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Efficacy of MMP-inhibiting wound dressings in the treatment of chronic wounds: a systematic review

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Efficacy of MMP-inhibiting wound dressings in the treatment of chronic wounds: a systematic review. / Dissemond, Joachim; Augustin, Matthias; Dietlein, Michael; Faust, Uta; Keuthage, Winfried; Lobmann, Ralf; Münter, Karl-Christian; Strohal, Robert; Stücker, Markus; Traber, Jürg; Vanscheidt, Wolfgang; Läuchli, Severin.

In: J WOUND CARE, Vol. 29, No. 2, 02.02.2020, p. 102-118.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dissemond, J, Augustin, M, Dietlein, M, Faust, U, Keuthage, W, Lobmann, R, Münter, K-C, Strohal, R, Stücker, M, Traber, J, Vanscheidt, W & Läuchli, S 2020, 'Efficacy of MMP-inhibiting wound dressings in the treatment of chronic wounds: a systematic review', J WOUND CARE, vol. 29, no. 2, pp. 102-118. https://doi.org/10.12968/jowc.2020.29.2.102

APA

Dissemond, J., Augustin, M., Dietlein, M., Faust, U., Keuthage, W., Lobmann, R., Münter, K-C., Strohal, R., Stücker, M., Traber, J., Vanscheidt, W., & Läuchli, S. (2020). Efficacy of MMP-inhibiting wound dressings in the treatment of chronic wounds: a systematic review. J WOUND CARE, 29(2), 102-118. https://doi.org/10.12968/jowc.2020.29.2.102

Vancouver

Dissemond J, Augustin M, Dietlein M, Faust U, Keuthage W, Lobmann R et al. Efficacy of MMP-inhibiting wound dressings in the treatment of chronic wounds: a systematic review. J WOUND CARE. 2020 Feb 2;29(2):102-118. https://doi.org/10.12968/jowc.2020.29.2.102

Bibtex

@article{d0b1bf735e5b43e9972feaa588710ab0,
title = "Efficacy of MMP-inhibiting wound dressings in the treatment of chronic wounds: a systematic review",
abstract = "OBJECTIVE: Matrix metalloproteinases (MMPs) substantially contribute to the development of chronicity in wounds. Thus, MMP-inhibiting dressings may support healing. A systematic review was performed to determine the existing evidence base for the treatment of hard-to-heal wounds with these dressings.METHODS: A systematic literature search in databases and clinical trial registers was conducted to identify randomised controlled trials (RCTs) investigating the efficacy of MMP-inhibiting dressings. Studies were analysed regarding their quality and clinical evidence.RESULTS: Of 721 hits, 16 relevant studies were assessed. There were 13 studies performed with collagen and three with technology lipido-colloid nano oligosaccharide factor (TLC-NOSF) dressings. Indications included diabetic foot ulcers, venous leg ulcers, pressure ulcers or wounds of mixed origin. Patient-relevant endpoints comprised wound size reduction, complete wound closure, healing time and rate. Considerable differences in the quality and subsequent clinical evidence exist between the studies identified. Substantial evidence for significant improvement in healing was identified only for some dressings.CONCLUSION: Evidence for the superiority of some MMP-inhibiting wound dressings exists regarding wound closure, wound size reduction, healing time and healing rate. More research is required to substantiate the existing evidence for different types of hard-to-heal wounds and to generate evidence for some of the different types of MMP-inhibiting wound dressings.",
keywords = "Bandages, Bandages, Hydrocolloid, Cellulose, Cellulose, Oxidized, Chronic Disease, Colloids/therapeutic use, Diabetic Foot/therapy, Humans, Matrix Metalloproteinase Inhibitors/therapeutic use, Matrix Metalloproteinases, Oligosaccharides/therapeutic use, Pressure Ulcer/therapy, Randomized Controlled Trials as Topic, Time Factors, Varicose Ulcer/therapy, Wound Healing, Wounds and Injuries/therapy",
author = "Joachim Dissemond and Matthias Augustin and Michael Dietlein and Uta Faust and Winfried Keuthage and Ralf Lobmann and Karl-Christian M{\"u}nter and Robert Strohal and Markus St{\"u}cker and J{\"u}rg Traber and Wolfgang Vanscheidt and Severin L{\"a}uchli",
year = "2020",
month = feb,
day = "2",
doi = "10.12968/jowc.2020.29.2.102",
language = "English",
volume = "29",
pages = "102--118",
journal = "J WOUND CARE",
issn = "0969-0700",
publisher = "MA Healthcare Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Efficacy of MMP-inhibiting wound dressings in the treatment of chronic wounds: a systematic review

AU - Dissemond, Joachim

AU - Augustin, Matthias

AU - Dietlein, Michael

AU - Faust, Uta

AU - Keuthage, Winfried

AU - Lobmann, Ralf

AU - Münter, Karl-Christian

AU - Strohal, Robert

AU - Stücker, Markus

AU - Traber, Jürg

AU - Vanscheidt, Wolfgang

AU - Läuchli, Severin

PY - 2020/2/2

Y1 - 2020/2/2

N2 - OBJECTIVE: Matrix metalloproteinases (MMPs) substantially contribute to the development of chronicity in wounds. Thus, MMP-inhibiting dressings may support healing. A systematic review was performed to determine the existing evidence base for the treatment of hard-to-heal wounds with these dressings.METHODS: A systematic literature search in databases and clinical trial registers was conducted to identify randomised controlled trials (RCTs) investigating the efficacy of MMP-inhibiting dressings. Studies were analysed regarding their quality and clinical evidence.RESULTS: Of 721 hits, 16 relevant studies were assessed. There were 13 studies performed with collagen and three with technology lipido-colloid nano oligosaccharide factor (TLC-NOSF) dressings. Indications included diabetic foot ulcers, venous leg ulcers, pressure ulcers or wounds of mixed origin. Patient-relevant endpoints comprised wound size reduction, complete wound closure, healing time and rate. Considerable differences in the quality and subsequent clinical evidence exist between the studies identified. Substantial evidence for significant improvement in healing was identified only for some dressings.CONCLUSION: Evidence for the superiority of some MMP-inhibiting wound dressings exists regarding wound closure, wound size reduction, healing time and healing rate. More research is required to substantiate the existing evidence for different types of hard-to-heal wounds and to generate evidence for some of the different types of MMP-inhibiting wound dressings.

AB - OBJECTIVE: Matrix metalloproteinases (MMPs) substantially contribute to the development of chronicity in wounds. Thus, MMP-inhibiting dressings may support healing. A systematic review was performed to determine the existing evidence base for the treatment of hard-to-heal wounds with these dressings.METHODS: A systematic literature search in databases and clinical trial registers was conducted to identify randomised controlled trials (RCTs) investigating the efficacy of MMP-inhibiting dressings. Studies were analysed regarding their quality and clinical evidence.RESULTS: Of 721 hits, 16 relevant studies were assessed. There were 13 studies performed with collagen and three with technology lipido-colloid nano oligosaccharide factor (TLC-NOSF) dressings. Indications included diabetic foot ulcers, venous leg ulcers, pressure ulcers or wounds of mixed origin. Patient-relevant endpoints comprised wound size reduction, complete wound closure, healing time and rate. Considerable differences in the quality and subsequent clinical evidence exist between the studies identified. Substantial evidence for significant improvement in healing was identified only for some dressings.CONCLUSION: Evidence for the superiority of some MMP-inhibiting wound dressings exists regarding wound closure, wound size reduction, healing time and healing rate. More research is required to substantiate the existing evidence for different types of hard-to-heal wounds and to generate evidence for some of the different types of MMP-inhibiting wound dressings.

KW - Bandages

KW - Bandages, Hydrocolloid

KW - Cellulose

KW - Cellulose, Oxidized

KW - Chronic Disease

KW - Colloids/therapeutic use

KW - Diabetic Foot/therapy

KW - Humans

KW - Matrix Metalloproteinase Inhibitors/therapeutic use

KW - Matrix Metalloproteinases

KW - Oligosaccharides/therapeutic use

KW - Pressure Ulcer/therapy

KW - Randomized Controlled Trials as Topic

KW - Time Factors

KW - Varicose Ulcer/therapy

KW - Wound Healing

KW - Wounds and Injuries/therapy

U2 - 10.12968/jowc.2020.29.2.102

DO - 10.12968/jowc.2020.29.2.102

M3 - SCORING: Journal article

C2 - 32058850

VL - 29

SP - 102

EP - 118

JO - J WOUND CARE

JF - J WOUND CARE

SN - 0969-0700

IS - 2

ER -