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Effect of gender and ITPA polymorphisms on ribavirin-induced anemia in chronic hepatitis C patients

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Effect of gender and ITPA polymorphisms on ribavirin-induced anemia in chronic hepatitis C patients. / Scherzer, Thomas-Matthias; Stättermayer, Albert Friedrich; Stauber, Rudolf; Maieron, Andreas; Strasser, Michael; Laferl, Hermann; Schwarzer, Remy; Datz, Christian; Rutter, Karoline; Beinhardt, Sandra; Steindl-Munda, Petra; Hofer, Harald; Ferenci, Peter.

In: J HEPATOL, Vol. 59, No. 5, 01.11.2013, p. 964-71.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Scherzer, T-M, Stättermayer, AF, Stauber, R, Maieron, A, Strasser, M, Laferl, H, Schwarzer, R, Datz, C, Rutter, K, Beinhardt, S, Steindl-Munda, P, Hofer, H & Ferenci, P 2013, 'Effect of gender and ITPA polymorphisms on ribavirin-induced anemia in chronic hepatitis C patients', J HEPATOL, vol. 59, no. 5, pp. 964-71. https://doi.org/10.1016/j.jhep.2013.06.030

APA

Scherzer, T-M., Stättermayer, A. F., Stauber, R., Maieron, A., Strasser, M., Laferl, H., Schwarzer, R., Datz, C., Rutter, K., Beinhardt, S., Steindl-Munda, P., Hofer, H., & Ferenci, P. (2013). Effect of gender and ITPA polymorphisms on ribavirin-induced anemia in chronic hepatitis C patients. J HEPATOL, 59(5), 964-71. https://doi.org/10.1016/j.jhep.2013.06.030

Vancouver

Scherzer T-M, Stättermayer AF, Stauber R, Maieron A, Strasser M, Laferl H et al. Effect of gender and ITPA polymorphisms on ribavirin-induced anemia in chronic hepatitis C patients. J HEPATOL. 2013 Nov 1;59(5):964-71. https://doi.org/10.1016/j.jhep.2013.06.030

Bibtex

@article{4c8a3fc7e2fd4e5d8c70afa0aaa67560,
title = "Effect of gender and ITPA polymorphisms on ribavirin-induced anemia in chronic hepatitis C patients",
abstract = "BACKGROUND & AIMS: Single nucleotide polymorphisms (SNPs) in the inosine triphosphate pyrophosphatase (ITPA) gene protect patients from ribavirin induced anemia. To investigate other possible protective cofactors, gender differences were analyzed in patients with HCV genotype 1.METHODS: Hemoglobin levels at baseline (Hb0) and the decline after 4 weeks of treatment (HbΔ4) were analyzed in 308 chronic hepatitis C patients participating in 5 Austrian trials (n=308, age 43.9 ± 11.1, male:185, female:123, BMI 25.3 ± 3.9, no cirrhosis: n=259, liver cirrhosis: n=49). All patients were treated with 180 μg peginterferon-alpha 2a and ribavirin [1000-1200 mg/d; females: mean (95% CI) 15.8 mg/kg (15.4-16.2); males 14.3 (14.1-14.5); p<0.001]. The SNPs rs6051702, rs1127354, rs7270101 and IL28B rs12979860 were analyzed by the StepOnePlus Real time PCR System.RESULTS: 188 were major alleles homozygotes; 95 (30.8%) carried the minor allele (C) of rs6051702, 47 (15.3%) of rs1127354 (A), and 69 (22.4%) of rs7270101 (C). The overall Hb0 was 14.8 g/dl (14.6-14.9) [mean (95%CI); females 13.7 (13.5-13.9); males 15.5; 15.3-15.6; p<0.001]. The overall HbΔ4 was greater in major allele homozygotes [2.8 g/dl (2.6-3.0)] than in minor allele carriers [1.6 (1.4-1.9); p<0.001]. Irrespective of the ITPA genotypes HbΔ4 was smaller in female [2.0 (1.7-2.2)] than in male patients [2.6 (2.4-2.8); p<0.001] and among females in premenopausal [1.5 (1.3-1.8)] than in postmenopausal patients [2.7 (2.3-3.1); p<0.001].CONCLUSIONS: Irrespective of the protective effect of ITPA mutations, premenopausal females less likely develop ribavirin induced anemia.",
keywords = "Adult, Alleles, Anemia, Antiviral Agents, Drug Therapy, Combination, Female, Genotype, Hepatitis C, Chronic, Homozygote, Humans, Interferon-alpha, Logistic Models, Male, Middle Aged, Polyethylene Glycols, Polymorphism, Single Nucleotide, Premenopause, Pyrophosphatases, Recombinant Proteins, Ribavirin, Sex Factors",
author = "Thomas-Matthias Scherzer and St{\"a}ttermayer, {Albert Friedrich} and Rudolf Stauber and Andreas Maieron and Michael Strasser and Hermann Laferl and Remy Schwarzer and Christian Datz and Karoline Rutter and Sandra Beinhardt and Petra Steindl-Munda and Harald Hofer and Peter Ferenci",
note = "Copyright {\textcopyright} 2013 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.",
year = "2013",
month = nov,
day = "1",
doi = "10.1016/j.jhep.2013.06.030",
language = "English",
volume = "59",
pages = "964--71",
journal = "J HEPATOL",
issn = "0168-8278",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Effect of gender and ITPA polymorphisms on ribavirin-induced anemia in chronic hepatitis C patients

AU - Scherzer, Thomas-Matthias

AU - Stättermayer, Albert Friedrich

AU - Stauber, Rudolf

AU - Maieron, Andreas

AU - Strasser, Michael

AU - Laferl, Hermann

AU - Schwarzer, Remy

AU - Datz, Christian

AU - Rutter, Karoline

AU - Beinhardt, Sandra

AU - Steindl-Munda, Petra

AU - Hofer, Harald

AU - Ferenci, Peter

N1 - Copyright © 2013 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

PY - 2013/11/1

Y1 - 2013/11/1

N2 - BACKGROUND & AIMS: Single nucleotide polymorphisms (SNPs) in the inosine triphosphate pyrophosphatase (ITPA) gene protect patients from ribavirin induced anemia. To investigate other possible protective cofactors, gender differences were analyzed in patients with HCV genotype 1.METHODS: Hemoglobin levels at baseline (Hb0) and the decline after 4 weeks of treatment (HbΔ4) were analyzed in 308 chronic hepatitis C patients participating in 5 Austrian trials (n=308, age 43.9 ± 11.1, male:185, female:123, BMI 25.3 ± 3.9, no cirrhosis: n=259, liver cirrhosis: n=49). All patients were treated with 180 μg peginterferon-alpha 2a and ribavirin [1000-1200 mg/d; females: mean (95% CI) 15.8 mg/kg (15.4-16.2); males 14.3 (14.1-14.5); p<0.001]. The SNPs rs6051702, rs1127354, rs7270101 and IL28B rs12979860 were analyzed by the StepOnePlus Real time PCR System.RESULTS: 188 were major alleles homozygotes; 95 (30.8%) carried the minor allele (C) of rs6051702, 47 (15.3%) of rs1127354 (A), and 69 (22.4%) of rs7270101 (C). The overall Hb0 was 14.8 g/dl (14.6-14.9) [mean (95%CI); females 13.7 (13.5-13.9); males 15.5; 15.3-15.6; p<0.001]. The overall HbΔ4 was greater in major allele homozygotes [2.8 g/dl (2.6-3.0)] than in minor allele carriers [1.6 (1.4-1.9); p<0.001]. Irrespective of the ITPA genotypes HbΔ4 was smaller in female [2.0 (1.7-2.2)] than in male patients [2.6 (2.4-2.8); p<0.001] and among females in premenopausal [1.5 (1.3-1.8)] than in postmenopausal patients [2.7 (2.3-3.1); p<0.001].CONCLUSIONS: Irrespective of the protective effect of ITPA mutations, premenopausal females less likely develop ribavirin induced anemia.

AB - BACKGROUND & AIMS: Single nucleotide polymorphisms (SNPs) in the inosine triphosphate pyrophosphatase (ITPA) gene protect patients from ribavirin induced anemia. To investigate other possible protective cofactors, gender differences were analyzed in patients with HCV genotype 1.METHODS: Hemoglobin levels at baseline (Hb0) and the decline after 4 weeks of treatment (HbΔ4) were analyzed in 308 chronic hepatitis C patients participating in 5 Austrian trials (n=308, age 43.9 ± 11.1, male:185, female:123, BMI 25.3 ± 3.9, no cirrhosis: n=259, liver cirrhosis: n=49). All patients were treated with 180 μg peginterferon-alpha 2a and ribavirin [1000-1200 mg/d; females: mean (95% CI) 15.8 mg/kg (15.4-16.2); males 14.3 (14.1-14.5); p<0.001]. The SNPs rs6051702, rs1127354, rs7270101 and IL28B rs12979860 were analyzed by the StepOnePlus Real time PCR System.RESULTS: 188 were major alleles homozygotes; 95 (30.8%) carried the minor allele (C) of rs6051702, 47 (15.3%) of rs1127354 (A), and 69 (22.4%) of rs7270101 (C). The overall Hb0 was 14.8 g/dl (14.6-14.9) [mean (95%CI); females 13.7 (13.5-13.9); males 15.5; 15.3-15.6; p<0.001]. The overall HbΔ4 was greater in major allele homozygotes [2.8 g/dl (2.6-3.0)] than in minor allele carriers [1.6 (1.4-1.9); p<0.001]. Irrespective of the ITPA genotypes HbΔ4 was smaller in female [2.0 (1.7-2.2)] than in male patients [2.6 (2.4-2.8); p<0.001] and among females in premenopausal [1.5 (1.3-1.8)] than in postmenopausal patients [2.7 (2.3-3.1); p<0.001].CONCLUSIONS: Irrespective of the protective effect of ITPA mutations, premenopausal females less likely develop ribavirin induced anemia.

KW - Adult

KW - Alleles

KW - Anemia

KW - Antiviral Agents

KW - Drug Therapy, Combination

KW - Female

KW - Genotype

KW - Hepatitis C, Chronic

KW - Homozygote

KW - Humans

KW - Interferon-alpha

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Polyethylene Glycols

KW - Polymorphism, Single Nucleotide

KW - Premenopause

KW - Pyrophosphatases

KW - Recombinant Proteins

KW - Ribavirin

KW - Sex Factors

U2 - 10.1016/j.jhep.2013.06.030

DO - 10.1016/j.jhep.2013.06.030

M3 - SCORING: Journal article

C2 - 23850877

VL - 59

SP - 964

EP - 971

JO - J HEPATOL

JF - J HEPATOL

SN - 0168-8278

IS - 5

ER -