Effect of oral cholestyramine on the elimination of high-dose methotrexate.
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Effect of oral cholestyramine on the elimination of high-dose methotrexate. / Erttmann, Rudolf; Landbeck, G.
In: J CANCER RES CLIN, Vol. 110, No. 1, 1, 1985, p. 48-50.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of oral cholestyramine on the elimination of high-dose methotrexate.
AU - Erttmann, Rudolf
AU - Landbeck, G
PY - 1985
Y1 - 1985
N2 - The anion exchange resin cholestyramine binds methotrexate (MTX) effectively in vitro. The binding capacity exceeds that of activated charcoal by a factor of 5.4. On two patients undergoing high-dose MTX therapy it is also shown that cholestyramine binds MTX in vivo. This leads to an enhanced non-renal excretion of MTX. Therefore, cholestyramine may be of clinical value in patients who develop renal function impairment whilst undergoing MTX therapy.
AB - The anion exchange resin cholestyramine binds methotrexate (MTX) effectively in vitro. The binding capacity exceeds that of activated charcoal by a factor of 5.4. On two patients undergoing high-dose MTX therapy it is also shown that cholestyramine binds MTX in vivo. This leads to an enhanced non-renal excretion of MTX. Therefore, cholestyramine may be of clinical value in patients who develop renal function impairment whilst undergoing MTX therapy.
M3 - SCORING: Zeitschriftenaufsatz
VL - 110
SP - 48
EP - 50
JO - J CANCER RES CLIN
JF - J CANCER RES CLIN
SN - 0171-5216
IS - 1
M1 - 1
ER -