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Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence

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Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence. / Wang, Qin; Würtz, Peter; Auro, Kirsi; Morin-Papunen, Laure; Kangas, Antti J; Soininen, Pasi; Tiainen, Mika; Tynkkynen, Tuulia; Joensuu, Anni; Havulinna, Aki S; Aalto, Kristiina; Salmi, Marko; Blankenberg, Stefan; Zeller, Tanja; Viikari, Jorma; Kähönen, Mika; Lehtimäki, Terho; Salomaa, Veikko; Jalkanen, Sirpa; Järvelin, Marjo-Riitta; Perola, Markus; Raitakari, Olli T; Lawlor, Debbie A; Kettunen, Johannes; Ala-Korpela, Mika.

In: INT J EPIDEMIOL, Vol. 45, No. 5, 10.2016, p. 1445-1457.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wang, Q, Würtz, P, Auro, K, Morin-Papunen, L, Kangas, AJ, Soininen, P, Tiainen, M, Tynkkynen, T, Joensuu, A, Havulinna, AS, Aalto, K, Salmi, M, Blankenberg, S, Zeller, T, Viikari, J, Kähönen, M, Lehtimäki, T, Salomaa, V, Jalkanen, S, Järvelin, M-R, Perola, M, Raitakari, OT, Lawlor, DA, Kettunen, J & Ala-Korpela, M 2016, 'Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence', INT J EPIDEMIOL, vol. 45, no. 5, pp. 1445-1457. https://doi.org/10.1093/ije/dyw147

APA

Wang, Q., Würtz, P., Auro, K., Morin-Papunen, L., Kangas, A. J., Soininen, P., Tiainen, M., Tynkkynen, T., Joensuu, A., Havulinna, A. S., Aalto, K., Salmi, M., Blankenberg, S., Zeller, T., Viikari, J., Kähönen, M., Lehtimäki, T., Salomaa, V., Jalkanen, S., ... Ala-Korpela, M. (2016). Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence. INT J EPIDEMIOL, 45(5), 1445-1457. https://doi.org/10.1093/ije/dyw147

Vancouver

Wang Q, Würtz P, Auro K, Morin-Papunen L, Kangas AJ, Soininen P et al. Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence. INT J EPIDEMIOL. 2016 Oct;45(5):1445-1457. https://doi.org/10.1093/ije/dyw147

Bibtex

@article{1818ed5300754532b91d6ffa826b7b43,
title = "Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence",
abstract = "BACKGROUND: Hormonal contraception is commonly used worldwide, but its systemic effects across lipoprotein subclasses, fatty acids, circulating metabolites and cytokines remain poorly understood.METHODS: A comprehensive molecular profile (75 metabolic measures and 37 cytokines) was measured for up to 5841 women (age range 24-49 years) from three population-based cohorts. Women using combined oral contraceptive pills (COCPs) or progestin-only contraceptives (POCs) were compared with those who did not use hormonal contraception. Metabolomics profiles were reassessed for 869 women after 6 years to uncover the metabolic effects of starting, stopping and persistently using hormonal contraception.RESULTS: The comprehensive molecular profiling allowed multiple new findings on the metabolic associations with the use of COCPs. They were positively associated with lipoprotein subclasses, including all high-density lipoprotein (HDL) subclasses. The associations with fatty acids and amino acids were strong and variable in direction. COCP use was negatively associated with albumin and positively associated with creatinine and inflammatory markers, including glycoprotein acetyls and several growth factors and interleukins. Our findings also confirmed previous results e.g. for increased circulating triglycerides and HDL cholesterol. Starting COCPs caused similar metabolic changes to those observed cross-sectionally: the changes were maintained in consistent users and normalized in those who stopped using. In contrast, POCs were only weakly associated with metabolic and inflammatory markers. Results were consistent across all cohorts and for different COCP preparations and different types of POC delivery.CONCLUSIONS: Use of COCPs causes widespread metabolic and inflammatory effects. However, persistent use does not appear to accumulate the effects over time and the metabolic perturbations are reversed upon discontinuation. POCs have little effect on systemic metabolism and inflammation.",
keywords = "Adult, Cholesterol, HDL/blood, Contraceptives, Oral, Hormonal/pharmacology, Cross-Sectional Studies, Cytokines/blood, Fatty Acids/blood, Female, Finland, Humans, Linear Models, Longitudinal Studies, Metabolome/drug effects, Metabolomics, Progestins/pharmacology, Risk Factors, Triglycerides/blood, Young Adult",
author = "Qin Wang and Peter W{\"u}rtz and Kirsi Auro and Laure Morin-Papunen and Kangas, {Antti J} and Pasi Soininen and Mika Tiainen and Tuulia Tynkkynen and Anni Joensuu and Havulinna, {Aki S} and Kristiina Aalto and Marko Salmi and Stefan Blankenberg and Tanja Zeller and Jorma Viikari and Mika K{\"a}h{\"o}nen and Terho Lehtim{\"a}ki and Veikko Salomaa and Sirpa Jalkanen and Marjo-Riitta J{\"a}rvelin and Markus Perola and Raitakari, {Olli T} and Lawlor, {Debbie A} and Johannes Kettunen and Mika Ala-Korpela",
note = "{\textcopyright} The Author 2016. Published by Oxford University Press on behalf of the International Epidemiological Association.",
year = "2016",
month = oct,
doi = "10.1093/ije/dyw147",
language = "English",
volume = "45",
pages = "1445--1457",
journal = "INT J EPIDEMIOL",
issn = "0300-5771",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence

AU - Wang, Qin

AU - Würtz, Peter

AU - Auro, Kirsi

AU - Morin-Papunen, Laure

AU - Kangas, Antti J

AU - Soininen, Pasi

AU - Tiainen, Mika

AU - Tynkkynen, Tuulia

AU - Joensuu, Anni

AU - Havulinna, Aki S

AU - Aalto, Kristiina

AU - Salmi, Marko

AU - Blankenberg, Stefan

AU - Zeller, Tanja

AU - Viikari, Jorma

AU - Kähönen, Mika

AU - Lehtimäki, Terho

AU - Salomaa, Veikko

AU - Jalkanen, Sirpa

AU - Järvelin, Marjo-Riitta

AU - Perola, Markus

AU - Raitakari, Olli T

AU - Lawlor, Debbie A

AU - Kettunen, Johannes

AU - Ala-Korpela, Mika

N1 - © The Author 2016. Published by Oxford University Press on behalf of the International Epidemiological Association.

PY - 2016/10

Y1 - 2016/10

N2 - BACKGROUND: Hormonal contraception is commonly used worldwide, but its systemic effects across lipoprotein subclasses, fatty acids, circulating metabolites and cytokines remain poorly understood.METHODS: A comprehensive molecular profile (75 metabolic measures and 37 cytokines) was measured for up to 5841 women (age range 24-49 years) from three population-based cohorts. Women using combined oral contraceptive pills (COCPs) or progestin-only contraceptives (POCs) were compared with those who did not use hormonal contraception. Metabolomics profiles were reassessed for 869 women after 6 years to uncover the metabolic effects of starting, stopping and persistently using hormonal contraception.RESULTS: The comprehensive molecular profiling allowed multiple new findings on the metabolic associations with the use of COCPs. They were positively associated with lipoprotein subclasses, including all high-density lipoprotein (HDL) subclasses. The associations with fatty acids and amino acids were strong and variable in direction. COCP use was negatively associated with albumin and positively associated with creatinine and inflammatory markers, including glycoprotein acetyls and several growth factors and interleukins. Our findings also confirmed previous results e.g. for increased circulating triglycerides and HDL cholesterol. Starting COCPs caused similar metabolic changes to those observed cross-sectionally: the changes were maintained in consistent users and normalized in those who stopped using. In contrast, POCs were only weakly associated with metabolic and inflammatory markers. Results were consistent across all cohorts and for different COCP preparations and different types of POC delivery.CONCLUSIONS: Use of COCPs causes widespread metabolic and inflammatory effects. However, persistent use does not appear to accumulate the effects over time and the metabolic perturbations are reversed upon discontinuation. POCs have little effect on systemic metabolism and inflammation.

AB - BACKGROUND: Hormonal contraception is commonly used worldwide, but its systemic effects across lipoprotein subclasses, fatty acids, circulating metabolites and cytokines remain poorly understood.METHODS: A comprehensive molecular profile (75 metabolic measures and 37 cytokines) was measured for up to 5841 women (age range 24-49 years) from three population-based cohorts. Women using combined oral contraceptive pills (COCPs) or progestin-only contraceptives (POCs) were compared with those who did not use hormonal contraception. Metabolomics profiles were reassessed for 869 women after 6 years to uncover the metabolic effects of starting, stopping and persistently using hormonal contraception.RESULTS: The comprehensive molecular profiling allowed multiple new findings on the metabolic associations with the use of COCPs. They were positively associated with lipoprotein subclasses, including all high-density lipoprotein (HDL) subclasses. The associations with fatty acids and amino acids were strong and variable in direction. COCP use was negatively associated with albumin and positively associated with creatinine and inflammatory markers, including glycoprotein acetyls and several growth factors and interleukins. Our findings also confirmed previous results e.g. for increased circulating triglycerides and HDL cholesterol. Starting COCPs caused similar metabolic changes to those observed cross-sectionally: the changes were maintained in consistent users and normalized in those who stopped using. In contrast, POCs were only weakly associated with metabolic and inflammatory markers. Results were consistent across all cohorts and for different COCP preparations and different types of POC delivery.CONCLUSIONS: Use of COCPs causes widespread metabolic and inflammatory effects. However, persistent use does not appear to accumulate the effects over time and the metabolic perturbations are reversed upon discontinuation. POCs have little effect on systemic metabolism and inflammation.

KW - Adult

KW - Cholesterol, HDL/blood

KW - Contraceptives, Oral, Hormonal/pharmacology

KW - Cross-Sectional Studies

KW - Cytokines/blood

KW - Fatty Acids/blood

KW - Female

KW - Finland

KW - Humans

KW - Linear Models

KW - Longitudinal Studies

KW - Metabolome/drug effects

KW - Metabolomics

KW - Progestins/pharmacology

KW - Risk Factors

KW - Triglycerides/blood

KW - Young Adult

U2 - 10.1093/ije/dyw147

DO - 10.1093/ije/dyw147

M3 - SCORING: Journal article

C2 - 27538888

VL - 45

SP - 1445

EP - 1457

JO - INT J EPIDEMIOL

JF - INT J EPIDEMIOL

SN - 0300-5771

IS - 5

ER -