Effects of acute hydrocortisone administration on declarative memory in patients with major depressive disorder: a placebo-controlled, double-blind crossover study.
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Effects of acute hydrocortisone administration on declarative memory in patients with major depressive disorder: a placebo-controlled, double-blind crossover study. / Terfehr, Kirsten; Wolf, Oliver Tobias; Schlosser, Nicole; Fernando, Silvia Carvalho; Otte, Christian; Muhtz, Christoph; Beblo, Thomas; Driessen, Martin; Spitzer, Carsten; Löwe, Bernd; Wingenfeld, Katja.
In: J CLIN PSYCHIAT, Vol. 72, No. 12, 12, 2011, p. 1644-1650.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of acute hydrocortisone administration on declarative memory in patients with major depressive disorder: a placebo-controlled, double-blind crossover study.
AU - Terfehr, Kirsten
AU - Wolf, Oliver Tobias
AU - Schlosser, Nicole
AU - Fernando, Silvia Carvalho
AU - Otte, Christian
AU - Muhtz, Christoph
AU - Beblo, Thomas
AU - Driessen, Martin
AU - Spitzer, Carsten
AU - Löwe, Bernd
AU - Wingenfeld, Katja
PY - 2011
Y1 - 2011
N2 - Major depressive disorder (MDD) has been associated with hypercortisolism, reduced glucocorticoid feedback sensitivity, and impaired memory function. In healthy subjects, administration of hydrocortisone impairs declarative memory. The aim of this study was to examine the effects of acute hydrocortisone administration on memory retrieval in MDD patients and healthy controls. We further tested whether the enhancing or impairing effects of hydrocortisone would prevail when it was given after encoding and when delayed retrieval was tested at a time point when glucocorticoid levels were still elevated.
AB - Major depressive disorder (MDD) has been associated with hypercortisolism, reduced glucocorticoid feedback sensitivity, and impaired memory function. In healthy subjects, administration of hydrocortisone impairs declarative memory. The aim of this study was to examine the effects of acute hydrocortisone administration on memory retrieval in MDD patients and healthy controls. We further tested whether the enhancing or impairing effects of hydrocortisone would prevail when it was given after encoding and when delayed retrieval was tested at a time point when glucocorticoid levels were still elevated.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Double-Blind Method
KW - Placebos
KW - Anti-Inflammatory Agents/administration & dosage/adverse effects
KW - Cross-Over Studies
KW - Depressive Disorder, Major/drug therapy/psychology
KW - Hydrocortisone/administration & dosage/adverse effects
KW - Learning/drug effects
KW - Memory/drug effects
KW - Mental Recall/drug effects
KW - Wechsler Scales
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Double-Blind Method
KW - Placebos
KW - Anti-Inflammatory Agents/administration & dosage/adverse effects
KW - Cross-Over Studies
KW - Depressive Disorder, Major/drug therapy/psychology
KW - Hydrocortisone/administration & dosage/adverse effects
KW - Learning/drug effects
KW - Memory/drug effects
KW - Mental Recall/drug effects
KW - Wechsler Scales
M3 - SCORING: Journal article
VL - 72
SP - 1644
EP - 1650
JO - J CLIN PSYCHIAT
JF - J CLIN PSYCHIAT
SN - 0160-6689
IS - 12
M1 - 12
ER -