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Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding.

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Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding. / Dorfmeister, B; Zeng, W W; Dichlberger, A; Nilsson, S K; Schaap, F G; Hubacek, J A; Merkel, Martin; Cooper, J A; Lookene, A; Putt, W; Whittall, R; Lee, P J; Lins, L; Delsaux, N; Nierman, M; Kuivenhoven, J A; Kastelein, J J P; Vrablik, M; Olivecrona, G; Schneider, W J; Heeren, Jörg; Humphries, S E; Talmud, P J.

In: ARTERIOSCL THROM VAS, Vol. 28, No. 10, 10, 2008, p. 1866-1871.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dorfmeister, B, Zeng, WW, Dichlberger, A, Nilsson, SK, Schaap, FG, Hubacek, JA, Merkel, M, Cooper, JA, Lookene, A, Putt, W, Whittall, R, Lee, PJ, Lins, L, Delsaux, N, Nierman, M, Kuivenhoven, JA, Kastelein, JJP, Vrablik, M, Olivecrona, G, Schneider, WJ, Heeren, J, Humphries, SE & Talmud, PJ 2008, 'Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding.', ARTERIOSCL THROM VAS, vol. 28, no. 10, 10, pp. 1866-1871. <http://www.ncbi.nlm.nih.gov/pubmed/18635818?dopt=Citation>

APA

Dorfmeister, B., Zeng, W. W., Dichlberger, A., Nilsson, S. K., Schaap, F. G., Hubacek, J. A., Merkel, M., Cooper, J. A., Lookene, A., Putt, W., Whittall, R., Lee, P. J., Lins, L., Delsaux, N., Nierman, M., Kuivenhoven, J. A., Kastelein, J. J. P., Vrablik, M., Olivecrona, G., ... Talmud, P. J. (2008). Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding. ARTERIOSCL THROM VAS, 28(10), 1866-1871. [10]. http://www.ncbi.nlm.nih.gov/pubmed/18635818?dopt=Citation

Vancouver

Dorfmeister B, Zeng WW, Dichlberger A, Nilsson SK, Schaap FG, Hubacek JA et al. Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding. ARTERIOSCL THROM VAS. 2008;28(10):1866-1871. 10.

Bibtex

@article{c7bce9a0f2804295b0674703dc073d1d,
title = "Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding.",
abstract = "OBJECTIVE: The purpose of this study was to identify rare APOA5 variants in 130 severe hypertriglyceridemic patients by sequencing, and to test their functionality, since no patient recall was possible. METHODS AND RESULTS: We studied the impact in vitro on LPL activity and receptor binding of 3 novel heterozygous variants, apoAV-E255G, -G271C, and -H321L, together with the previously reported -G185C, -Q139X, -Q148X, and a novel construct -Delta139 to 147. Using VLDL as a TG-source, compared to wild type, apoAV-G255, -L321 and -C185 showed reduced LPL activation (-25% [P=0.005], -36% [P",
author = "B Dorfmeister and Zeng, {W W} and A Dichlberger and Nilsson, {S K} and Schaap, {F G} and Hubacek, {J A} and Martin Merkel and Cooper, {J A} and A Lookene and W Putt and R Whittall and Lee, {P J} and L Lins and N Delsaux and M Nierman and Kuivenhoven, {J A} and Kastelein, {J J P} and M Vrablik and G Olivecrona and Schneider, {W J} and J{\"o}rg Heeren and Humphries, {S E} and Talmud, {P J}",
year = "2008",
language = "Deutsch",
volume = "28",
pages = "1866--1871",
journal = "ARTERIOSCL THROM VAS",
issn = "1079-5642",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

RIS

TY - JOUR

T1 - Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding.

AU - Dorfmeister, B

AU - Zeng, W W

AU - Dichlberger, A

AU - Nilsson, S K

AU - Schaap, F G

AU - Hubacek, J A

AU - Merkel, Martin

AU - Cooper, J A

AU - Lookene, A

AU - Putt, W

AU - Whittall, R

AU - Lee, P J

AU - Lins, L

AU - Delsaux, N

AU - Nierman, M

AU - Kuivenhoven, J A

AU - Kastelein, J J P

AU - Vrablik, M

AU - Olivecrona, G

AU - Schneider, W J

AU - Heeren, Jörg

AU - Humphries, S E

AU - Talmud, P J

PY - 2008

Y1 - 2008

N2 - OBJECTIVE: The purpose of this study was to identify rare APOA5 variants in 130 severe hypertriglyceridemic patients by sequencing, and to test their functionality, since no patient recall was possible. METHODS AND RESULTS: We studied the impact in vitro on LPL activity and receptor binding of 3 novel heterozygous variants, apoAV-E255G, -G271C, and -H321L, together with the previously reported -G185C, -Q139X, -Q148X, and a novel construct -Delta139 to 147. Using VLDL as a TG-source, compared to wild type, apoAV-G255, -L321 and -C185 showed reduced LPL activation (-25% [P=0.005], -36% [P

AB - OBJECTIVE: The purpose of this study was to identify rare APOA5 variants in 130 severe hypertriglyceridemic patients by sequencing, and to test their functionality, since no patient recall was possible. METHODS AND RESULTS: We studied the impact in vitro on LPL activity and receptor binding of 3 novel heterozygous variants, apoAV-E255G, -G271C, and -H321L, together with the previously reported -G185C, -Q139X, -Q148X, and a novel construct -Delta139 to 147. Using VLDL as a TG-source, compared to wild type, apoAV-G255, -L321 and -C185 showed reduced LPL activation (-25% [P=0.005], -36% [P

M3 - SCORING: Zeitschriftenaufsatz

VL - 28

SP - 1866

EP - 1871

JO - ARTERIOSCL THROM VAS

JF - ARTERIOSCL THROM VAS

SN - 1079-5642

IS - 10

M1 - 10

ER -