Effects of renal denervation on heart failure biomarkers and blood pressure in patients with resistant hypertension
Related Research units
Abstract
AIM: This multicenter study investigated the effect of renal denervation therapy (RDN) on the heart failure related biomarkers NT-proBNP, ST-2, galectin-3 and hs-TnI.
PATIENTS & METHODS: We included 157 patients with resistant hypertension undergoing RDN. Blood sampling was performed before and 6 months after RDN.
RESULTS: Six months after RDN systolic blood pressure (BP) was reduced by 24 mmHg. Biomarker concentrations were not changed after RDN, except a small increase of hs-TnI by 0.3 pg/ml. In individuals with high baseline BP, we observed a BP reduction of 45 mmHg and a decrease of hs-TnI concentrations by 1.2 pg/ml.
CONCLUSION: In this multicenter analysis RDN did significantly reduce systolic BP. However, NT-proBNP, ST-2, galectin-3 and hs-TnI did not correspond to BP reduction 6 months after RDN.
Bibliographical data
Original language | English |
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ISSN | 1752-0363 |
DOIs | |
Publication status | Published - 08.2016 |
PubMed | 27428075 |
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