - 2018/2/27

N2 - BACKGROUND: Endoscopic lung volume reduction coil (LVRC) treatment is a therapeutic option for selected patients with advanced emphysema. The effects and the safety of endoscopic lung volume reduction in patients with very low forced expired volume in one second (FEV1) remain to be determined. This study was conducted to assess the effects and the safety of LVRC treatment in patients with very low FEV1.METHODS: The study was performed as a retrospective observational study in the Department of Respiratory Medicine at the University Medical Center Hamburg-Eppendorf on patients with very low FEV1, defined as an FEV1⩽ 20% of predicted at baseline in whom LVRC treatment was performed between 1 April 2012 and 28 February 2017.RESULTS: LVRC treatment was performed in 33 patients with very low FEV1. Of these, 45.5% were female and 54.5% were male. At baseline, mean FEV1was 0.46 ± 0.12 liters (15 ± 3% of predicted), mean forced vital capacity (FVC) was 1.61 ± 0.62 liters (42 ± 13% of predicted), mean residual volume (RV) was 6.03 ± 0.81 liters (275 ± 51% of predicted) and 6-minute walk distance was 229 ± 102 m. Bilateral LVRC treatment was completed in 21 of these patients (63.6%). Bilateral LVRC treatment led to significant improvements in functional parameters with an increase in mean FEV1from 0.44 ± 0.11 liters to 0.54 ± 0.12 liters ( p = 0.001), equivalent to a relative improvement of 24.5 ± 26.9%, an increase in mean FVC from 1.49 ± 0.54 liters to 1.84 ± 0.49 liters ( p = 0.001), a decrease in mean RV from 6.27 ± 0.83 liters to 5.83 ± 1.09 liters ( p = 0.004) and an improvement in 6-minute walk distance from 218 ± 91 m to 266 ± 96 m ( p = 0.01). There were no cases of respiratory failure requiring mechanical ventilation and no deaths.CONCLUSIONS: LVRC treatment was effective and safe in patients with very low FEV1.

AB - BACKGROUND: Endoscopic lung volume reduction coil (LVRC) treatment is a therapeutic option for selected patients with advanced emphysema. The effects and the safety of endoscopic lung volume reduction in patients with very low forced expired volume in one second (FEV1) remain to be determined. This study was conducted to assess the effects and the safety of LVRC treatment in patients with very low FEV1.METHODS: The study was performed as a retrospective observational study in the Department of Respiratory Medicine at the University Medical Center Hamburg-Eppendorf on patients with very low FEV1, defined as an FEV1⩽ 20% of predicted at baseline in whom LVRC treatment was performed between 1 April 2012 and 28 February 2017.RESULTS: LVRC treatment was performed in 33 patients with very low FEV1. Of these, 45.5% were female and 54.5% were male. At baseline, mean FEV1was 0.46 ± 0.12 liters (15 ± 3% of predicted), mean forced vital capacity (FVC) was 1.61 ± 0.62 liters (42 ± 13% of predicted), mean residual volume (RV) was 6.03 ± 0.81 liters (275 ± 51% of predicted) and 6-minute walk distance was 229 ± 102 m. Bilateral LVRC treatment was completed in 21 of these patients (63.6%). Bilateral LVRC treatment led to significant improvements in functional parameters with an increase in mean FEV1from 0.44 ± 0.11 liters to 0.54 ± 0.12 liters ( p = 0.001), equivalent to a relative improvement of 24.5 ± 26.9%, an increase in mean FVC from 1.49 ± 0.54 liters to 1.84 ± 0.49 liters ( p = 0.001), a decrease in mean RV from 6.27 ± 0.83 liters to 5.83 ± 1.09 liters ( p = 0.004) and an improvement in 6-minute walk distance from 218 ± 91 m to 266 ± 96 m ( p = 0.01). There were no cases of respiratory failure requiring mechanical ventilation and no deaths.CONCLUSIONS: LVRC treatment was effective and safe in patients with very low FEV1.

KW - Journal Article

U2 - 10.1177/1753466618760133

DO - 10.1177/1753466618760133

M3 - SCORING: Journal article

C2 - 29480070

VL - 12

SP - 1

EP - 10

JO - THER ADV RESPIR DIS

JF - THER ADV RESPIR DIS

SN - 1753-4658

ER -