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Effects of Cigarette Smoking on Plasma Concentration of the Appetite-Regulating Peptide Ghrelin

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Effects of Cigarette Smoking on Plasma Concentration of the Appetite-Regulating Peptide Ghrelin. / Koopmann, Anne; Bez, Jennifer; Lemenager, Tagrid; Hermann, Derik; Dinter, Christina; Reinhard, Iris; Hoffmann, Heiko; Wiedemann, Klaus; Winterer, Georg; Kiefer, Falk.

In: ANN NUTR METAB, Vol. 66, No. 2-3, 2015, p. 155-61.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Koopmann, A, Bez, J, Lemenager, T, Hermann, D, Dinter, C, Reinhard, I, Hoffmann, H, Wiedemann, K, Winterer, G & Kiefer, F 2015, 'Effects of Cigarette Smoking on Plasma Concentration of the Appetite-Regulating Peptide Ghrelin', ANN NUTR METAB, vol. 66, no. 2-3, pp. 155-61. https://doi.org/10.1159/000381834

APA

Koopmann, A., Bez, J., Lemenager, T., Hermann, D., Dinter, C., Reinhard, I., Hoffmann, H., Wiedemann, K., Winterer, G., & Kiefer, F. (2015). Effects of Cigarette Smoking on Plasma Concentration of the Appetite-Regulating Peptide Ghrelin. ANN NUTR METAB, 66(2-3), 155-61. https://doi.org/10.1159/000381834

Vancouver

Koopmann A, Bez J, Lemenager T, Hermann D, Dinter C, Reinhard I et al. Effects of Cigarette Smoking on Plasma Concentration of the Appetite-Regulating Peptide Ghrelin. ANN NUTR METAB. 2015;66(2-3):155-61. https://doi.org/10.1159/000381834

Bibtex

@article{a3997f97fb464b42952b56f1fcbb12d1,
title = "Effects of Cigarette Smoking on Plasma Concentration of the Appetite-Regulating Peptide Ghrelin",
abstract = "BACKGROUND: Weight gain is a common but only a partially understood consequence of smoking cessation. Existing data suggest modulating effects of the orexigenic peptide ghrelin on food intake. The aim of the present study was to investigate the effect of tobacco withdrawal on plasma concentration of acetylated and total ghrelin.METHODS: Fifty four normal-weighted smokers and 30 non-smoking healthy controls were enrolled in our study. Concentrations of acetylated and total ghrelin were measured in blood plasma drawn two hours after a standardized meal and three hours after the smokers smoked their last cigarette. The severity of tobacco addiction was assessed based on cotinine plasma concentration, the Fagerstr{\"o}m Test for Nicotine Dependence (FTND) and the number of cigarettes smoked per day.RESULTS: The plasma concentration of acetylated ghrelin, but not total ghrelin, was significantly higher in smokers than in non-smokers. Moreover, we found significant negative correlations between acetylated ghrelin and all measures of the severity of nicotine dependence.CONCLUSIONS: Early abstinence from tobacco smoking seems to be associated with increased plasma concentration of the orexigenic peptide acetylated ghrelin. This could be one reason for increased food craving during nicotine withdrawal and subsequent weight gain. Smokers might compensate these effects by increasing tobacco intake.",
keywords = "Acetylation, Adult, Cotinine, Female, Ghrelin, Humans, Male, Nicotine, Postprandial Period, Smoking, Substance Withdrawal Syndrome, Tobacco Use Disorder, Weight Gain, Journal Article, Research Support, Non-U.S. Gov't",
author = "Anne Koopmann and Jennifer Bez and Tagrid Lemenager and Derik Hermann and Christina Dinter and Iris Reinhard and Heiko Hoffmann and Klaus Wiedemann and Georg Winterer and Falk Kiefer",
note = "{\textcopyright} 2015 S. Karger AG, Basel.",
year = "2015",
doi = "10.1159/000381834",
language = "English",
volume = "66",
pages = "155--61",
journal = "ANN NUTR METAB",
issn = "0250-6807",
publisher = "S. Karger AG",
number = "2-3",

}

RIS

TY - JOUR

T1 - Effects of Cigarette Smoking on Plasma Concentration of the Appetite-Regulating Peptide Ghrelin

AU - Koopmann, Anne

AU - Bez, Jennifer

AU - Lemenager, Tagrid

AU - Hermann, Derik

AU - Dinter, Christina

AU - Reinhard, Iris

AU - Hoffmann, Heiko

AU - Wiedemann, Klaus

AU - Winterer, Georg

AU - Kiefer, Falk

N1 - © 2015 S. Karger AG, Basel.

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Weight gain is a common but only a partially understood consequence of smoking cessation. Existing data suggest modulating effects of the orexigenic peptide ghrelin on food intake. The aim of the present study was to investigate the effect of tobacco withdrawal on plasma concentration of acetylated and total ghrelin.METHODS: Fifty four normal-weighted smokers and 30 non-smoking healthy controls were enrolled in our study. Concentrations of acetylated and total ghrelin were measured in blood plasma drawn two hours after a standardized meal and three hours after the smokers smoked their last cigarette. The severity of tobacco addiction was assessed based on cotinine plasma concentration, the Fagerström Test for Nicotine Dependence (FTND) and the number of cigarettes smoked per day.RESULTS: The plasma concentration of acetylated ghrelin, but not total ghrelin, was significantly higher in smokers than in non-smokers. Moreover, we found significant negative correlations between acetylated ghrelin and all measures of the severity of nicotine dependence.CONCLUSIONS: Early abstinence from tobacco smoking seems to be associated with increased plasma concentration of the orexigenic peptide acetylated ghrelin. This could be one reason for increased food craving during nicotine withdrawal and subsequent weight gain. Smokers might compensate these effects by increasing tobacco intake.

AB - BACKGROUND: Weight gain is a common but only a partially understood consequence of smoking cessation. Existing data suggest modulating effects of the orexigenic peptide ghrelin on food intake. The aim of the present study was to investigate the effect of tobacco withdrawal on plasma concentration of acetylated and total ghrelin.METHODS: Fifty four normal-weighted smokers and 30 non-smoking healthy controls were enrolled in our study. Concentrations of acetylated and total ghrelin were measured in blood plasma drawn two hours after a standardized meal and three hours after the smokers smoked their last cigarette. The severity of tobacco addiction was assessed based on cotinine plasma concentration, the Fagerström Test for Nicotine Dependence (FTND) and the number of cigarettes smoked per day.RESULTS: The plasma concentration of acetylated ghrelin, but not total ghrelin, was significantly higher in smokers than in non-smokers. Moreover, we found significant negative correlations between acetylated ghrelin and all measures of the severity of nicotine dependence.CONCLUSIONS: Early abstinence from tobacco smoking seems to be associated with increased plasma concentration of the orexigenic peptide acetylated ghrelin. This could be one reason for increased food craving during nicotine withdrawal and subsequent weight gain. Smokers might compensate these effects by increasing tobacco intake.

KW - Acetylation

KW - Adult

KW - Cotinine

KW - Female

KW - Ghrelin

KW - Humans

KW - Male

KW - Nicotine

KW - Postprandial Period

KW - Smoking

KW - Substance Withdrawal Syndrome

KW - Tobacco Use Disorder

KW - Weight Gain

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1159/000381834

DO - 10.1159/000381834

M3 - SCORING: Journal article

C2 - 25896493

VL - 66

SP - 155

EP - 161

JO - ANN NUTR METAB

JF - ANN NUTR METAB

SN - 0250-6807

IS - 2-3

ER -