Research ExplorerPublicationsEffects of a Psychological Internet Intervention in the Trea...

Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial

Standard

Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial. / Klein, Jan Philipp; Berger, Thomas; Schröder, Johanna; Späth, Christina; Meyer, Björn; Caspar, Franz; Lutz, Wolfgang; Arndt, Alice; Greiner, Wolfgang; Gräfe, Viola; Hautzinger, Martin; Fuhr, Kristina; Rose, Matthias; Nolte, Sandra; Löwe, Bernd; Anderssoni, Gerhard; Vettorazzi, Eik; Moritz, Steffen; Hohagen, Fritz.

In: PSYCHOTHER PSYCHOSOM, Vol. 85, No. 4, 06.2016, p. 218-228.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Klein, JP, Berger, T, Schröder, J, Späth, C, Meyer, B, Caspar, F, Lutz, W, Arndt, A, Greiner, W, Gräfe, V, Hautzinger, M, Fuhr, K, Rose, M, Nolte, S, Löwe, B, Anderssoni, G, Vettorazzi, E, Moritz, S & Hohagen, F 2016, 'Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial', PSYCHOTHER PSYCHOSOM, vol. 85, no. 4, pp. 218-228. https://doi.org/10.1159/000445355

APA

Klein, J. P., Berger, T., Schröder, J., Späth, C., Meyer, B., Caspar, F., Lutz, W., Arndt, A., Greiner, W., Gräfe, V., Hautzinger, M., Fuhr, K., Rose, M., Nolte, S., Löwe, B., Anderssoni, G., Vettorazzi, E., Moritz, S., & Hohagen, F. (2016). Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial. PSYCHOTHER PSYCHOSOM, 85(4), 218-228. https://doi.org/10.1159/000445355

Vancouver

Klein JP, Berger T, Schröder J, Späth C, Meyer B, Caspar F et al. Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial. PSYCHOTHER PSYCHOSOM. 2016 Jun;85(4):218-228. https://doi.org/10.1159/000445355

Bibtex

@article{08904b9bc22b4e88b8a0a6e901860acd,
title = "Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial",
abstract = "BACKGROUND: Mild to moderate depressive symptoms are common but often remain unrecognized and treated inadequately. We hypothesized that an Internet intervention in addition to usual care is superior to care as usual alone (CAU) in the treatment of mild to moderate depressive symptoms in adults.METHODS: This trial was controlled, randomized and assessor-blinded. Participants with mild to moderate depressive symptoms (Patient Health Questionnaire, PHQ-9, score 5-14) were recruited from clinical and non-clinical settings and randomized to either CAU or a 12-week Internet intervention (Deprexis) adjunctive to usual care. Outcomes were assessed at baseline, 3 months (post-assessment) and 6 months (follow-up). The primary outcome measure was self-rated depression severity (PHQ-9). The main analysis was based on the intention-to-treat principle and used linear mixed models.RESULTS: A total of 1,013 participants were randomized. Changes in PHQ-9 from baseline differed signixFB01;cantly between groups (t825 = 6.12, p < 0.001 for the main effect of group). The post-assessment between-group effect size in favour of the intervention was d = 0.39 (95% CI: 0.13-0.64). It was stable at follow-up, with d = 0.32 (95% CI: 0.06-0.69). The rate of participants experiencing at least minimally clinically important PHQ-9 change at the post-assessment was higher in the intervention group (35.6 vs. 20.2%) with a number needed to treat of 7 (95% CI: 5-10).CONCLUSIONS: The Internet intervention examined in this trial was superior to CAU alone in reducing mild to moderate depressive symptoms. The magnitude of the effect is clinically important and has public health implications.",
author = "Klein, {Jan Philipp} and Thomas Berger and Johanna Schr{\"o}der and Christina Sp{\"a}th and Bj{\"o}rn Meyer and Franz Caspar and Wolfgang Lutz and Alice Arndt and Wolfgang Greiner and Viola Gr{\"a}fe and Martin Hautzinger and Kristina Fuhr and Matthias Rose and Sandra Nolte and Bernd L{\"o}we and Gerhard Anderssoni and Eik Vettorazzi and Steffen Moritz and Fritz Hohagen",
note = "{\textcopyright} 2016 S. Karger AG, Basel.",
year = "2016",
month = jun,
doi = "10.1159/000445355",
language = "English",
volume = "85",
pages = "218--228",
journal = "PSYCHOTHER PSYCHOSOM",
issn = "0033-3190",
publisher = "S. Karger AG",
number = "4",

}

RIS

TY - JOUR

T1 - Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial

AU - Klein, Jan Philipp

AU - Berger, Thomas

AU - Schröder, Johanna

AU - Späth, Christina

AU - Meyer, Björn

AU - Caspar, Franz

AU - Lutz, Wolfgang

AU - Arndt, Alice

AU - Greiner, Wolfgang

AU - Gräfe, Viola

AU - Hautzinger, Martin

AU - Fuhr, Kristina

AU - Rose, Matthias

AU - Nolte, Sandra

AU - Löwe, Bernd

AU - Anderssoni, Gerhard

AU - Vettorazzi, Eik

AU - Moritz, Steffen

AU - Hohagen, Fritz

N1 - © 2016 S. Karger AG, Basel.

PY - 2016/6

Y1 - 2016/6

N2 - BACKGROUND: Mild to moderate depressive symptoms are common but often remain unrecognized and treated inadequately. We hypothesized that an Internet intervention in addition to usual care is superior to care as usual alone (CAU) in the treatment of mild to moderate depressive symptoms in adults.METHODS: This trial was controlled, randomized and assessor-blinded. Participants with mild to moderate depressive symptoms (Patient Health Questionnaire, PHQ-9, score 5-14) were recruited from clinical and non-clinical settings and randomized to either CAU or a 12-week Internet intervention (Deprexis) adjunctive to usual care. Outcomes were assessed at baseline, 3 months (post-assessment) and 6 months (follow-up). The primary outcome measure was self-rated depression severity (PHQ-9). The main analysis was based on the intention-to-treat principle and used linear mixed models.RESULTS: A total of 1,013 participants were randomized. Changes in PHQ-9 from baseline differed signixFB01;cantly between groups (t825 = 6.12, p < 0.001 for the main effect of group). The post-assessment between-group effect size in favour of the intervention was d = 0.39 (95% CI: 0.13-0.64). It was stable at follow-up, with d = 0.32 (95% CI: 0.06-0.69). The rate of participants experiencing at least minimally clinically important PHQ-9 change at the post-assessment was higher in the intervention group (35.6 vs. 20.2%) with a number needed to treat of 7 (95% CI: 5-10).CONCLUSIONS: The Internet intervention examined in this trial was superior to CAU alone in reducing mild to moderate depressive symptoms. The magnitude of the effect is clinically important and has public health implications.

AB - BACKGROUND: Mild to moderate depressive symptoms are common but often remain unrecognized and treated inadequately. We hypothesized that an Internet intervention in addition to usual care is superior to care as usual alone (CAU) in the treatment of mild to moderate depressive symptoms in adults.METHODS: This trial was controlled, randomized and assessor-blinded. Participants with mild to moderate depressive symptoms (Patient Health Questionnaire, PHQ-9, score 5-14) were recruited from clinical and non-clinical settings and randomized to either CAU or a 12-week Internet intervention (Deprexis) adjunctive to usual care. Outcomes were assessed at baseline, 3 months (post-assessment) and 6 months (follow-up). The primary outcome measure was self-rated depression severity (PHQ-9). The main analysis was based on the intention-to-treat principle and used linear mixed models.RESULTS: A total of 1,013 participants were randomized. Changes in PHQ-9 from baseline differed signixFB01;cantly between groups (t825 = 6.12, p < 0.001 for the main effect of group). The post-assessment between-group effect size in favour of the intervention was d = 0.39 (95% CI: 0.13-0.64). It was stable at follow-up, with d = 0.32 (95% CI: 0.06-0.69). The rate of participants experiencing at least minimally clinically important PHQ-9 change at the post-assessment was higher in the intervention group (35.6 vs. 20.2%) with a number needed to treat of 7 (95% CI: 5-10).CONCLUSIONS: The Internet intervention examined in this trial was superior to CAU alone in reducing mild to moderate depressive symptoms. The magnitude of the effect is clinically important and has public health implications.

U2 - 10.1159/000445355

DO - 10.1159/000445355

M3 - SCORING: Journal article

C2 - 27230863

VL - 85

SP - 218

EP - 228

JO - PSYCHOTHER PSYCHOSOM

JF - PSYCHOTHER PSYCHOSOM

SN - 0033-3190

IS - 4

ER -