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Electrocardiographic scores of severity and acuteness of myocardial ischemia predict myocardial salvage in patients with anterior ST-segment elevation myocardial infarction

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Electrocardiographic scores of severity and acuteness of myocardial ischemia predict myocardial salvage in patients with anterior ST-segment elevation myocardial infarction. / Fakhri, Yama; Sejersten, Maria; Schoos, Mikkel Malby; Hansen, Henrik Steen; Dubois-Rande, Jean-Luc; Hall, Trygve S; Larsen, Alf-Inge; Jensen, Svend Eggert; Engblom, Henrik; Arheden, Hakon; Kastrup, Jens; Atar, Dan; Clemmensen, Peter.

In: J ELECTROCARDIOL, Vol. 51, No. 2, 28.11.2017, p. 195-202.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fakhri, Y, Sejersten, M, Schoos, MM, Hansen, HS, Dubois-Rande, J-L, Hall, TS, Larsen, A-I, Jensen, SE, Engblom, H, Arheden, H, Kastrup, J, Atar, D & Clemmensen, P 2017, 'Electrocardiographic scores of severity and acuteness of myocardial ischemia predict myocardial salvage in patients with anterior ST-segment elevation myocardial infarction', J ELECTROCARDIOL, vol. 51, no. 2, pp. 195-202. https://doi.org/10.1016/j.jelectrocard.2017.11.002

APA

Fakhri, Y., Sejersten, M., Schoos, M. M., Hansen, H. S., Dubois-Rande, J-L., Hall, T. S., Larsen, A-I., Jensen, S. E., Engblom, H., Arheden, H., Kastrup, J., Atar, D., & Clemmensen, P. (2017). Electrocardiographic scores of severity and acuteness of myocardial ischemia predict myocardial salvage in patients with anterior ST-segment elevation myocardial infarction. J ELECTROCARDIOL, 51(2), 195-202. https://doi.org/10.1016/j.jelectrocard.2017.11.002

Vancouver

Fakhri Y, Sejersten M, Schoos MM, Hansen HS, Dubois-Rande J-L, Hall TS et al. Electrocardiographic scores of severity and acuteness of myocardial ischemia predict myocardial salvage in patients with anterior ST-segment elevation myocardial infarction. J ELECTROCARDIOL. 2017 Nov 28;51(2):195-202. https://doi.org/10.1016/j.jelectrocard.2017.11.002

Bibtex

@article{e7826336a5484e99a5f3c7342860f559,
title = "Electrocardiographic scores of severity and acuteness of myocardial ischemia predict myocardial salvage in patients with anterior ST-segment elevation myocardial infarction",
abstract = "BACKGROUND: Terminal {"}QRS distortion{"} on the electrocardiogram (ECG) (based on Sclarovsky-Birnbaum's Grades of Ischemia Score) is a sign of severe ischemia, associated with adverse cardiovascular outcome in ST-segment elevation myocardial infarction (STEMI). In addition, ECG indices of the acuteness of ischemia (based on Anderson-Wilkins Acuteness Score) indicate myocardial salvage potential. We assessed whether severe ischemia with or without acute ischemia is predictive of infarct size (IS), myocardial salvage index (MSI) and left ventricular ejection fraction (LVEF) in anterior versus inferior infarct locations.METHODS: In STEMI patients, the severity and acuteness scores were obtained from the admission ECG. Based on the ECG patients were assigned with severe or non-severe ischemia and acute or non-acute ischemia. Cardiac magnetic resonance (CMR) was performed 2-6days after primary percutaneous coronary intervention (pPCI). LVEF was measured by echocardiography 30days after pPCI.RESULTS: ECG analysis of 85 patients with available CMR resulted in 20 (23%) cases with severe and non-acute ischemia, 43 (51%) with non-severe and non-acute ischemia, 17 (20%) with non-severe and acute ischemia, and 5 (6%) patients with severe and acute ischemia. In patients with anterior STEMI (n=35), ECG measures of severity and acuteness of ischemia identified significant and stepwise differences in myocardial damage and function. Patients with severe and non-acute ischemia had the largest IS, smallest MSI and lowest LVEF. In contrast, no difference was observed in patients with inferior STEMI (n=50).CONCLUSIONS: The applicability of ECG indices of severity and acuteness of myocardial ischemia to estimate myocardial damage and salvage potential in STEMI patients treated with pPCI, is confined to anterior myocardial infarction.",
keywords = "Double-Blind Method, Electrocardiography, Female, Humans, Magnetic Resonance Imaging, Male, Myocardial Ischemia/diagnostic imaging, Percutaneous Coronary Intervention, Prospective Studies, ST Elevation Myocardial Infarction/diagnostic imaging, Severity of Illness Index, Treatment Outcome",
author = "Yama Fakhri and Maria Sejersten and Schoos, {Mikkel Malby} and Hansen, {Henrik Steen} and Jean-Luc Dubois-Rande and Hall, {Trygve S} and Alf-Inge Larsen and Jensen, {Svend Eggert} and Henrik Engblom and Hakon Arheden and Jens Kastrup and Dan Atar and Peter Clemmensen",
note = "Copyright {\textcopyright} 2017 Elsevier Inc. All rights reserved.",
year = "2017",
month = nov,
day = "28",
doi = "10.1016/j.jelectrocard.2017.11.002",
language = "English",
volume = "51",
pages = "195--202",
journal = "J ELECTROCARDIOL",
issn = "0022-0736",
publisher = "Churchill Livingstone",
number = "2",

}

RIS

TY - JOUR

T1 - Electrocardiographic scores of severity and acuteness of myocardial ischemia predict myocardial salvage in patients with anterior ST-segment elevation myocardial infarction

AU - Fakhri, Yama

AU - Sejersten, Maria

AU - Schoos, Mikkel Malby

AU - Hansen, Henrik Steen

AU - Dubois-Rande, Jean-Luc

AU - Hall, Trygve S

AU - Larsen, Alf-Inge

AU - Jensen, Svend Eggert

AU - Engblom, Henrik

AU - Arheden, Hakon

AU - Kastrup, Jens

AU - Atar, Dan

AU - Clemmensen, Peter

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2017/11/28

Y1 - 2017/11/28

N2 - BACKGROUND: Terminal "QRS distortion" on the electrocardiogram (ECG) (based on Sclarovsky-Birnbaum's Grades of Ischemia Score) is a sign of severe ischemia, associated with adverse cardiovascular outcome in ST-segment elevation myocardial infarction (STEMI). In addition, ECG indices of the acuteness of ischemia (based on Anderson-Wilkins Acuteness Score) indicate myocardial salvage potential. We assessed whether severe ischemia with or without acute ischemia is predictive of infarct size (IS), myocardial salvage index (MSI) and left ventricular ejection fraction (LVEF) in anterior versus inferior infarct locations.METHODS: In STEMI patients, the severity and acuteness scores were obtained from the admission ECG. Based on the ECG patients were assigned with severe or non-severe ischemia and acute or non-acute ischemia. Cardiac magnetic resonance (CMR) was performed 2-6days after primary percutaneous coronary intervention (pPCI). LVEF was measured by echocardiography 30days after pPCI.RESULTS: ECG analysis of 85 patients with available CMR resulted in 20 (23%) cases with severe and non-acute ischemia, 43 (51%) with non-severe and non-acute ischemia, 17 (20%) with non-severe and acute ischemia, and 5 (6%) patients with severe and acute ischemia. In patients with anterior STEMI (n=35), ECG measures of severity and acuteness of ischemia identified significant and stepwise differences in myocardial damage and function. Patients with severe and non-acute ischemia had the largest IS, smallest MSI and lowest LVEF. In contrast, no difference was observed in patients with inferior STEMI (n=50).CONCLUSIONS: The applicability of ECG indices of severity and acuteness of myocardial ischemia to estimate myocardial damage and salvage potential in STEMI patients treated with pPCI, is confined to anterior myocardial infarction.

AB - BACKGROUND: Terminal "QRS distortion" on the electrocardiogram (ECG) (based on Sclarovsky-Birnbaum's Grades of Ischemia Score) is a sign of severe ischemia, associated with adverse cardiovascular outcome in ST-segment elevation myocardial infarction (STEMI). In addition, ECG indices of the acuteness of ischemia (based on Anderson-Wilkins Acuteness Score) indicate myocardial salvage potential. We assessed whether severe ischemia with or without acute ischemia is predictive of infarct size (IS), myocardial salvage index (MSI) and left ventricular ejection fraction (LVEF) in anterior versus inferior infarct locations.METHODS: In STEMI patients, the severity and acuteness scores were obtained from the admission ECG. Based on the ECG patients were assigned with severe or non-severe ischemia and acute or non-acute ischemia. Cardiac magnetic resonance (CMR) was performed 2-6days after primary percutaneous coronary intervention (pPCI). LVEF was measured by echocardiography 30days after pPCI.RESULTS: ECG analysis of 85 patients with available CMR resulted in 20 (23%) cases with severe and non-acute ischemia, 43 (51%) with non-severe and non-acute ischemia, 17 (20%) with non-severe and acute ischemia, and 5 (6%) patients with severe and acute ischemia. In patients with anterior STEMI (n=35), ECG measures of severity and acuteness of ischemia identified significant and stepwise differences in myocardial damage and function. Patients with severe and non-acute ischemia had the largest IS, smallest MSI and lowest LVEF. In contrast, no difference was observed in patients with inferior STEMI (n=50).CONCLUSIONS: The applicability of ECG indices of severity and acuteness of myocardial ischemia to estimate myocardial damage and salvage potential in STEMI patients treated with pPCI, is confined to anterior myocardial infarction.

KW - Double-Blind Method

KW - Electrocardiography

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Myocardial Ischemia/diagnostic imaging

KW - Percutaneous Coronary Intervention

KW - Prospective Studies

KW - ST Elevation Myocardial Infarction/diagnostic imaging

KW - Severity of Illness Index

KW - Treatment Outcome

U2 - 10.1016/j.jelectrocard.2017.11.002

DO - 10.1016/j.jelectrocard.2017.11.002

M3 - SCORING: Journal article

C2 - 29174706

VL - 51

SP - 195

EP - 202

JO - J ELECTROCARDIOL

JF - J ELECTROCARDIOL

SN - 0022-0736

IS - 2

ER -