Effects of Infantile Hypophosphatasia on Human Dental Tissue
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Effects of Infantile Hypophosphatasia on Human Dental Tissue. / Wölfel, Eva Maria; von Kroge, Simon; Matthies, Levi; Köhne, Till; Petz, Karin; Beikler, Thomas; Schmid-Herrmann, Carmen; Kahl-Nieke, Bärbel; Tsiakas, Konstantinos; Santer, Rene; Muschol, Nicole Maria; Herrmann, Jochen; Busse, Björn; Amling, Michael; Rolvien, Tim; Jandl, Nico Maximilian; Barvencik, Florian.
In: CALCIFIED TISSUE INT, Vol. 112, No. 3, 03.2023, p. 308-319.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of Infantile Hypophosphatasia on Human Dental Tissue
AU - Wölfel, Eva Maria
AU - von Kroge, Simon
AU - Matthies, Levi
AU - Köhne, Till
AU - Petz, Karin
AU - Beikler, Thomas
AU - Schmid-Herrmann, Carmen
AU - Kahl-Nieke, Bärbel
AU - Tsiakas, Konstantinos
AU - Santer, Rene
AU - Muschol, Nicole Maria
AU - Herrmann, Jochen
AU - Busse, Björn
AU - Amling, Michael
AU - Rolvien, Tim
AU - Jandl, Nico Maximilian
AU - Barvencik, Florian
PY - 2023/3
Y1 - 2023/3
N2 - Hypophosphatasia (HPP) is an inherited, systemic disorder, caused by loss-of-function variants of the ALPL gene encoding the enzyme tissue non-specific alkaline phosphatase (TNSALP). HPP is characterized by low serum TNSALP concentrations associated with defective bone mineralization and increased fracture risk. Dental manifestations have been reported as the exclusive feature (odontohypophosphatasia) and in combination with skeletal complications. Enzyme replacement therapy (asfotase alfa) has been shown to improve respiratory insufficiency and skeletal complications in HPP patients, while its effects on dental status have been understudied to date. In this study, quantitative backscattered electron imaging (qBEI) and histological analysis were performed on teeth from two patients with infantile HPP before and during asfotase alfa treatment and compared to matched healthy control teeth. qBEI and histological methods revealed varying mineralization patterns in cementum and dentin with lower mineralization in HPP. Furthermore, a significantly higher repair cementum thickness was observed in HPP compared to control teeth. Comparison before and during treatment showed minor improvements in mineralization and histological parameters in the patient when normalized to matched control teeth. HPP induces heterogeneous effects on mineralization and morphology of the dental status. Short treatment with asfotase alfa slightly affects mineralization in cementum and dentin. Despite HPP being a rare disease, its mild form occurs at higher prevalence. This study is of high clinical relevance as it expands our knowledge of HPP and dental involvement. Furthermore, it contributes to the understanding of dental tissue treatment, which has hardly been studied so far.
AB - Hypophosphatasia (HPP) is an inherited, systemic disorder, caused by loss-of-function variants of the ALPL gene encoding the enzyme tissue non-specific alkaline phosphatase (TNSALP). HPP is characterized by low serum TNSALP concentrations associated with defective bone mineralization and increased fracture risk. Dental manifestations have been reported as the exclusive feature (odontohypophosphatasia) and in combination with skeletal complications. Enzyme replacement therapy (asfotase alfa) has been shown to improve respiratory insufficiency and skeletal complications in HPP patients, while its effects on dental status have been understudied to date. In this study, quantitative backscattered electron imaging (qBEI) and histological analysis were performed on teeth from two patients with infantile HPP before and during asfotase alfa treatment and compared to matched healthy control teeth. qBEI and histological methods revealed varying mineralization patterns in cementum and dentin with lower mineralization in HPP. Furthermore, a significantly higher repair cementum thickness was observed in HPP compared to control teeth. Comparison before and during treatment showed minor improvements in mineralization and histological parameters in the patient when normalized to matched control teeth. HPP induces heterogeneous effects on mineralization and morphology of the dental status. Short treatment with asfotase alfa slightly affects mineralization in cementum and dentin. Despite HPP being a rare disease, its mild form occurs at higher prevalence. This study is of high clinical relevance as it expands our knowledge of HPP and dental involvement. Furthermore, it contributes to the understanding of dental tissue treatment, which has hardly been studied so far.
U2 - 10.1007/s00223-022-01041-4
DO - 10.1007/s00223-022-01041-4
M3 - SCORING: Journal article
C2 - 36414794
VL - 112
SP - 308
EP - 319
JO - CALCIFIED TISSUE INT
JF - CALCIFIED TISSUE INT
SN - 0171-967X
IS - 3
ER -
