Elevated tissue expression of hyaluronic acid and hyaluronidase validates the HA-HAase urine test for bladder cancer.
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Elevated tissue expression of hyaluronic acid and hyaluronidase validates the HA-HAase urine test for bladder cancer. / Hautmann, S H; Lokeshwar, V B; Schroeder, G L; Civantos, F; Duncan, R C; Gnann, R; Friedrich, Martin; Soloway, M S.
In: J UROLOGY, Vol. 165(6 Pt 1), 2001, p. 2068-2074.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Elevated tissue expression of hyaluronic acid and hyaluronidase validates the HA-HAase urine test for bladder cancer.
AU - Hautmann, S H
AU - Lokeshwar, V B
AU - Schroeder, G L
AU - Civantos, F
AU - Duncan, R C
AU - Gnann, R
AU - Friedrich, Martin
AU - Soloway, M S
PY - 2001
Y1 - 2001
N2 - PURPOSE: We examined the expression of 2 bladder tumor markers, hyaluronic acid (HA) and hyaluronidase (HAase), in bladder tissues and correlated tissue staining with the inferences of the HA-HAase urine test, which detects bladder cancer. MATERIALS AND METHODS: A biotinylated HA binding protein and an antiHYAL1 antibody were used to localize HA and HYAL1 type HAase, respectively, in 83 bladder tissues. Immunoblot analysis was performed using an antiHYAL1 antibody to detect HYAL1. RESULTS: A total of 12 normal bladder tissues showed no (66%) to 1+ (34%) HA staining and 0 (83%) to 1+ (17%) HYAL1 staining. The staining intensity of HA and HYAL1 increased in 71 bladder tumor specimens on chi-square analysis (p
AB - PURPOSE: We examined the expression of 2 bladder tumor markers, hyaluronic acid (HA) and hyaluronidase (HAase), in bladder tissues and correlated tissue staining with the inferences of the HA-HAase urine test, which detects bladder cancer. MATERIALS AND METHODS: A biotinylated HA binding protein and an antiHYAL1 antibody were used to localize HA and HYAL1 type HAase, respectively, in 83 bladder tissues. Immunoblot analysis was performed using an antiHYAL1 antibody to detect HYAL1. RESULTS: A total of 12 normal bladder tissues showed no (66%) to 1+ (34%) HA staining and 0 (83%) to 1+ (17%) HYAL1 staining. The staining intensity of HA and HYAL1 increased in 71 bladder tumor specimens on chi-square analysis (p
M3 - SCORING: Zeitschriftenaufsatz
VL - 165(6 Pt 1)
SP - 2068
EP - 2074
JO - J UROLOGY
JF - J UROLOGY
SN - 0022-5347
ER -