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Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection

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Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection. / Amezcua Vesely, Maria Carolina; Pallis, Paris; Bielecki, Piotr; Low, Jun Siong; Zhao, Jun; Harman, Christian C D; Kroehling, Lina; Jackson, Ruaidhrí; Bailis, Will; Licona-Limón, Paula; Xu, Hao; Iijima, Norifumi; Pillai, Padmini S; Kaplan, Daniel H; Weaver, Casey T; Kluger, Yuval; Kowalczyk, Monika S; Iwasaki, Akiko; Pereira, Joao P; Esplugues, Enric; Gagliani, Nicola; Flavell, Richard A.

In: CELL, Vol. 178, No. 5, 22.08.2019, p. 1176-1188.e15.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Amezcua Vesely, MC, Pallis, P, Bielecki, P, Low, JS, Zhao, J, Harman, CCD, Kroehling, L, Jackson, R, Bailis, W, Licona-Limón, P, Xu, H, Iijima, N, Pillai, PS, Kaplan, DH, Weaver, CT, Kluger, Y, Kowalczyk, MS, Iwasaki, A, Pereira, JP, Esplugues, E, Gagliani, N & Flavell, RA 2019, 'Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection', CELL, vol. 178, no. 5, pp. 1176-1188.e15. https://doi.org/10.1016/j.cell.2019.07.032

APA

Amezcua Vesely, M. C., Pallis, P., Bielecki, P., Low, J. S., Zhao, J., Harman, C. C. D., Kroehling, L., Jackson, R., Bailis, W., Licona-Limón, P., Xu, H., Iijima, N., Pillai, P. S., Kaplan, D. H., Weaver, C. T., Kluger, Y., Kowalczyk, M. S., Iwasaki, A., Pereira, J. P., ... Flavell, R. A. (2019). Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection. CELL, 178(5), 1176-1188.e15. https://doi.org/10.1016/j.cell.2019.07.032

Vancouver

Amezcua Vesely MC, Pallis P, Bielecki P, Low JS, Zhao J, Harman CCD et al. Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection. CELL. 2019 Aug 22;178(5):1176-1188.e15. https://doi.org/10.1016/j.cell.2019.07.032

Bibtex

@article{140c2fb1c1d1486a80b49f0e9a076ad5,
title = "Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection",
abstract = "Adaptive immunity provides life-long protection by generating central and effector memory T cells and the most recently described tissue resident memory T (TRM) cells. However, the cellular origin of CD4 TRM cells and their contribution to host defense remain elusive. Using IL-17A tracking-fate mouse models, we found that a significant fraction of lung CD4 TRM cells derive from IL-17A-producing effector (TH17) cells following immunization with heat-killed Klebsiella pneumonia (Kp). These exTH17 TRM cells are maintained in the lung by IL-7, produced by lymphatic endothelial cells. During a memory response, neither antibodies, γδ T cells, nor circulatory T cells are sufficient for the rapid host defense required to eliminate Kp. Conversely, using parabiosis and depletion studies, we demonstrated that exTH17 TRM cells play an important role in bacterial clearance. Thus, we delineate the origin and function of airway CD4 TRM cells during bacterial infection, offering novel strategies for targeted vaccine design.",
author = "{Amezcua Vesely}, {Maria Carolina} and Paris Pallis and Piotr Bielecki and Low, {Jun Siong} and Jun Zhao and Harman, {Christian C D} and Lina Kroehling and Ruaidhr{\'i} Jackson and Will Bailis and Paula Licona-Lim{\'o}n and Hao Xu and Norifumi Iijima and Pillai, {Padmini S} and Kaplan, {Daniel H} and Weaver, {Casey T} and Yuval Kluger and Kowalczyk, {Monika S} and Akiko Iwasaki and Pereira, {Joao P} and Enric Esplugues and Nicola Gagliani and Flavell, {Richard A}",
note = "Copyright {\textcopyright} 2019 Elsevier Inc. All rights reserved.",
year = "2019",
month = aug,
day = "22",
doi = "10.1016/j.cell.2019.07.032",
language = "English",
volume = "178",
pages = "1176--1188.e15",
journal = "CELL",
issn = "0092-8674",
publisher = "Cell Press",
number = "5",

}

RIS

TY - JOUR

T1 - Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection

AU - Amezcua Vesely, Maria Carolina

AU - Pallis, Paris

AU - Bielecki, Piotr

AU - Low, Jun Siong

AU - Zhao, Jun

AU - Harman, Christian C D

AU - Kroehling, Lina

AU - Jackson, Ruaidhrí

AU - Bailis, Will

AU - Licona-Limón, Paula

AU - Xu, Hao

AU - Iijima, Norifumi

AU - Pillai, Padmini S

AU - Kaplan, Daniel H

AU - Weaver, Casey T

AU - Kluger, Yuval

AU - Kowalczyk, Monika S

AU - Iwasaki, Akiko

AU - Pereira, Joao P

AU - Esplugues, Enric

AU - Gagliani, Nicola

AU - Flavell, Richard A

N1 - Copyright © 2019 Elsevier Inc. All rights reserved.

PY - 2019/8/22

Y1 - 2019/8/22

N2 - Adaptive immunity provides life-long protection by generating central and effector memory T cells and the most recently described tissue resident memory T (TRM) cells. However, the cellular origin of CD4 TRM cells and their contribution to host defense remain elusive. Using IL-17A tracking-fate mouse models, we found that a significant fraction of lung CD4 TRM cells derive from IL-17A-producing effector (TH17) cells following immunization with heat-killed Klebsiella pneumonia (Kp). These exTH17 TRM cells are maintained in the lung by IL-7, produced by lymphatic endothelial cells. During a memory response, neither antibodies, γδ T cells, nor circulatory T cells are sufficient for the rapid host defense required to eliminate Kp. Conversely, using parabiosis and depletion studies, we demonstrated that exTH17 TRM cells play an important role in bacterial clearance. Thus, we delineate the origin and function of airway CD4 TRM cells during bacterial infection, offering novel strategies for targeted vaccine design.

AB - Adaptive immunity provides life-long protection by generating central and effector memory T cells and the most recently described tissue resident memory T (TRM) cells. However, the cellular origin of CD4 TRM cells and their contribution to host defense remain elusive. Using IL-17A tracking-fate mouse models, we found that a significant fraction of lung CD4 TRM cells derive from IL-17A-producing effector (TH17) cells following immunization with heat-killed Klebsiella pneumonia (Kp). These exTH17 TRM cells are maintained in the lung by IL-7, produced by lymphatic endothelial cells. During a memory response, neither antibodies, γδ T cells, nor circulatory T cells are sufficient for the rapid host defense required to eliminate Kp. Conversely, using parabiosis and depletion studies, we demonstrated that exTH17 TRM cells play an important role in bacterial clearance. Thus, we delineate the origin and function of airway CD4 TRM cells during bacterial infection, offering novel strategies for targeted vaccine design.

U2 - 10.1016/j.cell.2019.07.032

DO - 10.1016/j.cell.2019.07.032

M3 - SCORING: Journal article

C2 - 31442406

VL - 178

SP - 1176-1188.e15

JO - CELL

JF - CELL

SN - 0092-8674

IS - 5

ER -