Emotional valence and semantic relatedness differentially influence false recognition in mild cognitive impairment, Alzheimer's disease, and healthy elderly.
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Emotional valence and semantic relatedness differentially influence false recognition in mild cognitive impairment, Alzheimer's disease, and healthy elderly. / Brueckner, Katja; Moritz, Steffen.
In: J INT NEUROPSYCH SOC, Vol. 15, No. 2, 2, 2009, p. 268-276.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Emotional valence and semantic relatedness differentially influence false recognition in mild cognitive impairment, Alzheimer's disease, and healthy elderly.
AU - Brueckner, Katja
AU - Moritz, Steffen
PY - 2009
Y1 - 2009
N2 - This study examined whether patients with mild cognitive impairment (MCI) who are at higher risk for later Alzheimer disease (AD) display deficits comparable to patients with diagnosed dementia. We assessed 27 patients with MCI, 36 patients with AD, and 20 healthy older adults with an emotional variant of the Deese-Roediger-McDermott-paradigm. Participants studied four lists that were semantically related to a nonpresented critical theme word. These theme words were either depression-related (i.e., loneliness) or delusion-related (betrayal) or had a positive (holidays) or neutral (window) valence. Despite a normal overall emotional memory and a normal corrected overall false recognition, patients with MCI, as predicted, produced as many false memories as patients with AD. On closer examination, both patient groups showed enhanced false memories to unrelated stimuli and a significant bias to falsely remember stimuli with a positive valence. We conclude that although patients with MCI are not distinguishable from healthy older adults in terms of their overall emotional recognition, positively valenced memories and more specifically false positive memories may represent the signature of a breakdown of emotional memory along the continuum between normal aging and AD.
AB - This study examined whether patients with mild cognitive impairment (MCI) who are at higher risk for later Alzheimer disease (AD) display deficits comparable to patients with diagnosed dementia. We assessed 27 patients with MCI, 36 patients with AD, and 20 healthy older adults with an emotional variant of the Deese-Roediger-McDermott-paradigm. Participants studied four lists that were semantically related to a nonpresented critical theme word. These theme words were either depression-related (i.e., loneliness) or delusion-related (betrayal) or had a positive (holidays) or neutral (window) valence. Despite a normal overall emotional memory and a normal corrected overall false recognition, patients with MCI, as predicted, produced as many false memories as patients with AD. On closer examination, both patient groups showed enhanced false memories to unrelated stimuli and a significant bias to falsely remember stimuli with a positive valence. We conclude that although patients with MCI are not distinguishable from healthy older adults in terms of their overall emotional recognition, positively valenced memories and more specifically false positive memories may represent the signature of a breakdown of emotional memory along the continuum between normal aging and AD.
M3 - SCORING: Zeitschriftenaufsatz
VL - 15
SP - 268
EP - 276
JO - J INT NEUROPSYCH SOC
JF - J INT NEUROPSYCH SOC
SN - 1355-6177
IS - 2
M1 - 2
ER -
