Effect of Exercise and Respiratory Training on Clinical Progression and Survival in Patients with Severe Chronic Pulmonary Hypertension.
Standard
Effect of Exercise and Respiratory Training on Clinical Progression and Survival in Patients with Severe Chronic Pulmonary Hypertension. / Grünig, Ekkehard; Ehlken, Nicola; Ghofrani, Ardeschir; Staehler, Gerd; Meyer, F Joachim; Juenger, Jana; Opitz, Christian F; Klose, Hans; Wilkens, Heinrike; Rosenkranz, Stephan; Olschewski, Horst; Halank, Michael.
In: RESPIRATION, Vol. 81, No. 5, 5, 2011, p. 394-401.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Effect of Exercise and Respiratory Training on Clinical Progression and Survival in Patients with Severe Chronic Pulmonary Hypertension.
AU - Grünig, Ekkehard
AU - Ehlken, Nicola
AU - Ghofrani, Ardeschir
AU - Staehler, Gerd
AU - Meyer, F Joachim
AU - Juenger, Jana
AU - Opitz, Christian F
AU - Klose, Hans
AU - Wilkens, Heinrike
AU - Rosenkranz, Stephan
AU - Olschewski, Horst
AU - Halank, Michael
PY - 2011
Y1 - 2011
N2 - Background: Even though specific agents for the treatment of patients with pulmonary hypertension (PH) are available, in PH patients, physical capacity and quality of life (QoL) are often restricted and survival is reduced. Objectives: This study prospectively investigated the long-term effects of respiratory and exercise training in patients with severe chronic PH regarding safety, time to clinical worsening and survival. Methods: Fifty-eight consecutive patients with severe PH on stable disease-targeted medication received exercise and respiratory training in hospital for 3 weeks and continued at home. They were prospectively followed for 24 ± 12 months. Primary endpoints were time to clinical worsening and survival. Adverse events and changes in the 6-min walking test, QoL, WHO functional class and gas exchange were secondary endpoints and were evaluated at baseline and at weeks 3 and 15. Results: All patients tolerated the exercise training well without severe adverse events. In week 15, 6-min walking test results were significantly improved compared to baseline (by 84 ± 49 m, p <0.001), as well as QoL scores, WHO functional class (from 2.9 ± 0.5 to 2.6 ± 0.6, p <0.01), peak oxygen consumption (from 12.5 ± 3.0 to 14.6 ± 3.9 ml/min/kg, p <0.001), heart rate at rest (from 75 ± 12 to 61 ± 18 beats/min, p <0.001) and maximal workload (from 65 ± 21 to 80 ± 25 W, p <0.001). Survival at 1 and 2 years was 100 and 95%, respectively. Fifteen events occurred during the follow-up. Conclusion: This study indicates that exercise and respiratory training as add-on to medical treatment may improve exercise capacity and QoL, and that they have a good long-term safety in the described setting.
AB - Background: Even though specific agents for the treatment of patients with pulmonary hypertension (PH) are available, in PH patients, physical capacity and quality of life (QoL) are often restricted and survival is reduced. Objectives: This study prospectively investigated the long-term effects of respiratory and exercise training in patients with severe chronic PH regarding safety, time to clinical worsening and survival. Methods: Fifty-eight consecutive patients with severe PH on stable disease-targeted medication received exercise and respiratory training in hospital for 3 weeks and continued at home. They were prospectively followed for 24 ± 12 months. Primary endpoints were time to clinical worsening and survival. Adverse events and changes in the 6-min walking test, QoL, WHO functional class and gas exchange were secondary endpoints and were evaluated at baseline and at weeks 3 and 15. Results: All patients tolerated the exercise training well without severe adverse events. In week 15, 6-min walking test results were significantly improved compared to baseline (by 84 ± 49 m, p <0.001), as well as QoL scores, WHO functional class (from 2.9 ± 0.5 to 2.6 ± 0.6, p <0.01), peak oxygen consumption (from 12.5 ± 3.0 to 14.6 ± 3.9 ml/min/kg, p <0.001), heart rate at rest (from 75 ± 12 to 61 ± 18 beats/min, p <0.001) and maximal workload (from 65 ± 21 to 80 ± 25 W, p <0.001). Survival at 1 and 2 years was 100 and 95%, respectively. Fifteen events occurred during the follow-up. Conclusion: This study indicates that exercise and respiratory training as add-on to medical treatment may improve exercise capacity and QoL, and that they have a good long-term safety in the described setting.
M3 - SCORING: Zeitschriftenaufsatz
VL - 81
SP - 394
EP - 401
JO - RESPIRATION
JF - RESPIRATION
SN - 0025-7931
IS - 5
M1 - 5
ER -
