Eisenquantifizierung mittels MRT bei Eisenüberladung

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Eisenquantifizierung mittels MRT bei Eisenüberladung. / Schönnagel, B P; Fischer, R; Nielsen, P; Grosse, R; Adam, G; Yamamura, J.

In: ROFO-FORTSCHR RONTG, Vol. 185, No. 7, 01.07.2013, p. 621-7.

Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

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@article{e3c1cbd2460f4468af5b09b5e68e7b29,
title = "Eisenquantifizierung mittels MRT bei Eisen{\"u}berladung",
abstract = "Iron as an essential nutrient is involved in multiple metabolic activities. The importance of a sufficient iron supply is stressed by the fact that, according to WHO data, about 30 % of the global population suffers from iron deficiency and resulting anemia. In contrast, hereditary hemochromatosis is the most common monogeneous inherited disease (prevalence of homozygous genotype 1:200 - 300 in Germany). While iron-induced anemia can be handled by relatively simple diagnostic and therapeutic management, the diagnosis and quantification of organ iron overload is far more challenging. This is of great clinical impact, as the overall body and organ iron concentration is the crucial prognostic parameter in iron overload disease. In 2001 the international workshop of NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases) concluded that a quantitative, noninvasive, safe, and accurate approach for the assessment of body iron storage is needed to improve the diagnosis and management of patients with iron overload.",
keywords = "Algorithms, Humans, Iron, Iron Overload, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Tissue Distribution",
author = "Sch{\"o}nnagel, {B P} and R Fischer and P Nielsen and R Grosse and G Adam and J Yamamura",
note = "{\textcopyright} Georg Thieme Verlag KG Stuttgart · New York.",
year = "2013",
month = jul,
day = "1",
doi = "10.1055/s-0032-1330721",
language = "Deutsch",
volume = "185",
pages = "621--7",
journal = "ROFO-FORTSCHR RONTG",
issn = "1438-9029",
publisher = "Georg Thieme Verlag KG",
number = "7",

}

RIS

TY - JOUR

T1 - Eisenquantifizierung mittels MRT bei Eisenüberladung

AU - Schönnagel, B P

AU - Fischer, R

AU - Nielsen, P

AU - Grosse, R

AU - Adam, G

AU - Yamamura, J

N1 - © Georg Thieme Verlag KG Stuttgart · New York.

PY - 2013/7/1

Y1 - 2013/7/1

N2 - Iron as an essential nutrient is involved in multiple metabolic activities. The importance of a sufficient iron supply is stressed by the fact that, according to WHO data, about 30 % of the global population suffers from iron deficiency and resulting anemia. In contrast, hereditary hemochromatosis is the most common monogeneous inherited disease (prevalence of homozygous genotype 1:200 - 300 in Germany). While iron-induced anemia can be handled by relatively simple diagnostic and therapeutic management, the diagnosis and quantification of organ iron overload is far more challenging. This is of great clinical impact, as the overall body and organ iron concentration is the crucial prognostic parameter in iron overload disease. In 2001 the international workshop of NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases) concluded that a quantitative, noninvasive, safe, and accurate approach for the assessment of body iron storage is needed to improve the diagnosis and management of patients with iron overload.

AB - Iron as an essential nutrient is involved in multiple metabolic activities. The importance of a sufficient iron supply is stressed by the fact that, according to WHO data, about 30 % of the global population suffers from iron deficiency and resulting anemia. In contrast, hereditary hemochromatosis is the most common monogeneous inherited disease (prevalence of homozygous genotype 1:200 - 300 in Germany). While iron-induced anemia can be handled by relatively simple diagnostic and therapeutic management, the diagnosis and quantification of organ iron overload is far more challenging. This is of great clinical impact, as the overall body and organ iron concentration is the crucial prognostic parameter in iron overload disease. In 2001 the international workshop of NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases) concluded that a quantitative, noninvasive, safe, and accurate approach for the assessment of body iron storage is needed to improve the diagnosis and management of patients with iron overload.

KW - Algorithms

KW - Humans

KW - Iron

KW - Iron Overload

KW - Magnetic Resonance Imaging

KW - Magnetic Resonance Spectroscopy

KW - Tissue Distribution

U2 - 10.1055/s-0032-1330721

DO - 10.1055/s-0032-1330721

M3 - SCORING: Zeitschriftenaufsatz

C2 - 23450372

VL - 185

SP - 621

EP - 627

JO - ROFO-FORTSCHR RONTG

JF - ROFO-FORTSCHR RONTG

SN - 1438-9029

IS - 7

ER -