Effective Dynamic Range and Retest Reliability of Dark-Adapted Two-Color Fundus-Controlled Perimetry in Patients With Macular Diseases
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Effective Dynamic Range and Retest Reliability of Dark-Adapted Two-Color Fundus-Controlled Perimetry in Patients With Macular Diseases. / Pfau, Maximilian; Lindner, Moritz; Müller, Philipp L; Birtel, Johannes; Finger, Robert P; Harmening, Wolf M; Fleckenstein, Monika; Holz, Frank G; Schmitz-Valckenberg, Steffen.
In: INVEST OPHTH VIS SCI, Vol. 58, No. 6, 01.05.2017, p. BIO158-BIO167.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Effective Dynamic Range and Retest Reliability of Dark-Adapted Two-Color Fundus-Controlled Perimetry in Patients With Macular Diseases
AU - Pfau, Maximilian
AU - Lindner, Moritz
AU - Müller, Philipp L
AU - Birtel, Johannes
AU - Finger, Robert P
AU - Harmening, Wolf M
AU - Fleckenstein, Monika
AU - Holz, Frank G
AU - Schmitz-Valckenberg, Steffen
PY - 2017/5/1
Y1 - 2017/5/1
N2 - PURPOSE: To determine the effective dynamic range (EDR), retest reliability, and number of discriminable steps (DS) for mesopic and dark-adapted two-color fundus-controlled perimetry (FCP) using the S-MAIA (Scotopic-Macular Integrity Assessment) "micro-perimeter."METHODS: In this prospective cross-sectional study, each of the 52 eyes of 52 subjects with various macular diseases (mean age 62.0 ± 16.9 years; range, 19.1-90.1 years) underwent duplicate mesopic (achromatic stimuli, 400-800 nm), dark-adapted cyan (505 nm), and dark-adapted red (627 nm) FCP using a grid of 61 stimuli covering 18° of the central retina. The EDR, the number of DS, and the retest reliability for point-wise sensitivity (PWS) were analyzed. The effects of fixation stability, sensitivity, and age on retest reliability were examined using mixed-effects models.RESULTS: The EDR was 10 to 30 dB with five DS for mesopic and 4 to 17 dB with four DS for dark-adapted cyan and red testing. PWS retest reliability was good among all three types of retinal sensitivity assessments (coefficient of repeatability ±5.79, ±4.72, and ±4.77 dB, respectively) and did not depend on fixation stability or age. PWS had no effect on retest variability in dark-adapted cyan and dark-adapted red testing but had a minor effect in mesopic testing.CONCLUSIONS: Combined mesopic and dark-adapted two-color FCP allows for reliable topographic testing of cone and rod function in patients with various macular diseases with and without foveal fixation. Retest reliability is homogeneous across eccentricities and various degrees of scotoma depth, including zones at risk for disease progression. These reliability estimates can serve for the design of future clinical trials.
AB - PURPOSE: To determine the effective dynamic range (EDR), retest reliability, and number of discriminable steps (DS) for mesopic and dark-adapted two-color fundus-controlled perimetry (FCP) using the S-MAIA (Scotopic-Macular Integrity Assessment) "micro-perimeter."METHODS: In this prospective cross-sectional study, each of the 52 eyes of 52 subjects with various macular diseases (mean age 62.0 ± 16.9 years; range, 19.1-90.1 years) underwent duplicate mesopic (achromatic stimuli, 400-800 nm), dark-adapted cyan (505 nm), and dark-adapted red (627 nm) FCP using a grid of 61 stimuli covering 18° of the central retina. The EDR, the number of DS, and the retest reliability for point-wise sensitivity (PWS) were analyzed. The effects of fixation stability, sensitivity, and age on retest reliability were examined using mixed-effects models.RESULTS: The EDR was 10 to 30 dB with five DS for mesopic and 4 to 17 dB with four DS for dark-adapted cyan and red testing. PWS retest reliability was good among all three types of retinal sensitivity assessments (coefficient of repeatability ±5.79, ±4.72, and ±4.77 dB, respectively) and did not depend on fixation stability or age. PWS had no effect on retest variability in dark-adapted cyan and dark-adapted red testing but had a minor effect in mesopic testing.CONCLUSIONS: Combined mesopic and dark-adapted two-color FCP allows for reliable topographic testing of cone and rod function in patients with various macular diseases with and without foveal fixation. Retest reliability is homogeneous across eccentricities and various degrees of scotoma depth, including zones at risk for disease progression. These reliability estimates can serve for the design of future clinical trials.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Cross-Sectional Studies
KW - Dark Adaptation/physiology
KW - Female
KW - Humans
KW - Macula Lutea/physiopathology
KW - Male
KW - Mesopic Vision/physiology
KW - Middle Aged
KW - Prospective Studies
KW - Reproducibility of Results
KW - Retinal Diseases/diagnosis
KW - Visual Field Tests/methods
KW - Visual Fields/physiology
KW - Young Adult
U2 - 10.1167/iovs.17-21454
DO - 10.1167/iovs.17-21454
M3 - SCORING: Journal article
C2 - 28692722
VL - 58
SP - BIO158-BIO167
JO - INVEST OPHTH VIS SCI
JF - INVEST OPHTH VIS SCI
SN - 0146-0404
IS - 6
ER -