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Effects of hydroxyethyl starch and cell-free hemoglobin on microcirculation, tissue oxygenation, and survival in severe acute porcine pancreatitis

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Effects of hydroxyethyl starch and cell-free hemoglobin on microcirculation, tissue oxygenation, and survival in severe acute porcine pancreatitis : results of a randomized experimental trial. / Bachmann, Kai; Freitag, Marc; Lohalm, Hendrik; Tomkötter, Lena; Dupree, Anna; Koops, Susan; Strate, Tim; Izbicki, Jakob R; Mann, Oliver.

In: PANCREAS, Vol. 43, No. 6, 08.2014, p. 855-62.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bachmann, K, Freitag, M, Lohalm, H, Tomkötter, L, Dupree, A, Koops, S, Strate, T, Izbicki, JR & Mann, O 2014, 'Effects of hydroxyethyl starch and cell-free hemoglobin on microcirculation, tissue oxygenation, and survival in severe acute porcine pancreatitis: results of a randomized experimental trial', PANCREAS, vol. 43, no. 6, pp. 855-62. https://doi.org/10.1097/MPA.0000000000000146

APA

Bachmann, K., Freitag, M., Lohalm, H., Tomkötter, L., Dupree, A., Koops, S., Strate, T., Izbicki, J. R., & Mann, O. (2014). Effects of hydroxyethyl starch and cell-free hemoglobin on microcirculation, tissue oxygenation, and survival in severe acute porcine pancreatitis: results of a randomized experimental trial. PANCREAS, 43(6), 855-62. https://doi.org/10.1097/MPA.0000000000000146

Vancouver

Bachmann K, Freitag M, Lohalm H, Tomkötter L, Dupree A, Koops S et al. Effects of hydroxyethyl starch and cell-free hemoglobin on microcirculation, tissue oxygenation, and survival in severe acute porcine pancreatitis: results of a randomized experimental trial. PANCREAS. 2014 Aug;43(6):855-62. https://doi.org/10.1097/MPA.0000000000000146

Bibtex

@article{79d67c62eb014acea67fe7026265d045,
title = "Effects of hydroxyethyl starch and cell-free hemoglobin on microcirculation, tissue oxygenation, and survival in severe acute porcine pancreatitis: results of a randomized experimental trial",
abstract = "OBJECTIVE: Severe acute pancreatitis is a life-threatening disease with a high mortality; so far, no causal treatment is known. The aim of this study was to evaluate the therapeutic potential of hydroxyethyl starch (HES) and cell-free hemoglobin in an experimental model.METHODS: Thirty-nine pigs were randomly assigned into 3 groups. Severe acute pancreatitis was induced by intraductal injection of glycodeoxycholic acid in combination with intravenous administration of cerulein. All animals were kept in isovolemic conditions by application of Ringer solution, 10% HES, or cell-free hemoglobin. The pancreatic microcirculation was evaluated over 8 hours. Thereafter, the animals were observed for 6 days followed by killing of the animals and histopathologic examination.RESULTS: The administration of HES and cell-free hemoglobin led to improved microcirculation and tissue oxygenation compared with the Ringer's group. Consequently, the histopathologic damage was reduced (5.5 [3-8.5] vs 9.5 [7.5-11]; P < 0.001). In addition, the mean survival was significantly longer at 121 hours (95% confidence interval, 102-139) versus the Ringer group's 57 hours (95% confidence interval, 32-82; P < 0.001).CONCLUSIONS: The administration of HES and cell-free hemoglobin can improve microcirculation in severe acute porcine pancreatitis, with consequent reduction in histopathologic damage and mortality. Therefore, this might represent an interesting therapeutic option in the treatment of severe acute pancreatitis.",
keywords = "Acute Disease, Animals, Ceruletide, Glycodeoxycholic Acid, Hemoglobins/administration & dosage, Hydroxyethyl Starch Derivatives/administration & dosage, Isotonic Solutions/administration & dosage, Microcirculation/drug effects, Oxygen Consumption/drug effects, Pancreas/drug effects, Pancreatitis/chemically induced, Random Allocation, Ringer's Solution, Severity of Illness Index, Survival Analysis, Swine, Treatment Outcome",
author = "Kai Bachmann and Marc Freitag and Hendrik Lohalm and Lena Tomk{\"o}tter and Anna Dupree and Susan Koops and Tim Strate and Izbicki, {Jakob R} and Oliver Mann",
year = "2014",
month = aug,
doi = "10.1097/MPA.0000000000000146",
language = "English",
volume = "43",
pages = "855--62",
journal = "PANCREAS",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

RIS

TY - JOUR

T1 - Effects of hydroxyethyl starch and cell-free hemoglobin on microcirculation, tissue oxygenation, and survival in severe acute porcine pancreatitis

T2 - results of a randomized experimental trial

AU - Bachmann, Kai

AU - Freitag, Marc

AU - Lohalm, Hendrik

AU - Tomkötter, Lena

AU - Dupree, Anna

AU - Koops, Susan

AU - Strate, Tim

AU - Izbicki, Jakob R

AU - Mann, Oliver

PY - 2014/8

Y1 - 2014/8

N2 - OBJECTIVE: Severe acute pancreatitis is a life-threatening disease with a high mortality; so far, no causal treatment is known. The aim of this study was to evaluate the therapeutic potential of hydroxyethyl starch (HES) and cell-free hemoglobin in an experimental model.METHODS: Thirty-nine pigs were randomly assigned into 3 groups. Severe acute pancreatitis was induced by intraductal injection of glycodeoxycholic acid in combination with intravenous administration of cerulein. All animals were kept in isovolemic conditions by application of Ringer solution, 10% HES, or cell-free hemoglobin. The pancreatic microcirculation was evaluated over 8 hours. Thereafter, the animals were observed for 6 days followed by killing of the animals and histopathologic examination.RESULTS: The administration of HES and cell-free hemoglobin led to improved microcirculation and tissue oxygenation compared with the Ringer's group. Consequently, the histopathologic damage was reduced (5.5 [3-8.5] vs 9.5 [7.5-11]; P < 0.001). In addition, the mean survival was significantly longer at 121 hours (95% confidence interval, 102-139) versus the Ringer group's 57 hours (95% confidence interval, 32-82; P < 0.001).CONCLUSIONS: The administration of HES and cell-free hemoglobin can improve microcirculation in severe acute porcine pancreatitis, with consequent reduction in histopathologic damage and mortality. Therefore, this might represent an interesting therapeutic option in the treatment of severe acute pancreatitis.

AB - OBJECTIVE: Severe acute pancreatitis is a life-threatening disease with a high mortality; so far, no causal treatment is known. The aim of this study was to evaluate the therapeutic potential of hydroxyethyl starch (HES) and cell-free hemoglobin in an experimental model.METHODS: Thirty-nine pigs were randomly assigned into 3 groups. Severe acute pancreatitis was induced by intraductal injection of glycodeoxycholic acid in combination with intravenous administration of cerulein. All animals were kept in isovolemic conditions by application of Ringer solution, 10% HES, or cell-free hemoglobin. The pancreatic microcirculation was evaluated over 8 hours. Thereafter, the animals were observed for 6 days followed by killing of the animals and histopathologic examination.RESULTS: The administration of HES and cell-free hemoglobin led to improved microcirculation and tissue oxygenation compared with the Ringer's group. Consequently, the histopathologic damage was reduced (5.5 [3-8.5] vs 9.5 [7.5-11]; P < 0.001). In addition, the mean survival was significantly longer at 121 hours (95% confidence interval, 102-139) versus the Ringer group's 57 hours (95% confidence interval, 32-82; P < 0.001).CONCLUSIONS: The administration of HES and cell-free hemoglobin can improve microcirculation in severe acute porcine pancreatitis, with consequent reduction in histopathologic damage and mortality. Therefore, this might represent an interesting therapeutic option in the treatment of severe acute pancreatitis.

KW - Acute Disease

KW - Animals

KW - Ceruletide

KW - Glycodeoxycholic Acid

KW - Hemoglobins/administration & dosage

KW - Hydroxyethyl Starch Derivatives/administration & dosage

KW - Isotonic Solutions/administration & dosage

KW - Microcirculation/drug effects

KW - Oxygen Consumption/drug effects

KW - Pancreas/drug effects

KW - Pancreatitis/chemically induced

KW - Random Allocation

KW - Ringer's Solution

KW - Severity of Illness Index

KW - Survival Analysis

KW - Swine

KW - Treatment Outcome

U2 - 10.1097/MPA.0000000000000146

DO - 10.1097/MPA.0000000000000146

M3 - SCORING: Journal article

C2 - 24809409

VL - 43

SP - 855

EP - 862

JO - PANCREAS

JF - PANCREAS

SN - 0885-3177

IS - 6

ER -