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Effect of plasma from essential hypertensives on tension of aortic strips

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Effect of plasma from essential hypertensives on tension of aortic strips. / Zidek, W; Bachmann, J; Schlüter, H; Witzel, H; Storkebaum, W; Sachinidis, A.

In: Clinical and experimental hypertension. Part A, Theory and practice, Vol. 12, No. 3, 1990, p. 365-81.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zidek, W, Bachmann, J, Schlüter, H, Witzel, H, Storkebaum, W & Sachinidis, A 1990, 'Effect of plasma from essential hypertensives on tension of aortic strips', Clinical and experimental hypertension. Part A, Theory and practice, vol. 12, no. 3, pp. 365-81.

APA

Zidek, W., Bachmann, J., Schlüter, H., Witzel, H., Storkebaum, W., & Sachinidis, A. (1990). Effect of plasma from essential hypertensives on tension of aortic strips. Clinical and experimental hypertension. Part A, Theory and practice, 12(3), 365-81.

Vancouver

Zidek W, Bachmann J, Schlüter H, Witzel H, Storkebaum W, Sachinidis A. Effect of plasma from essential hypertensives on tension of aortic strips. Clinical and experimental hypertension. Part A, Theory and practice. 1990;12(3):365-81.

Bibtex

@article{9c532db9f6bf445bafa409b0cd607716,
title = "Effect of plasma from essential hypertensives on tension of aortic strips",
abstract = "The effect of fractions of plasma from essential hypertensive (n = 27) and normotensive subjects (n = 26) on the tension of aortic strips (n = 27) from normotensive rats was examined. The fractions obtained from hypertensive patients had been shown to increase blood pressure, when injected intravenously in a normotensive rat. In aortic strips the hypertensive fractions elicited a transient relaxation of variable amplitude and subsequently a sustained contraction. The normotensive fractions did not alter tension of the strips significantly. In Ca2+ free medium and after addition of nifedipine hypertensive plasma fractions did not induce a contraction, whereas in Na+ free medium the contraction was not abolished. It is concluded that in the fraction of hypertensive plasma containing substances with a molecular weight in the range of 1000-1500 Da a vasopressor agent with direct actions on arterial smooth muscle is present. The substance probably acts by increasing Ca2+ influx in vascular smooth muscle.",
keywords = "Adult, Animals, Aorta, Blood Pressure, Calcium, Female, Humans, Hypertension, In Vitro Techniques, Injections, Intravenous, Male, Middle Aged, Nifedipine, Phentolamine, Rats, Rats, Inbred WKY, Reference Values, Vasoconstriction, Journal Article",
author = "W Zidek and J Bachmann and H Schl{\"u}ter and H Witzel and W Storkebaum and A Sachinidis",
year = "1990",
language = "English",
volume = "12",
pages = "365--81",
number = "3",

}

RIS

TY - JOUR

T1 - Effect of plasma from essential hypertensives on tension of aortic strips

AU - Zidek, W

AU - Bachmann, J

AU - Schlüter, H

AU - Witzel, H

AU - Storkebaum, W

AU - Sachinidis, A

PY - 1990

Y1 - 1990

N2 - The effect of fractions of plasma from essential hypertensive (n = 27) and normotensive subjects (n = 26) on the tension of aortic strips (n = 27) from normotensive rats was examined. The fractions obtained from hypertensive patients had been shown to increase blood pressure, when injected intravenously in a normotensive rat. In aortic strips the hypertensive fractions elicited a transient relaxation of variable amplitude and subsequently a sustained contraction. The normotensive fractions did not alter tension of the strips significantly. In Ca2+ free medium and after addition of nifedipine hypertensive plasma fractions did not induce a contraction, whereas in Na+ free medium the contraction was not abolished. It is concluded that in the fraction of hypertensive plasma containing substances with a molecular weight in the range of 1000-1500 Da a vasopressor agent with direct actions on arterial smooth muscle is present. The substance probably acts by increasing Ca2+ influx in vascular smooth muscle.

AB - The effect of fractions of plasma from essential hypertensive (n = 27) and normotensive subjects (n = 26) on the tension of aortic strips (n = 27) from normotensive rats was examined. The fractions obtained from hypertensive patients had been shown to increase blood pressure, when injected intravenously in a normotensive rat. In aortic strips the hypertensive fractions elicited a transient relaxation of variable amplitude and subsequently a sustained contraction. The normotensive fractions did not alter tension of the strips significantly. In Ca2+ free medium and after addition of nifedipine hypertensive plasma fractions did not induce a contraction, whereas in Na+ free medium the contraction was not abolished. It is concluded that in the fraction of hypertensive plasma containing substances with a molecular weight in the range of 1000-1500 Da a vasopressor agent with direct actions on arterial smooth muscle is present. The substance probably acts by increasing Ca2+ influx in vascular smooth muscle.

KW - Adult

KW - Animals

KW - Aorta

KW - Blood Pressure

KW - Calcium

KW - Female

KW - Humans

KW - Hypertension

KW - In Vitro Techniques

KW - Injections, Intravenous

KW - Male

KW - Middle Aged

KW - Nifedipine

KW - Phentolamine

KW - Rats

KW - Rats, Inbred WKY

KW - Reference Values

KW - Vasoconstriction

KW - Journal Article

M3 - SCORING: Journal article

C2 - 2357840

VL - 12

SP - 365

EP - 381

IS - 3

ER -