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[Effect of dose rate of ruthenium 106 plaques on tumor regression in the animal model]

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[Effect of dose rate of ruthenium 106 plaques on tumor regression in the animal model]. / Guthoff, R; Kleineidam, M; Chumbley, L; Schiller, F; Beck-Bornholdt, Hans-Peter.

In: Fortschr Ophthalmol, Vol. 88, No. 6, 6, 1991, p. 648-650.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Guthoff, R, Kleineidam, M, Chumbley, L, Schiller, F & Beck-Bornholdt, H-P 1991, '[Effect of dose rate of ruthenium 106 plaques on tumor regression in the animal model]', Fortschr Ophthalmol, vol. 88, no. 6, 6, pp. 648-650. <http://www.ncbi.nlm.nih.gov/pubmed/1794784?dopt=Citation>

APA

Guthoff, R., Kleineidam, M., Chumbley, L., Schiller, F., & Beck-Bornholdt, H-P. (1991). [Effect of dose rate of ruthenium 106 plaques on tumor regression in the animal model]. Fortschr Ophthalmol, 88(6), 648-650. [6]. http://www.ncbi.nlm.nih.gov/pubmed/1794784?dopt=Citation

Vancouver

Guthoff R, Kleineidam M, Chumbley L, Schiller F, Beck-Bornholdt H-P. [Effect of dose rate of ruthenium 106 plaques on tumor regression in the animal model]. Fortschr Ophthalmol. 1991;88(6):648-650. 6.

Bibtex

@article{a295e206d08b408794e63f24c11b2935,
title = "[Effect of dose rate of ruthenium 106 plaques on tumor regression in the animal model]",
abstract = "The influence of the dose-rate of 106Ru-plaques on tumor response was investigated in an experimental tumor-host system (rhabdomyosarcome R1H of the rat). A highly significant difference in tumor response was observed between tumors treated with the identical total dose (25 Gy) but varying dose rates (1.3 Gy/h vs 6.0 Gy/h). All tumors treated with the low-dose irradiation were locally controlled, whereas only one local tumor was controlled by higher dose irradiation. These unexpected results may be explained by the short overall treatment time with high dose rates, which does not allow sufficient reoxygenation of hypoxic tumor cells. In addition to the total dose, the dose rate should be included in treatment planning for choroidal melanoma brachytherapy, and analysis of the clinical data on this topic seems to be necessary in order to develop new therapy concepts.",
author = "R Guthoff and M Kleineidam and L Chumbley and F Schiller and Hans-Peter Beck-Bornholdt",
year = "1991",
language = "Deutsch",
volume = "88",
pages = "648--650",
number = "6",

}

RIS

TY - JOUR

T1 - [Effect of dose rate of ruthenium 106 plaques on tumor regression in the animal model]

AU - Guthoff, R

AU - Kleineidam, M

AU - Chumbley, L

AU - Schiller, F

AU - Beck-Bornholdt, Hans-Peter

PY - 1991

Y1 - 1991

N2 - The influence of the dose-rate of 106Ru-plaques on tumor response was investigated in an experimental tumor-host system (rhabdomyosarcome R1H of the rat). A highly significant difference in tumor response was observed between tumors treated with the identical total dose (25 Gy) but varying dose rates (1.3 Gy/h vs 6.0 Gy/h). All tumors treated with the low-dose irradiation were locally controlled, whereas only one local tumor was controlled by higher dose irradiation. These unexpected results may be explained by the short overall treatment time with high dose rates, which does not allow sufficient reoxygenation of hypoxic tumor cells. In addition to the total dose, the dose rate should be included in treatment planning for choroidal melanoma brachytherapy, and analysis of the clinical data on this topic seems to be necessary in order to develop new therapy concepts.

AB - The influence of the dose-rate of 106Ru-plaques on tumor response was investigated in an experimental tumor-host system (rhabdomyosarcome R1H of the rat). A highly significant difference in tumor response was observed between tumors treated with the identical total dose (25 Gy) but varying dose rates (1.3 Gy/h vs 6.0 Gy/h). All tumors treated with the low-dose irradiation were locally controlled, whereas only one local tumor was controlled by higher dose irradiation. These unexpected results may be explained by the short overall treatment time with high dose rates, which does not allow sufficient reoxygenation of hypoxic tumor cells. In addition to the total dose, the dose rate should be included in treatment planning for choroidal melanoma brachytherapy, and analysis of the clinical data on this topic seems to be necessary in order to develop new therapy concepts.

M3 - SCORING: Zeitschriftenaufsatz

VL - 88

SP - 648

EP - 650

IS - 6

M1 - 6

ER -