Research ExplorerPublicationsElderly patients diagnosed with idiopathic pulmonary arteria...

Elderly patients diagnosed with idiopathic pulmonary arterial hypertension

Standard

Elderly patients diagnosed with idiopathic pulmonary arterial hypertension : results from the COMPERA registry. / Hoeper, Marius M; Huscher, Doerte; Ghofrani, H Ardeschir; Delcroix, Marion; Distler, Oliver; Schweiger, Christian; Grunig, Ekkehard; Staehler, Gerd; Rosenkranz, Stephan; Halank, Michael; Held, Matthias; Grohé, Christian; Lange, Tobias J; Behr, Juergen; Klose, Hans; Wilkens, Heinrike; Filusch, Arthur; Germann, Martin; Ewert, Ralf; Seyfarth, Hans-Juergen; Olsson, Karen M; Opitz, Christian F; Gaine, Sean P; Vizza, C Dario; Vonk-Noordegraaf, Anton; Kaemmerer, Harald; Gibbs, J Simon R; Pittrow, David.

In: INT J CARDIOL, Vol. 168, No. 2, 30.09.2013, p. 871-80.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hoeper, MM, Huscher, D, Ghofrani, HA, Delcroix, M, Distler, O, Schweiger, C, Grunig, E, Staehler, G, Rosenkranz, S, Halank, M, Held, M, Grohé, C, Lange, TJ, Behr, J, Klose, H, Wilkens, H, Filusch, A, Germann, M, Ewert, R, Seyfarth, H-J, Olsson, KM, Opitz, CF, Gaine, SP, Vizza, CD, Vonk-Noordegraaf, A, Kaemmerer, H, Gibbs, JSR & Pittrow, D 2013, 'Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: results from the COMPERA registry', INT J CARDIOL, vol. 168, no. 2, pp. 871-80. https://doi.org/10.1016/j.ijcard.2012.10.026

APA

Hoeper, M. M., Huscher, D., Ghofrani, H. A., Delcroix, M., Distler, O., Schweiger, C., Grunig, E., Staehler, G., Rosenkranz, S., Halank, M., Held, M., Grohé, C., Lange, T. J., Behr, J., Klose, H., Wilkens, H., Filusch, A., Germann, M., Ewert, R., ... Pittrow, D. (2013). Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: results from the COMPERA registry. INT J CARDIOL, 168(2), 871-80. https://doi.org/10.1016/j.ijcard.2012.10.026

Vancouver

Hoeper MM, Huscher D, Ghofrani HA, Delcroix M, Distler O, Schweiger C et al. Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: results from the COMPERA registry. INT J CARDIOL. 2013 Sep 30;168(2):871-80. https://doi.org/10.1016/j.ijcard.2012.10.026

Bibtex

@article{698bee69aa3f4dedbc2ec4bb9b88f8a7,
title = "Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: results from the COMPERA registry",
abstract = "BACKGROUND: Originally reported to occur predominantly in younger women, idiopathic pulmonary arterial hypertension (IPAH) is increasingly diagnosed in elderly patients. We aimed to describe the characteristics of such patients and their survival under clinical practice conditions.METHODS: Prospective registry in 28 centers in 6 European countries. Demographics, clinical characteristics, hemodynamics, treatment patterns and outcomes of younger (18-65 years) and elderly (>65 years) patients with newly diagnosed IPAH (incident cases only) were compared.RESULTS: A total of 587 patients were eligible for analysis. The median (interquartile, [IQR]) age at diagnosis was 71 (16) years. Younger patients (n=209; median age, 54 [16] years) showed a female-to-male ratio of 2.3:1 whereas the gender ratio in elderly patients (n=378; median age, 75 [8] years) was almost even (1.2:1). Combinations of PAH drugs were widely used in both populations, albeit less frequently in older patients. Elderly patients were less likely to reach current treatment targets (6 min walking distance>400 m, functional class I or II). The survival rates 1, 2, and 3 years after the diagnosis of IPAH were lower in elderly patients, even when adjusted for age- and gender-matched survival tables of the general population (p=0.006 by log-rank analysis).CONCLUSIONS: In countries with an aging population, IPAH is now frequently diagnosed in elderly patients. Compared to younger patients, elderly patients present with a balanced gender ratio and different clinical features, respond less well to medical therapy and have a higher age-adjusted mortality. Further characterization of these patients is required. Clinical trials registration: NCT01347216.",
keywords = "Adult, Aged, Aged, 80 and over, Female, Humans, Hypertension, Pulmonary, Male, Middle Aged, Prospective Studies, Registries, Survival Rate",
author = "Hoeper, {Marius M} and Doerte Huscher and Ghofrani, {H Ardeschir} and Marion Delcroix and Oliver Distler and Christian Schweiger and Ekkehard Grunig and Gerd Staehler and Stephan Rosenkranz and Michael Halank and Matthias Held and Christian Groh{\'e} and Lange, {Tobias J} and Juergen Behr and Hans Klose and Heinrike Wilkens and Arthur Filusch and Martin Germann and Ralf Ewert and Hans-Juergen Seyfarth and Olsson, {Karen M} and Opitz, {Christian F} and Gaine, {Sean P} and Vizza, {C Dario} and Anton Vonk-Noordegraaf and Harald Kaemmerer and Gibbs, {J Simon R} and David Pittrow",
note = "Copyright {\textcopyright} 2012 Elsevier Ireland Ltd. All rights reserved.",
year = "2013",
month = sep,
day = "30",
doi = "10.1016/j.ijcard.2012.10.026",
language = "English",
volume = "168",
pages = "871--80",
journal = "INT J CARDIOL",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Elderly patients diagnosed with idiopathic pulmonary arterial hypertension

T2 - results from the COMPERA registry

AU - Hoeper, Marius M

AU - Huscher, Doerte

AU - Ghofrani, H Ardeschir

AU - Delcroix, Marion

AU - Distler, Oliver

AU - Schweiger, Christian

AU - Grunig, Ekkehard

AU - Staehler, Gerd

AU - Rosenkranz, Stephan

AU - Halank, Michael

AU - Held, Matthias

AU - Grohé, Christian

AU - Lange, Tobias J

AU - Behr, Juergen

AU - Klose, Hans

AU - Wilkens, Heinrike

AU - Filusch, Arthur

AU - Germann, Martin

AU - Ewert, Ralf

AU - Seyfarth, Hans-Juergen

AU - Olsson, Karen M

AU - Opitz, Christian F

AU - Gaine, Sean P

AU - Vizza, C Dario

AU - Vonk-Noordegraaf, Anton

AU - Kaemmerer, Harald

AU - Gibbs, J Simon R

AU - Pittrow, David

N1 - Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

PY - 2013/9/30

Y1 - 2013/9/30

N2 - BACKGROUND: Originally reported to occur predominantly in younger women, idiopathic pulmonary arterial hypertension (IPAH) is increasingly diagnosed in elderly patients. We aimed to describe the characteristics of such patients and their survival under clinical practice conditions.METHODS: Prospective registry in 28 centers in 6 European countries. Demographics, clinical characteristics, hemodynamics, treatment patterns and outcomes of younger (18-65 years) and elderly (>65 years) patients with newly diagnosed IPAH (incident cases only) were compared.RESULTS: A total of 587 patients were eligible for analysis. The median (interquartile, [IQR]) age at diagnosis was 71 (16) years. Younger patients (n=209; median age, 54 [16] years) showed a female-to-male ratio of 2.3:1 whereas the gender ratio in elderly patients (n=378; median age, 75 [8] years) was almost even (1.2:1). Combinations of PAH drugs were widely used in both populations, albeit less frequently in older patients. Elderly patients were less likely to reach current treatment targets (6 min walking distance>400 m, functional class I or II). The survival rates 1, 2, and 3 years after the diagnosis of IPAH were lower in elderly patients, even when adjusted for age- and gender-matched survival tables of the general population (p=0.006 by log-rank analysis).CONCLUSIONS: In countries with an aging population, IPAH is now frequently diagnosed in elderly patients. Compared to younger patients, elderly patients present with a balanced gender ratio and different clinical features, respond less well to medical therapy and have a higher age-adjusted mortality. Further characterization of these patients is required. Clinical trials registration: NCT01347216.

AB - BACKGROUND: Originally reported to occur predominantly in younger women, idiopathic pulmonary arterial hypertension (IPAH) is increasingly diagnosed in elderly patients. We aimed to describe the characteristics of such patients and their survival under clinical practice conditions.METHODS: Prospective registry in 28 centers in 6 European countries. Demographics, clinical characteristics, hemodynamics, treatment patterns and outcomes of younger (18-65 years) and elderly (>65 years) patients with newly diagnosed IPAH (incident cases only) were compared.RESULTS: A total of 587 patients were eligible for analysis. The median (interquartile, [IQR]) age at diagnosis was 71 (16) years. Younger patients (n=209; median age, 54 [16] years) showed a female-to-male ratio of 2.3:1 whereas the gender ratio in elderly patients (n=378; median age, 75 [8] years) was almost even (1.2:1). Combinations of PAH drugs were widely used in both populations, albeit less frequently in older patients. Elderly patients were less likely to reach current treatment targets (6 min walking distance>400 m, functional class I or II). The survival rates 1, 2, and 3 years after the diagnosis of IPAH were lower in elderly patients, even when adjusted for age- and gender-matched survival tables of the general population (p=0.006 by log-rank analysis).CONCLUSIONS: In countries with an aging population, IPAH is now frequently diagnosed in elderly patients. Compared to younger patients, elderly patients present with a balanced gender ratio and different clinical features, respond less well to medical therapy and have a higher age-adjusted mortality. Further characterization of these patients is required. Clinical trials registration: NCT01347216.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Female

KW - Humans

KW - Hypertension, Pulmonary

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Registries

KW - Survival Rate

U2 - 10.1016/j.ijcard.2012.10.026

DO - 10.1016/j.ijcard.2012.10.026

M3 - SCORING: Journal article

C2 - 23164592

VL - 168

SP - 871

EP - 880

JO - INT J CARDIOL

JF - INT J CARDIOL

SN - 0167-5273

IS - 2

ER -