Effect of one-year vitamin C- and E-supplementation on cerebrospinal fluid oxidation parameters and clinical course in Alzheimer's disease.
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Effect of one-year vitamin C- and E-supplementation on cerebrospinal fluid oxidation parameters and clinical course in Alzheimer's disease. / Arlt, Sönke; Müller-Thomsen, Tomas; Beisiegel, Ulrike; Kontush, Anatol.
In: NEUROCHEM RES, Vol. 37, No. 12, 12, 2012, p. 2706-2714.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of one-year vitamin C- and E-supplementation on cerebrospinal fluid oxidation parameters and clinical course in Alzheimer's disease.
AU - Arlt, Sönke
AU - Müller-Thomsen, Tomas
AU - Beisiegel, Ulrike
AU - Kontush, Anatol
PY - 2012
Y1 - 2012
N2 - Antioxidant vitamins are being widely discussed as a therapeutic option in Alzheimer's disease (AD). We recently found that supplementation with vitamin C and E over 1 month leads to an increase of their levels in cerebrospinal fluid (CSF) and a reduction of CSF lipid peroxidation. In the present study, we followed-up the biochemical and clinical effect of vitamin C and E supplementation in an open clinical trial over 1 year. Twelve AD patients stably taking a cholinesterase inhibitor were supplemented with vitamin C (1,000 mg/day) and E (400 I.U./day), while 11 patients taking cholinergic medication only served as a control group. Cognition was assessed at baseline, after 6 months and 12 months using the Mini-Mental State Examination; a more detailed testing of cognitive function was performed at baseline and after 12 months. From eight of the vitamin-supplemented patients, CSF was taken at baseline, after 1 month and after 1 year to measure the antioxidant effect of vitamin supplementation on CSF lipids using a recently established in vitro oxidation assay. CSF antioxidant vitamins were significantly increased after 1 month and 1 year of supplementation, while in vitro oxidation of CSF lipids was significantly reduced only after 1 year of the supplementation. The clinical course of AD did not significantly differ between the vitamin and the control group. We conclude that supplementation with vitamins E and C did not have a significant effect on the course of AD over 1 year despite of a limited antioxidant effect that could be observed in CSF.
AB - Antioxidant vitamins are being widely discussed as a therapeutic option in Alzheimer's disease (AD). We recently found that supplementation with vitamin C and E over 1 month leads to an increase of their levels in cerebrospinal fluid (CSF) and a reduction of CSF lipid peroxidation. In the present study, we followed-up the biochemical and clinical effect of vitamin C and E supplementation in an open clinical trial over 1 year. Twelve AD patients stably taking a cholinesterase inhibitor were supplemented with vitamin C (1,000 mg/day) and E (400 I.U./day), while 11 patients taking cholinergic medication only served as a control group. Cognition was assessed at baseline, after 6 months and 12 months using the Mini-Mental State Examination; a more detailed testing of cognitive function was performed at baseline and after 12 months. From eight of the vitamin-supplemented patients, CSF was taken at baseline, after 1 month and after 1 year to measure the antioxidant effect of vitamin supplementation on CSF lipids using a recently established in vitro oxidation assay. CSF antioxidant vitamins were significantly increased after 1 month and 1 year of supplementation, while in vitro oxidation of CSF lipids was significantly reduced only after 1 year of the supplementation. The clinical course of AD did not significantly differ between the vitamin and the control group. We conclude that supplementation with vitamins E and C did not have a significant effect on the course of AD over 1 year despite of a limited antioxidant effect that could be observed in CSF.
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Kinetics
KW - Lipid Peroxidation
KW - Oxidation-Reduction
KW - Alzheimer Disease/cerebrospinal fluid/metabolism/physiopathology
KW - Ascorbic Acid/administration & dosage
KW - Vitamin E/administration & dosage
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Kinetics
KW - Lipid Peroxidation
KW - Oxidation-Reduction
KW - Alzheimer Disease/cerebrospinal fluid/metabolism/physiopathology
KW - Ascorbic Acid/administration & dosage
KW - Vitamin E/administration & dosage
M3 - SCORING: Journal article
VL - 37
SP - 2706
EP - 2714
JO - NEUROCHEM RES
JF - NEUROCHEM RES
SN - 0364-3190
IS - 12
M1 - 12
ER -
