Efficacy and side-effects of clozapine: testing for association with allelic variation in the dopamine D4 receptor gene.

M Rietschel; Dieter Naber; H Oberländer; R Holzbach; R Fimmers; K Eggermann; H J Möller; P Propping; M M Nöthen

Efficacy and side-effects of clozapine: testing for association with allelic variation in the dopamine D4 receptor gene.

Standard

Efficacy and side-effects of clozapine: testing for association with allelic variation in the dopamine D4 receptor gene. / Rietschel, M; Naber, Dieter; Oberländer, H; Holzbach, R; Fimmers, R; Eggermann, K; Möller, H J; Propping, P; Nöthen, M M.

In: NEUROPSYCHOPHARMACOL, Vol. 15, No. 5, 5, 1996, p. 491-496.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rietschel, M, Naber, D, Oberländer, H, Holzbach, R, Fimmers, R, Eggermann, K, Möller, HJ, Propping, P & Nöthen, MM 1996, 'Efficacy and side-effects of clozapine: testing for association with allelic variation in the dopamine D4 receptor gene.', NEUROPSYCHOPHARMACOL, vol. 15, no. 5, 5, pp. 491-496. <http://www.ncbi.nlm.nih.gov/pubmed/8914122?dopt=Citation>

APA

Rietschel, M., Naber, D., Oberländer, H., Holzbach, R., Fimmers, R., Eggermann, K., Möller, H. J., Propping, P., & Nöthen, M. M. (1996). Efficacy and side-effects of clozapine: testing for association with allelic variation in the dopamine D4 receptor gene. NEUROPSYCHOPHARMACOL, 15(5), 491-496. [5]. http://www.ncbi.nlm.nih.gov/pubmed/8914122?dopt=Citation

Vancouver

Rietschel M, Naber D, Oberländer H, Holzbach R, Fimmers R, Eggermann K et al. Efficacy and side-effects of clozapine: testing for association with allelic variation in the dopamine D4 receptor gene. NEUROPSYCHOPHARMACOL. 1996;15(5):491-496. 5.

Bibtex

@article{fe2fb64985334660a546dd73d7d9a533,

title = "Efficacy and side-effects of clozapine: testing for association with allelic variation in the dopamine D4 receptor gene.",

abstract = "Genetic factors are supposed to play a major role not only in the etiology of psychiatric disorders but also in individual response to medications. To test the hypothesis that inter-individual differences in response to clozapine and the occurrence of side-effects might be influenced by variations in the dopamine D4 receptor gene, we examined frequencies of four known polymorphic sites affecting protein structure in the dopamine D4 receptor gene in 149 patients with schizophrenia or schizoaffective disorder treated with clozapine. The D4 polymorphisms included a 13-base pair deletion, which through a frameshift leads to a truncated nonfunctional receptor protein. There were, however, no significant differences in genotype counts between responders and nonresponders. Furthermore, no side-effect was found to be associated with genetic variants of the dopamine D4 receptor.",

author = "M Rietschel and Dieter Naber and H Oberl{\"a}nder and R Holzbach and R Fimmers and K Eggermann and M{\"o}ller, {H J} and P Propping and N{\"o}then, {M M}",

year = "1996",

language = "Deutsch",

volume = "15",

pages = "491--496",

journal = "NEUROPSYCHOPHARMACOL",

issn = "0893-133X",

publisher = "NATURE PUBLISHING GROUP",

number = "5",

}

RIS

TY - JOUR

T1 - Efficacy and side-effects of clozapine: testing for association with allelic variation in the dopamine D4 receptor gene.

AU - Rietschel, M

AU - Naber, Dieter

AU - Oberländer, H

AU - Holzbach, R

AU - Fimmers, R

AU - Eggermann, K

AU - Möller, H J

AU - Propping, P

AU - Nöthen, M M

PY - 1996

Y1 - 1996

N2 - Genetic factors are supposed to play a major role not only in the etiology of psychiatric disorders but also in individual response to medications. To test the hypothesis that inter-individual differences in response to clozapine and the occurrence of side-effects might be influenced by variations in the dopamine D4 receptor gene, we examined frequencies of four known polymorphic sites affecting protein structure in the dopamine D4 receptor gene in 149 patients with schizophrenia or schizoaffective disorder treated with clozapine. The D4 polymorphisms included a 13-base pair deletion, which through a frameshift leads to a truncated nonfunctional receptor protein. There were, however, no significant differences in genotype counts between responders and nonresponders. Furthermore, no side-effect was found to be associated with genetic variants of the dopamine D4 receptor.

AB - Genetic factors are supposed to play a major role not only in the etiology of psychiatric disorders but also in individual response to medications. To test the hypothesis that inter-individual differences in response to clozapine and the occurrence of side-effects might be influenced by variations in the dopamine D4 receptor gene, we examined frequencies of four known polymorphic sites affecting protein structure in the dopamine D4 receptor gene in 149 patients with schizophrenia or schizoaffective disorder treated with clozapine. The D4 polymorphisms included a 13-base pair deletion, which through a frameshift leads to a truncated nonfunctional receptor protein. There were, however, no significant differences in genotype counts between responders and nonresponders. Furthermore, no side-effect was found to be associated with genetic variants of the dopamine D4 receptor.

M3 - SCORING: Zeitschriftenaufsatz

VL - 15

SP - 491

EP - 496

JO - NEUROPSYCHOPHARMACOL

JF - NEUROPSYCHOPHARMACOL

SN - 0893-133X

IS - 5

M1 - 5

ER -