Eisenquantifizierung mittels MRT bei Eisenüberladung
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Eisenquantifizierung mittels MRT bei Eisenüberladung. / Schönnagel, B P; Fischer, R; Nielsen, P; Grosse, R; Adam, G; Yamamura, J.
In: ROFO-FORTSCHR RONTG, Vol. 185, No. 7, 01.07.2013, p. 621-7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Eisenquantifizierung mittels MRT bei Eisenüberladung
AU - Schönnagel, B P
AU - Fischer, R
AU - Nielsen, P
AU - Grosse, R
AU - Adam, G
AU - Yamamura, J
N1 - © Georg Thieme Verlag KG Stuttgart · New York.
PY - 2013/7/1
Y1 - 2013/7/1
N2 - Iron as an essential nutrient is involved in multiple metabolic activities. The importance of a sufficient iron supply is stressed by the fact that, according to WHO data, about 30 % of the global population suffers from iron deficiency and resulting anemia. In contrast, hereditary hemochromatosis is the most common monogeneous inherited disease (prevalence of homozygous genotype 1:200 - 300 in Germany). While iron-induced anemia can be handled by relatively simple diagnostic and therapeutic management, the diagnosis and quantification of organ iron overload is far more challenging. This is of great clinical impact, as the overall body and organ iron concentration is the crucial prognostic parameter in iron overload disease. In 2001 the international workshop of NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases) concluded that a quantitative, noninvasive, safe, and accurate approach for the assessment of body iron storage is needed to improve the diagnosis and management of patients with iron overload.
AB - Iron as an essential nutrient is involved in multiple metabolic activities. The importance of a sufficient iron supply is stressed by the fact that, according to WHO data, about 30 % of the global population suffers from iron deficiency and resulting anemia. In contrast, hereditary hemochromatosis is the most common monogeneous inherited disease (prevalence of homozygous genotype 1:200 - 300 in Germany). While iron-induced anemia can be handled by relatively simple diagnostic and therapeutic management, the diagnosis and quantification of organ iron overload is far more challenging. This is of great clinical impact, as the overall body and organ iron concentration is the crucial prognostic parameter in iron overload disease. In 2001 the international workshop of NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases) concluded that a quantitative, noninvasive, safe, and accurate approach for the assessment of body iron storage is needed to improve the diagnosis and management of patients with iron overload.
KW - Algorithms
KW - Humans
KW - Iron
KW - Iron Overload
KW - Magnetic Resonance Imaging
KW - Magnetic Resonance Spectroscopy
KW - Tissue Distribution
U2 - 10.1055/s-0032-1330721
DO - 10.1055/s-0032-1330721
M3 - SCORING: Zeitschriftenaufsatz
C2 - 23450372
VL - 185
SP - 621
EP - 627
JO - ROFO-FORTSCHR RONTG
JF - ROFO-FORTSCHR RONTG
SN - 1438-9029
IS - 7
ER -