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Effect of pregnancy on long-term kidney function in renal transplant recipients treated with cyclosporine and with azathioprine

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Effect of pregnancy on long-term kidney function in renal transplant recipients treated with cyclosporine and with azathioprine. / Fischer, Thorsten; Neumayer, Hans-Hellmut; Fischer, Ronald; Barenbrock, Michael; Schobel, Hans P; Lattrell, Barbara C; Jacobs, Volker R; Paepke, Stefan; von Steinburg, Stephanie Pildner; Schmalfeldt, Barbara; Schneider, Karl Theo M; Budde, Klemens.

In: AM J TRANSPLANT, Vol. 5, No. 11, 11.2005, p. 2732-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fischer, T, Neumayer, H-H, Fischer, R, Barenbrock, M, Schobel, HP, Lattrell, BC, Jacobs, VR, Paepke, S, von Steinburg, SP, Schmalfeldt, B, Schneider, KTM & Budde, K 2005, 'Effect of pregnancy on long-term kidney function in renal transplant recipients treated with cyclosporine and with azathioprine', AM J TRANSPLANT, vol. 5, no. 11, pp. 2732-9. https://doi.org/10.1111/j.1600-6143.2005.01091.x

APA

Fischer, T., Neumayer, H-H., Fischer, R., Barenbrock, M., Schobel, H. P., Lattrell, B. C., Jacobs, V. R., Paepke, S., von Steinburg, S. P., Schmalfeldt, B., Schneider, K. T. M., & Budde, K. (2005). Effect of pregnancy on long-term kidney function in renal transplant recipients treated with cyclosporine and with azathioprine. AM J TRANSPLANT, 5(11), 2732-9. https://doi.org/10.1111/j.1600-6143.2005.01091.x

Vancouver

Fischer T, Neumayer H-H, Fischer R, Barenbrock M, Schobel HP, Lattrell BC et al. Effect of pregnancy on long-term kidney function in renal transplant recipients treated with cyclosporine and with azathioprine. AM J TRANSPLANT. 2005 Nov;5(11):2732-9. https://doi.org/10.1111/j.1600-6143.2005.01091.x

Bibtex

@article{19ac25276e7a4e95adad6a7205526135,
title = "Effect of pregnancy on long-term kidney function in renal transplant recipients treated with cyclosporine and with azathioprine",
abstract = "In order to investigate the effect of different immunosuppressive regimens and the time interval between transplantation and pregnancy on long-term outcome, we performed a case-control study in pregnant renal allograft recipients. Eighty-one pregnancies of kidney transplanted recipients were identified [cyclosporine (CYA): n = 40; azathioprine (AZA): n = 41]. Controls were matched with respect to important prognostic factors. Posttransplant follow-up was 91.3 +/- 5 months. Graft and patient survival were similar in both groups and there was no apparent effect of immunosuppression. A total of 28 recipients (33%) delivered within 2 years and 6 (8%) subjects within 1 year after transplantation, but these short transplantation-to-pregnancy intervals had no apparent adverse effect on long-term outcome. In contrast to AZA-treated patients, CYA-treated patients experienced an increase in serum creatinine postpartum (1.15 +/- 0.2 mg/dL vs. 1.61 +/- 0.1 mg/dL; p < 0.05). Whole blood CYA levels decreased transiently during pregnancy from 115.9 +/- 8 ng/mL to 80.7 +/- 7 ng/mL leading to a gradual increase in drug dose from 240 +/- 14 mg/day to 324 +/- 21 mg/day (p < 0.05). Following delivery, there was an increase in CYA concentrations to 173 +/- 5.4 ng/mL, requiring rapid dose tapering to baseline of 246 +/- 15 mg/day. Pregnancies in renal recipients do not affect long-term patient and graft survival, independent of the immunosuppression. No detrimental effect of short transplantation-to-pregnancy intervals on long-term graft function was detected.",
keywords = "Adult, Azathioprine, Creatinine, Cyclosporine, Female, Follow-Up Studies, Graft Survival, Humans, Immunosuppressive Agents, Kidney Function Tests, Kidney Transplantation, Pregnancy, Pregnancy Outcome, Survival Analysis",
author = "Thorsten Fischer and Hans-Hellmut Neumayer and Ronald Fischer and Michael Barenbrock and Schobel, {Hans P} and Lattrell, {Barbara C} and Jacobs, {Volker R} and Stefan Paepke and {von Steinburg}, {Stephanie Pildner} and Barbara Schmalfeldt and Schneider, {Karl Theo M} and Klemens Budde",
year = "2005",
month = nov,
doi = "10.1111/j.1600-6143.2005.01091.x",
language = "English",
volume = "5",
pages = "2732--9",
journal = "AM J TRANSPLANT",
issn = "1600-6135",
publisher = "Wiley-Blackwell",
number = "11",

}

RIS

TY - JOUR

T1 - Effect of pregnancy on long-term kidney function in renal transplant recipients treated with cyclosporine and with azathioprine

AU - Fischer, Thorsten

AU - Neumayer, Hans-Hellmut

AU - Fischer, Ronald

AU - Barenbrock, Michael

AU - Schobel, Hans P

AU - Lattrell, Barbara C

AU - Jacobs, Volker R

AU - Paepke, Stefan

AU - von Steinburg, Stephanie Pildner

AU - Schmalfeldt, Barbara

AU - Schneider, Karl Theo M

AU - Budde, Klemens

PY - 2005/11

Y1 - 2005/11

N2 - In order to investigate the effect of different immunosuppressive regimens and the time interval between transplantation and pregnancy on long-term outcome, we performed a case-control study in pregnant renal allograft recipients. Eighty-one pregnancies of kidney transplanted recipients were identified [cyclosporine (CYA): n = 40; azathioprine (AZA): n = 41]. Controls were matched with respect to important prognostic factors. Posttransplant follow-up was 91.3 +/- 5 months. Graft and patient survival were similar in both groups and there was no apparent effect of immunosuppression. A total of 28 recipients (33%) delivered within 2 years and 6 (8%) subjects within 1 year after transplantation, but these short transplantation-to-pregnancy intervals had no apparent adverse effect on long-term outcome. In contrast to AZA-treated patients, CYA-treated patients experienced an increase in serum creatinine postpartum (1.15 +/- 0.2 mg/dL vs. 1.61 +/- 0.1 mg/dL; p < 0.05). Whole blood CYA levels decreased transiently during pregnancy from 115.9 +/- 8 ng/mL to 80.7 +/- 7 ng/mL leading to a gradual increase in drug dose from 240 +/- 14 mg/day to 324 +/- 21 mg/day (p < 0.05). Following delivery, there was an increase in CYA concentrations to 173 +/- 5.4 ng/mL, requiring rapid dose tapering to baseline of 246 +/- 15 mg/day. Pregnancies in renal recipients do not affect long-term patient and graft survival, independent of the immunosuppression. No detrimental effect of short transplantation-to-pregnancy intervals on long-term graft function was detected.

AB - In order to investigate the effect of different immunosuppressive regimens and the time interval between transplantation and pregnancy on long-term outcome, we performed a case-control study in pregnant renal allograft recipients. Eighty-one pregnancies of kidney transplanted recipients were identified [cyclosporine (CYA): n = 40; azathioprine (AZA): n = 41]. Controls were matched with respect to important prognostic factors. Posttransplant follow-up was 91.3 +/- 5 months. Graft and patient survival were similar in both groups and there was no apparent effect of immunosuppression. A total of 28 recipients (33%) delivered within 2 years and 6 (8%) subjects within 1 year after transplantation, but these short transplantation-to-pregnancy intervals had no apparent adverse effect on long-term outcome. In contrast to AZA-treated patients, CYA-treated patients experienced an increase in serum creatinine postpartum (1.15 +/- 0.2 mg/dL vs. 1.61 +/- 0.1 mg/dL; p < 0.05). Whole blood CYA levels decreased transiently during pregnancy from 115.9 +/- 8 ng/mL to 80.7 +/- 7 ng/mL leading to a gradual increase in drug dose from 240 +/- 14 mg/day to 324 +/- 21 mg/day (p < 0.05). Following delivery, there was an increase in CYA concentrations to 173 +/- 5.4 ng/mL, requiring rapid dose tapering to baseline of 246 +/- 15 mg/day. Pregnancies in renal recipients do not affect long-term patient and graft survival, independent of the immunosuppression. No detrimental effect of short transplantation-to-pregnancy intervals on long-term graft function was detected.

KW - Adult

KW - Azathioprine

KW - Creatinine

KW - Cyclosporine

KW - Female

KW - Follow-Up Studies

KW - Graft Survival

KW - Humans

KW - Immunosuppressive Agents

KW - Kidney Function Tests

KW - Kidney Transplantation

KW - Pregnancy

KW - Pregnancy Outcome

KW - Survival Analysis

U2 - 10.1111/j.1600-6143.2005.01091.x

DO - 10.1111/j.1600-6143.2005.01091.x

M3 - SCORING: Journal article

C2 - 16212634

VL - 5

SP - 2732

EP - 2739

JO - AM J TRANSPLANT

JF - AM J TRANSPLANT

SN - 1600-6135

IS - 11

ER -