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Efficacy of Interpersonal Psychotherapy plus pharmacotherapy in chronically depressed inpatients.

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Efficacy of Interpersonal Psychotherapy plus pharmacotherapy in chronically depressed inpatients. / Schramm, Elisabeth; Schneider, Daniel; Zobel, Ingo; van Calker, Dietrich; Dykierek, Petra; Kech, Sabine; Härter, Martin; Berger, Mathias.

In: J AFFECT DISORDERS, Vol. 109, No. 1-2, 1-2, 2008, p. 65-73.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schramm, E, Schneider, D, Zobel, I, van Calker, D, Dykierek, P, Kech, S, Härter, M & Berger, M 2008, 'Efficacy of Interpersonal Psychotherapy plus pharmacotherapy in chronically depressed inpatients.', J AFFECT DISORDERS, vol. 109, no. 1-2, 1-2, pp. 65-73. <http://www.ncbi.nlm.nih.gov/pubmed/18067973?dopt=Citation>

APA

Schramm, E., Schneider, D., Zobel, I., van Calker, D., Dykierek, P., Kech, S., Härter, M., & Berger, M. (2008). Efficacy of Interpersonal Psychotherapy plus pharmacotherapy in chronically depressed inpatients. J AFFECT DISORDERS, 109(1-2), 65-73. [1-2]. http://www.ncbi.nlm.nih.gov/pubmed/18067973?dopt=Citation

Vancouver

Schramm E, Schneider D, Zobel I, van Calker D, Dykierek P, Kech S et al. Efficacy of Interpersonal Psychotherapy plus pharmacotherapy in chronically depressed inpatients. J AFFECT DISORDERS. 2008;109(1-2):65-73. 1-2.

Bibtex

@article{a0a4ff0ccf7d4445ab11aa54ef3f4a11,
title = "Efficacy of Interpersonal Psychotherapy plus pharmacotherapy in chronically depressed inpatients.",
abstract = "BACKGROUND: Clinical guidelines recommend the combination of pharmaco- and psychotherapy for the treatment of chronic depression, although there are only a few studies supporting an additive effect of psychotherapy. METHODS: Forty-five inpatients with a chronic Major Depressive Disorder were randomized to 5 weeks of either Interpersonal Psychotherapy (IPT) modified for an inpatient setting (15 individual and 8 group sessions) plus pharmacotherapy or to medication plus Clinical Management (CM). The 17-item Hamilton Rating Scale for Depression was the primary outcome measure. The study included a prospective naturalistic follow-up, 3- and 12-months after discharge. RESULTS: Intent-to-treat analyses revealed a significantly greater reduction of depressive symptoms as well as better global functioning of patients treated with IPT compared to the CM group at week 5. Response and sustained response rates differed significantly between the two treatment conditions, favouring the IPT group. Remission rates were considerably higher for IPT patients who completed the treatment (67% vs. 32%). Patients who initially responded to IPT exhibited greater treatment gains at 12 months since only 7% of these subjects relapsed compared with 25% of the CM subjects. In the long-term, additional IPT led to a lower symptom level and higher global functioning. LIMITATIONS: The study uses data of a subset of patients from a larger trial. Both treatment groups did not receive comparable amounts of therapeutic attention. Extrapolating the data from this inpatient study to chronically depressed outpatients may not be possible. CONCLUSIONS: Intensive combined treatment provides superior acute and long-term effects over standard treatment in chronically depressed inpatients.",
author = "Elisabeth Schramm and Daniel Schneider and Ingo Zobel and {van Calker}, Dietrich and Petra Dykierek and Sabine Kech and Martin H{\"a}rter and Mathias Berger",
year = "2008",
language = "Deutsch",
volume = "109",
pages = "65--73",
journal = "J AFFECT DISORDERS",
issn = "0165-0327",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Efficacy of Interpersonal Psychotherapy plus pharmacotherapy in chronically depressed inpatients.

AU - Schramm, Elisabeth

AU - Schneider, Daniel

AU - Zobel, Ingo

AU - van Calker, Dietrich

AU - Dykierek, Petra

AU - Kech, Sabine

AU - Härter, Martin

AU - Berger, Mathias

PY - 2008

Y1 - 2008

N2 - BACKGROUND: Clinical guidelines recommend the combination of pharmaco- and psychotherapy for the treatment of chronic depression, although there are only a few studies supporting an additive effect of psychotherapy. METHODS: Forty-five inpatients with a chronic Major Depressive Disorder were randomized to 5 weeks of either Interpersonal Psychotherapy (IPT) modified for an inpatient setting (15 individual and 8 group sessions) plus pharmacotherapy or to medication plus Clinical Management (CM). The 17-item Hamilton Rating Scale for Depression was the primary outcome measure. The study included a prospective naturalistic follow-up, 3- and 12-months after discharge. RESULTS: Intent-to-treat analyses revealed a significantly greater reduction of depressive symptoms as well as better global functioning of patients treated with IPT compared to the CM group at week 5. Response and sustained response rates differed significantly between the two treatment conditions, favouring the IPT group. Remission rates were considerably higher for IPT patients who completed the treatment (67% vs. 32%). Patients who initially responded to IPT exhibited greater treatment gains at 12 months since only 7% of these subjects relapsed compared with 25% of the CM subjects. In the long-term, additional IPT led to a lower symptom level and higher global functioning. LIMITATIONS: The study uses data of a subset of patients from a larger trial. Both treatment groups did not receive comparable amounts of therapeutic attention. Extrapolating the data from this inpatient study to chronically depressed outpatients may not be possible. CONCLUSIONS: Intensive combined treatment provides superior acute and long-term effects over standard treatment in chronically depressed inpatients.

AB - BACKGROUND: Clinical guidelines recommend the combination of pharmaco- and psychotherapy for the treatment of chronic depression, although there are only a few studies supporting an additive effect of psychotherapy. METHODS: Forty-five inpatients with a chronic Major Depressive Disorder were randomized to 5 weeks of either Interpersonal Psychotherapy (IPT) modified for an inpatient setting (15 individual and 8 group sessions) plus pharmacotherapy or to medication plus Clinical Management (CM). The 17-item Hamilton Rating Scale for Depression was the primary outcome measure. The study included a prospective naturalistic follow-up, 3- and 12-months after discharge. RESULTS: Intent-to-treat analyses revealed a significantly greater reduction of depressive symptoms as well as better global functioning of patients treated with IPT compared to the CM group at week 5. Response and sustained response rates differed significantly between the two treatment conditions, favouring the IPT group. Remission rates were considerably higher for IPT patients who completed the treatment (67% vs. 32%). Patients who initially responded to IPT exhibited greater treatment gains at 12 months since only 7% of these subjects relapsed compared with 25% of the CM subjects. In the long-term, additional IPT led to a lower symptom level and higher global functioning. LIMITATIONS: The study uses data of a subset of patients from a larger trial. Both treatment groups did not receive comparable amounts of therapeutic attention. Extrapolating the data from this inpatient study to chronically depressed outpatients may not be possible. CONCLUSIONS: Intensive combined treatment provides superior acute and long-term effects over standard treatment in chronically depressed inpatients.

M3 - SCORING: Zeitschriftenaufsatz

VL - 109

SP - 65

EP - 73

JO - J AFFECT DISORDERS

JF - J AFFECT DISORDERS

SN - 0165-0327

IS - 1-2

M1 - 1-2

ER -