Research ExplorerPublicationsEfficacy and side-effects of clozapine not associated with v...

Efficacy and side-effects of clozapine not associated with variation in the 5-HT2C receptor.

Standard

Efficacy and side-effects of clozapine not associated with variation in the 5-HT2C receptor. / Rietschel, M; Naber, Dieter; Fimmers, R; Möller, H J; Propping, P; Nöthen, M M.

In: NEUROREPORT, Vol. 8, No. 8, 8, 1997, p. 1999-2003.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rietschel, M, Naber, D, Fimmers, R, Möller, HJ, Propping, P & Nöthen, MM 1997, 'Efficacy and side-effects of clozapine not associated with variation in the 5-HT2C receptor.', NEUROREPORT, vol. 8, no. 8, 8, pp. 1999-2003. <http://www.ncbi.nlm.nih.gov/pubmed/9223092?dopt=Citation>

APA

Rietschel, M., Naber, D., Fimmers, R., Möller, H. J., Propping, P., & Nöthen, M. M. (1997). Efficacy and side-effects of clozapine not associated with variation in the 5-HT2C receptor. NEUROREPORT, 8(8), 1999-2003. [8]. http://www.ncbi.nlm.nih.gov/pubmed/9223092?dopt=Citation

Vancouver

Rietschel M, Naber D, Fimmers R, Möller HJ, Propping P, Nöthen MM. Efficacy and side-effects of clozapine not associated with variation in the 5-HT2C receptor. NEUROREPORT. 1997;8(8):1999-2003. 8.

Bibtex

@article{e7f1a874705646018a8411831d252feb,
title = "Efficacy and side-effects of clozapine not associated with variation in the 5-HT2C receptor.",
abstract = "In the present study we tested the hypothesis that individual response to clozapine treatment and/or the occurrence of side-effects may be influenced by genetic variation in the serotonin 5-HT2C receptor. We investigated the frequency of a common Cys23Ser substitution, which is known to alter the pharmacological properties of the protein, in 152 patients treated with clozapine. Presence of the Ser23 variant was previously reported to predict a good response to clozapine. However, our results did not support an association between genetic variation of the 5-HT2C receptor and response to clozapine. This held true whether the patients were subgrouped for sex and length of treatment. Moreover, we found no consistent association with any of the observed side-effects.",
author = "M Rietschel and Dieter Naber and R Fimmers and M{\"o}ller, {H J} and P Propping and N{\"o}then, {M M}",
year = "1997",
language = "Deutsch",
volume = "8",
pages = "1999--2003",
journal = "NEUROREPORT",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

RIS

TY - JOUR

T1 - Efficacy and side-effects of clozapine not associated with variation in the 5-HT2C receptor.

AU - Rietschel, M

AU - Naber, Dieter

AU - Fimmers, R

AU - Möller, H J

AU - Propping, P

AU - Nöthen, M M

PY - 1997

Y1 - 1997

N2 - In the present study we tested the hypothesis that individual response to clozapine treatment and/or the occurrence of side-effects may be influenced by genetic variation in the serotonin 5-HT2C receptor. We investigated the frequency of a common Cys23Ser substitution, which is known to alter the pharmacological properties of the protein, in 152 patients treated with clozapine. Presence of the Ser23 variant was previously reported to predict a good response to clozapine. However, our results did not support an association between genetic variation of the 5-HT2C receptor and response to clozapine. This held true whether the patients were subgrouped for sex and length of treatment. Moreover, we found no consistent association with any of the observed side-effects.

AB - In the present study we tested the hypothesis that individual response to clozapine treatment and/or the occurrence of side-effects may be influenced by genetic variation in the serotonin 5-HT2C receptor. We investigated the frequency of a common Cys23Ser substitution, which is known to alter the pharmacological properties of the protein, in 152 patients treated with clozapine. Presence of the Ser23 variant was previously reported to predict a good response to clozapine. However, our results did not support an association between genetic variation of the 5-HT2C receptor and response to clozapine. This held true whether the patients were subgrouped for sex and length of treatment. Moreover, we found no consistent association with any of the observed side-effects.

M3 - SCORING: Zeitschriftenaufsatz

VL - 8

SP - 1999

EP - 2003

JO - NEUROREPORT

JF - NEUROREPORT

SN - 0959-4965

IS - 8

M1 - 8

ER -