Effect of Postoperative Radiotherapy for Brain Metastases
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Effect of Postoperative Radiotherapy for Brain Metastases : An Analysis. / Oertel, Michael; Baehr, Andrea; Habibeh, Omar; Haverkamp, Uwe; Stummer, Walter; Eich, Hans Theodor; Trog, Daniela.
In: ONCOL RES TREAT, Vol. 42, No. 5, 2019, p. 256-262.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of Postoperative Radiotherapy for Brain Metastases
T2 - An Analysis
AU - Oertel, Michael
AU - Baehr, Andrea
AU - Habibeh, Omar
AU - Haverkamp, Uwe
AU - Stummer, Walter
AU - Eich, Hans Theodor
AU - Trog, Daniela
N1 - © 2019 S. Karger AG, Basel.
PY - 2019
Y1 - 2019
N2 - INTRODUCTION: Brain metastases (BM) have a very poor prognosis, creating a demand for effective local therapies, such as radiotherapy (RT) and neurosurgery, the combination of which is debatable. The aim of the present study was to investigate prognostic factors and to develop treatment recommendations for patients with BM.MATERIAL AND METHODS: A total of 84 patients treated between May 2011 and July 2016 were analyzed in a single-institution retrospective study.RESULTS: Overall survival (OS) was 10.3 months. Poor OS was defined by a Karnofsky performance index of ≤70% (2.9 vs. 15.8 months; p = 0.009), male gender (6.5 vs. 18.3 months; p = 0.044), and incomplete neurosurgical resection (2.5 vs. 15.8 months; p = 0.017). These factors were also shown to be significant in univariate analysis, while only radical resection remained significant in multivariate testing (p = 0.023). A direct comparison between whole-brain RT (with or without boost) and local RT illustrated a superior OS for local therapy (22.7 vs. 9.5 months; p = 0.022), especially in case of up to 3 metastases (p = 0.041). Intracranial control was 81% with a median duration of 31.6 months.CONCLUSION: Combined modality treatment of RT and neurosurgery is effective and feasible. A complete removal of all metastases is the cardinal prognostic factor.
AB - INTRODUCTION: Brain metastases (BM) have a very poor prognosis, creating a demand for effective local therapies, such as radiotherapy (RT) and neurosurgery, the combination of which is debatable. The aim of the present study was to investigate prognostic factors and to develop treatment recommendations for patients with BM.MATERIAL AND METHODS: A total of 84 patients treated between May 2011 and July 2016 were analyzed in a single-institution retrospective study.RESULTS: Overall survival (OS) was 10.3 months. Poor OS was defined by a Karnofsky performance index of ≤70% (2.9 vs. 15.8 months; p = 0.009), male gender (6.5 vs. 18.3 months; p = 0.044), and incomplete neurosurgical resection (2.5 vs. 15.8 months; p = 0.017). These factors were also shown to be significant in univariate analysis, while only radical resection remained significant in multivariate testing (p = 0.023). A direct comparison between whole-brain RT (with or without boost) and local RT illustrated a superior OS for local therapy (22.7 vs. 9.5 months; p = 0.022), especially in case of up to 3 metastases (p = 0.041). Intracranial control was 81% with a median duration of 31.6 months.CONCLUSION: Combined modality treatment of RT and neurosurgery is effective and feasible. A complete removal of all metastases is the cardinal prognostic factor.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Brain Neoplasms/radiotherapy
KW - Cranial Irradiation
KW - Female
KW - Humans
KW - Karnofsky Performance Status
KW - Male
KW - Middle Aged
KW - Prognosis
KW - Radiotherapy, Adjuvant
KW - Retrospective Studies
KW - Young Adult
U2 - 10.1159/000499323
DO - 10.1159/000499323
M3 - SCORING: Journal article
C2 - 30995671
VL - 42
SP - 256
EP - 262
JO - ONCOL RES TREAT
JF - ONCOL RES TREAT
SN - 2296-5270
IS - 5
ER -
