Emerging roles of NAD+ and its metabolites in cell signaling.
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Emerging roles of NAD+ and its metabolites in cell signaling. / Koch Nolte, Friedrich; Haag, Friedrich; Guse, Andreas H.; Lund, Frances; Ziegler, Mathias.
In: SCI SIGNAL, Vol. 2, No. 57, 57, 2009, p. 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Emerging roles of NAD+ and its metabolites in cell signaling.
AU - Koch Nolte, Friedrich
AU - Haag, Friedrich
AU - Guse, Andreas H.
AU - Lund, Frances
AU - Ziegler, Mathias
PY - 2009
Y1 - 2009
N2 - Nicotinamide adenine dinucleotide (NAD(+)) is the universal currency of energy metabolism and electron transfer. Recent studies indicate that apart from its role as a coenzyme, NAD(+) and its metabolites also function in cell signaling pathways; for example, they are substrates for nucleotide-metabolizing enzymes and ligands for extra- and intracellular receptors and ion channels. Moreover, the NAD(+) and NAD(+) phosphate metabolites adenosine 5'-diphosphoribose (ADP-ribose), cyclic ADP-ribose, and nicotinic acid adenine dinucleotide phosphate (NAADP) have emerged as key second messengers in Ca(2+) signaling. A symposium in Hamburg, Germany, brought together 120 researchers from various fields, who were all engaged in the molecular characterization of the key players of NAD(+) signaling (www.NAD2008.de).
AB - Nicotinamide adenine dinucleotide (NAD(+)) is the universal currency of energy metabolism and electron transfer. Recent studies indicate that apart from its role as a coenzyme, NAD(+) and its metabolites also function in cell signaling pathways; for example, they are substrates for nucleotide-metabolizing enzymes and ligands for extra- and intracellular receptors and ion channels. Moreover, the NAD(+) and NAD(+) phosphate metabolites adenosine 5'-diphosphoribose (ADP-ribose), cyclic ADP-ribose, and nicotinic acid adenine dinucleotide phosphate (NAADP) have emerged as key second messengers in Ca(2+) signaling. A symposium in Hamburg, Germany, brought together 120 researchers from various fields, who were all engaged in the molecular characterization of the key players of NAD(+) signaling (www.NAD2008.de).
M3 - SCORING: Zeitschriftenaufsatz
VL - 2
SP - 1
JO - SCI SIGNAL
JF - SCI SIGNAL
SN - 1945-0877
IS - 57
M1 - 57
ER -
