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Effects of age and sex on the concentrations of glutamate and glutamine in the human brain

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Effects of age and sex on the concentrations of glutamate and glutamine in the human brain. / Hädel, Sven; Wirth, Christoph; Rapp, Michael; Gallinat, Jürgen; Schubert, Florian.

In: J MAGN RESON IMAGING, Vol. 38, No. 6, 01.12.2013, p. 1480-7.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hädel, S, Wirth, C, Rapp, M, Gallinat, J & Schubert, F 2013, 'Effects of age and sex on the concentrations of glutamate and glutamine in the human brain', J MAGN RESON IMAGING, vol. 38, no. 6, pp. 1480-7. https://doi.org/10.1002/jmri.24123

APA

Hädel, S., Wirth, C., Rapp, M., Gallinat, J., & Schubert, F. (2013). Effects of age and sex on the concentrations of glutamate and glutamine in the human brain. J MAGN RESON IMAGING, 38(6), 1480-7. https://doi.org/10.1002/jmri.24123

Vancouver

Hädel S, Wirth C, Rapp M, Gallinat J, Schubert F. Effects of age and sex on the concentrations of glutamate and glutamine in the human brain. J MAGN RESON IMAGING. 2013 Dec 1;38(6):1480-7. https://doi.org/10.1002/jmri.24123

Bibtex

@article{20aff5d9d1804be697ae7a5f42cbe89a,
title = "Effects of age and sex on the concentrations of glutamate and glutamine in the human brain",
abstract = "PURPOSE: To determine the effects of age and sex on cerebral glutamate and glutamine concentrations in a large sample of healthy humans using a dedicated measuring and evaluation procedure. Exploratory examinations of other brain metabolites were also conducted.MATERIALS AND METHODS: In 118 healthy subjects aged 19 to 55 years (59 female) absolute concentrations of glutamate, glutamine, N-acetylaspartate (NAA), total creatine, and total choline (tCho) in voxels comprising the left hippocampus (HC) and the anterior cingulate cortex (ACC) were investigated using point-resolved spectroscopy with an echo time of 80 ms at 3 Tesla in combination with a reliable quantification procedure. Special care was taken to correct for multiple comparisons.RESULTS: An age-related decline of the concentrations of glutamate in both regions studied was observed whereas glutamine levels in ACC increased with age. Statistically significant sex-related differences were detected for glutamate in the HC and for tCho in the ACC. NAA decreased with age in both regions, the significance not surviving Bonferroni correction.CONCLUSION: The results demonstrate effects of age and gender on glutamate, glutamine, choline containing compounds, and NAA in healthy human brain. They add to the growing evidence for gender-specific differences in cerebral neurotransmission, metabolism, and structure across the lifespan.",
keywords = "Adult, Aging, Aspartic Acid, Choline, Female, Glutamic Acid, Glutamine, Gyrus Cinguli, Hippocampus, Humans, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Male, Neurotransmitter Agents, Reproducibility of Results, Sensitivity and Specificity, Sex Factors, Young Adult",
author = "Sven H{\"a}del and Christoph Wirth and Michael Rapp and J{\"u}rgen Gallinat and Florian Schubert",
note = "Copyright {\textcopyright} 2013 Wiley Periodicals, Inc.",
year = "2013",
month = dec,
day = "1",
doi = "10.1002/jmri.24123",
language = "English",
volume = "38",
pages = "1480--7",
journal = "J MAGN RESON IMAGING",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Effects of age and sex on the concentrations of glutamate and glutamine in the human brain

AU - Hädel, Sven

AU - Wirth, Christoph

AU - Rapp, Michael

AU - Gallinat, Jürgen

AU - Schubert, Florian

N1 - Copyright © 2013 Wiley Periodicals, Inc.

PY - 2013/12/1

Y1 - 2013/12/1

N2 - PURPOSE: To determine the effects of age and sex on cerebral glutamate and glutamine concentrations in a large sample of healthy humans using a dedicated measuring and evaluation procedure. Exploratory examinations of other brain metabolites were also conducted.MATERIALS AND METHODS: In 118 healthy subjects aged 19 to 55 years (59 female) absolute concentrations of glutamate, glutamine, N-acetylaspartate (NAA), total creatine, and total choline (tCho) in voxels comprising the left hippocampus (HC) and the anterior cingulate cortex (ACC) were investigated using point-resolved spectroscopy with an echo time of 80 ms at 3 Tesla in combination with a reliable quantification procedure. Special care was taken to correct for multiple comparisons.RESULTS: An age-related decline of the concentrations of glutamate in both regions studied was observed whereas glutamine levels in ACC increased with age. Statistically significant sex-related differences were detected for glutamate in the HC and for tCho in the ACC. NAA decreased with age in both regions, the significance not surviving Bonferroni correction.CONCLUSION: The results demonstrate effects of age and gender on glutamate, glutamine, choline containing compounds, and NAA in healthy human brain. They add to the growing evidence for gender-specific differences in cerebral neurotransmission, metabolism, and structure across the lifespan.

AB - PURPOSE: To determine the effects of age and sex on cerebral glutamate and glutamine concentrations in a large sample of healthy humans using a dedicated measuring and evaluation procedure. Exploratory examinations of other brain metabolites were also conducted.MATERIALS AND METHODS: In 118 healthy subjects aged 19 to 55 years (59 female) absolute concentrations of glutamate, glutamine, N-acetylaspartate (NAA), total creatine, and total choline (tCho) in voxels comprising the left hippocampus (HC) and the anterior cingulate cortex (ACC) were investigated using point-resolved spectroscopy with an echo time of 80 ms at 3 Tesla in combination with a reliable quantification procedure. Special care was taken to correct for multiple comparisons.RESULTS: An age-related decline of the concentrations of glutamate in both regions studied was observed whereas glutamine levels in ACC increased with age. Statistically significant sex-related differences were detected for glutamate in the HC and for tCho in the ACC. NAA decreased with age in both regions, the significance not surviving Bonferroni correction.CONCLUSION: The results demonstrate effects of age and gender on glutamate, glutamine, choline containing compounds, and NAA in healthy human brain. They add to the growing evidence for gender-specific differences in cerebral neurotransmission, metabolism, and structure across the lifespan.

KW - Adult

KW - Aging

KW - Aspartic Acid

KW - Choline

KW - Female

KW - Glutamic Acid

KW - Glutamine

KW - Gyrus Cinguli

KW - Hippocampus

KW - Humans

KW - Magnetic Resonance Imaging

KW - Magnetic Resonance Spectroscopy

KW - Male

KW - Neurotransmitter Agents

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Sex Factors

KW - Young Adult

U2 - 10.1002/jmri.24123

DO - 10.1002/jmri.24123

M3 - SCORING: Journal article

C2 - 23564615

VL - 38

SP - 1480

EP - 1487

JO - J MAGN RESON IMAGING

JF - J MAGN RESON IMAGING

SN - 1053-1807

IS - 6

ER -