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Effects of cardiac resynchronization therapy on left ventricular mass and wall thickness in mild heart failure patients in MADIT-CRT

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Effects of cardiac resynchronization therapy on left ventricular mass and wall thickness in mild heart failure patients in MADIT-CRT. / Kutyifa, Valentina; Solomon, Scott D; Bourgoun, Mikhail; Shah, Amil M; Pouleur, Anne-Catherine; Knappe, Dorit; McNitt, Scott; Wang, Paul J; Merkely, Bela; Pfeffer, Marc; Moss, Arthur J; Zareba, Wojciech.

In: HEART RHYTHM, Vol. 10, No. 3, 03.2013, p. 354-360.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kutyifa, V, Solomon, SD, Bourgoun, M, Shah, AM, Pouleur, A-C, Knappe, D, McNitt, S, Wang, PJ, Merkely, B, Pfeffer, M, Moss, AJ & Zareba, W 2013, 'Effects of cardiac resynchronization therapy on left ventricular mass and wall thickness in mild heart failure patients in MADIT-CRT', HEART RHYTHM, vol. 10, no. 3, pp. 354-360. https://doi.org/10.1016/j.hrthm.2012.11.007

APA

Kutyifa, V., Solomon, S. D., Bourgoun, M., Shah, A. M., Pouleur, A-C., Knappe, D., McNitt, S., Wang, P. J., Merkely, B., Pfeffer, M., Moss, A. J., & Zareba, W. (2013). Effects of cardiac resynchronization therapy on left ventricular mass and wall thickness in mild heart failure patients in MADIT-CRT. HEART RHYTHM, 10(3), 354-360. https://doi.org/10.1016/j.hrthm.2012.11.007

Vancouver

Kutyifa V, Solomon SD, Bourgoun M, Shah AM, Pouleur A-C, Knappe D et al. Effects of cardiac resynchronization therapy on left ventricular mass and wall thickness in mild heart failure patients in MADIT-CRT. HEART RHYTHM. 2013 Mar;10(3):354-360. https://doi.org/10.1016/j.hrthm.2012.11.007

Bibtex

@article{d36b844956ee454692f70dc3b789d9d0,
title = "Effects of cardiac resynchronization therapy on left ventricular mass and wall thickness in mild heart failure patients in MADIT-CRT",
abstract = "BACKGROUND: The effect of cardiac resynchronization therapy (CRT) on left ventricular wall thickness and left ventricular mass (LVM) is unknown.OBJECTIVES: To evaluate the effects of CRT on septal and posterior wall thickness (SWT and PWT) and LVM in patients with left bundle branch block (LBBB) and non-LBBB vs implantable cardioverter-defibrillator patients and to assess the relationship between CRT-induced changes and cardiac events.METHODS: We investigated 843 patients with LBBB and 366 patients with non-LBBB enrolled in the Multicenter Automatic Defibrillator Implantation Trial - Cardiac Resynchronization Therapy (MADIT-CRT) trial to analyze changes in SWT, PWT, and LVM at 12 months and subsequent outcome. The primary end point was heart failure or death; secondary end points included ventricular tachycardia, ventricular fibrillation, or death.RESULTS: In LBBB patients, reduction in SWT, PWT, and LVM was more pronounced in CRT defibrillator (CRT-D) than in implantable cardioverter-defibrillator (SWT:-6.7% ± 4.4% vs-1.0% ± 1.9%; PWT:-6.4% ± 4.3% vs-0.8% ± 1.9%; LVM:-23.6% ± 9.9% vs-5.1% ± 5.1%; P<.001 for all). In CRT-D patients with non-LBBB, LVM reduction was less pronounced; however, changes in SWT and PWT were comparable. Changes in LVM correlated with changes in left ventricular end-diastolic volume. In CRT-D patients with LBBB, reduction in SWT and LVM was associated with reduction in heart failure/death (SWT: hazard ratio 0.94; 95% confidence interval 0.89-0.99 per percent change; P = .03) and ventricular tachycardia/ventricular fibrillation/death (SWT: hazard ratio 0.95; 95% confidence interval 0.91-1.00; P = .04). CRT-D patients with non-LBBB did not show favorable reduction in clinical or arrhythmic end points related to changes in SWT, PWT, or LVM.CONCLUSIONS: CRT-D was associated with significant reduction in SWT, PWT, and LVM in patients with LBBB along with left ventricular volume changes and associated favorable clinical and arrhythmia outcomes.",
keywords = "Cardiac Resynchronization Therapy/methods, Cardiac Volume, Electrocardiography, Female, Follow-Up Studies, Heart Failure/diagnostic imaging, Heart Septum/diagnostic imaging, Heart Ventricles/diagnostic imaging, Humans, Male, Middle Aged, Stroke Volume, Treatment Outcome, Ultrasonography",
author = "Valentina Kutyifa and Solomon, {Scott D} and Mikhail Bourgoun and Shah, {Amil M} and Anne-Catherine Pouleur and Dorit Knappe and Scott McNitt and Wang, {Paul J} and Bela Merkely and Marc Pfeffer and Moss, {Arthur J} and Wojciech Zareba",
note = "Published by Elsevier Inc.",
year = "2013",
month = mar,
doi = "10.1016/j.hrthm.2012.11.007",
language = "English",
volume = "10",
pages = "354--360",
journal = "HEART RHYTHM",
issn = "1547-5271",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Effects of cardiac resynchronization therapy on left ventricular mass and wall thickness in mild heart failure patients in MADIT-CRT

AU - Kutyifa, Valentina

AU - Solomon, Scott D

AU - Bourgoun, Mikhail

AU - Shah, Amil M

AU - Pouleur, Anne-Catherine

AU - Knappe, Dorit

AU - McNitt, Scott

AU - Wang, Paul J

AU - Merkely, Bela

AU - Pfeffer, Marc

AU - Moss, Arthur J

AU - Zareba, Wojciech

N1 - Published by Elsevier Inc.

PY - 2013/3

Y1 - 2013/3

N2 - BACKGROUND: The effect of cardiac resynchronization therapy (CRT) on left ventricular wall thickness and left ventricular mass (LVM) is unknown.OBJECTIVES: To evaluate the effects of CRT on septal and posterior wall thickness (SWT and PWT) and LVM in patients with left bundle branch block (LBBB) and non-LBBB vs implantable cardioverter-defibrillator patients and to assess the relationship between CRT-induced changes and cardiac events.METHODS: We investigated 843 patients with LBBB and 366 patients with non-LBBB enrolled in the Multicenter Automatic Defibrillator Implantation Trial - Cardiac Resynchronization Therapy (MADIT-CRT) trial to analyze changes in SWT, PWT, and LVM at 12 months and subsequent outcome. The primary end point was heart failure or death; secondary end points included ventricular tachycardia, ventricular fibrillation, or death.RESULTS: In LBBB patients, reduction in SWT, PWT, and LVM was more pronounced in CRT defibrillator (CRT-D) than in implantable cardioverter-defibrillator (SWT:-6.7% ± 4.4% vs-1.0% ± 1.9%; PWT:-6.4% ± 4.3% vs-0.8% ± 1.9%; LVM:-23.6% ± 9.9% vs-5.1% ± 5.1%; P<.001 for all). In CRT-D patients with non-LBBB, LVM reduction was less pronounced; however, changes in SWT and PWT were comparable. Changes in LVM correlated with changes in left ventricular end-diastolic volume. In CRT-D patients with LBBB, reduction in SWT and LVM was associated with reduction in heart failure/death (SWT: hazard ratio 0.94; 95% confidence interval 0.89-0.99 per percent change; P = .03) and ventricular tachycardia/ventricular fibrillation/death (SWT: hazard ratio 0.95; 95% confidence interval 0.91-1.00; P = .04). CRT-D patients with non-LBBB did not show favorable reduction in clinical or arrhythmic end points related to changes in SWT, PWT, or LVM.CONCLUSIONS: CRT-D was associated with significant reduction in SWT, PWT, and LVM in patients with LBBB along with left ventricular volume changes and associated favorable clinical and arrhythmia outcomes.

AB - BACKGROUND: The effect of cardiac resynchronization therapy (CRT) on left ventricular wall thickness and left ventricular mass (LVM) is unknown.OBJECTIVES: To evaluate the effects of CRT on septal and posterior wall thickness (SWT and PWT) and LVM in patients with left bundle branch block (LBBB) and non-LBBB vs implantable cardioverter-defibrillator patients and to assess the relationship between CRT-induced changes and cardiac events.METHODS: We investigated 843 patients with LBBB and 366 patients with non-LBBB enrolled in the Multicenter Automatic Defibrillator Implantation Trial - Cardiac Resynchronization Therapy (MADIT-CRT) trial to analyze changes in SWT, PWT, and LVM at 12 months and subsequent outcome. The primary end point was heart failure or death; secondary end points included ventricular tachycardia, ventricular fibrillation, or death.RESULTS: In LBBB patients, reduction in SWT, PWT, and LVM was more pronounced in CRT defibrillator (CRT-D) than in implantable cardioverter-defibrillator (SWT:-6.7% ± 4.4% vs-1.0% ± 1.9%; PWT:-6.4% ± 4.3% vs-0.8% ± 1.9%; LVM:-23.6% ± 9.9% vs-5.1% ± 5.1%; P<.001 for all). In CRT-D patients with non-LBBB, LVM reduction was less pronounced; however, changes in SWT and PWT were comparable. Changes in LVM correlated with changes in left ventricular end-diastolic volume. In CRT-D patients with LBBB, reduction in SWT and LVM was associated with reduction in heart failure/death (SWT: hazard ratio 0.94; 95% confidence interval 0.89-0.99 per percent change; P = .03) and ventricular tachycardia/ventricular fibrillation/death (SWT: hazard ratio 0.95; 95% confidence interval 0.91-1.00; P = .04). CRT-D patients with non-LBBB did not show favorable reduction in clinical or arrhythmic end points related to changes in SWT, PWT, or LVM.CONCLUSIONS: CRT-D was associated with significant reduction in SWT, PWT, and LVM in patients with LBBB along with left ventricular volume changes and associated favorable clinical and arrhythmia outcomes.

KW - Cardiac Resynchronization Therapy/methods

KW - Cardiac Volume

KW - Electrocardiography

KW - Female

KW - Follow-Up Studies

KW - Heart Failure/diagnostic imaging

KW - Heart Septum/diagnostic imaging

KW - Heart Ventricles/diagnostic imaging

KW - Humans

KW - Male

KW - Middle Aged

KW - Stroke Volume

KW - Treatment Outcome

KW - Ultrasonography

U2 - 10.1016/j.hrthm.2012.11.007

DO - 10.1016/j.hrthm.2012.11.007

M3 - SCORING: Journal article

C2 - 23174486

VL - 10

SP - 354

EP - 360

JO - HEART RHYTHM

JF - HEART RHYTHM

SN - 1547-5271

IS - 3

ER -