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Effect of carboxymethylcellulose nasal packing on wound healing after functional endoscopic sinus surgery

Standard

Effect of carboxymethylcellulose nasal packing on wound healing after functional endoscopic sinus surgery. / Kastl, Konrad G; Betz, Christian S; Siedek, Vanessa; Leunig, Andreas.

In: AM J RHINOL ALLERGY, Vol. 23, No. 1, 22.04.2009, p. 80-4.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kastl, KG, Betz, CS, Siedek, V & Leunig, A 2009, 'Effect of carboxymethylcellulose nasal packing on wound healing after functional endoscopic sinus surgery', AM J RHINOL ALLERGY, vol. 23, no. 1, pp. 80-4. https://doi.org/10.2500/ajra.2009.23.3267

APA

Kastl, K. G., Betz, C. S., Siedek, V., & Leunig, A. (2009). Effect of carboxymethylcellulose nasal packing on wound healing after functional endoscopic sinus surgery. AM J RHINOL ALLERGY, 23(1), 80-4. https://doi.org/10.2500/ajra.2009.23.3267

Vancouver

Kastl KG, Betz CS, Siedek V, Leunig A. Effect of carboxymethylcellulose nasal packing on wound healing after functional endoscopic sinus surgery. AM J RHINOL ALLERGY. 2009 Apr 22;23(1):80-4. https://doi.org/10.2500/ajra.2009.23.3267

Bibtex

@article{089eb139dd5847c2bdbf2cdb1de03b23,
title = "Effect of carboxymethylcellulose nasal packing on wound healing after functional endoscopic sinus surgery",
abstract = "BACKGROUND: Functional endoscopic sinus surgery (FESS) has become the treatment of choice for patients with medically resistant chronic rhinosinusitis. Nasal packing is usually placed after the surgery to support wound healing and prevent adhesions. The purpose of this study was to investigate the effect of carboxy-methylated cellulose (CMC) nasal packing on wound healing after FESS compared with no nasal packing.METHODS: Twenty-six patients underwent bilateral FESS. The patients were randomized to receive CMC mesh or gel packing on one side and no packing on the opposite side. The patients were followed at 2, 4, and 12 weeks after surgery. Endoscopically visible CMC, crusting, mucosal integrity, synechia formation, granulation tissue formation, and adverse side effects were assessed and documented.RESULTS: No adverse side effects were observed. No significant differences were found between the CMC-packed side and the unpacked side with respect to the outcome measure of wound healing. No difference was found between two different forms of CMC in terms of wound healing. Two weeks after surgery, endoscopically visible CMC was detected in four patients of the CMC mesh group, whereas none of the patients in the CMC gel group had endoscopically visible CMC (p = 0.040).CONCLUSION: As we were unable to establish an effect, we must question the efficacy of this packing material and the necessity of its use after FESS based on the technique of the Graz University Medical School. The mesh form of CMC could be potentially useful as a vehicle for extended drug delivery owing to its longer retention time in the nose.",
keywords = "Administration, Intranasal, Bandages, Carboxymethylcellulose Sodium, Chronic Disease, Endoscopy, Equipment Design, Female, Follow-Up Studies, Gels, Humans, Male, Middle Aged, Nasal Polyps, Otorhinolaryngologic Surgical Procedures, Postoperative Care, Rhinitis, Sinusitis, Treatment Outcome, Wound Healing, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't",
author = "Kastl, {Konrad G} and Betz, {Christian S} and Vanessa Siedek and Andreas Leunig",
year = "2009",
month = apr,
day = "22",
doi = "10.2500/ajra.2009.23.3267",
language = "English",
volume = "23",
pages = "80--4",
journal = "AM J RHINOL ALLERGY",
issn = "1945-8924",
publisher = "OceanSide Publications Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Effect of carboxymethylcellulose nasal packing on wound healing after functional endoscopic sinus surgery

AU - Kastl, Konrad G

AU - Betz, Christian S

AU - Siedek, Vanessa

AU - Leunig, Andreas

PY - 2009/4/22

Y1 - 2009/4/22

N2 - BACKGROUND: Functional endoscopic sinus surgery (FESS) has become the treatment of choice for patients with medically resistant chronic rhinosinusitis. Nasal packing is usually placed after the surgery to support wound healing and prevent adhesions. The purpose of this study was to investigate the effect of carboxy-methylated cellulose (CMC) nasal packing on wound healing after FESS compared with no nasal packing.METHODS: Twenty-six patients underwent bilateral FESS. The patients were randomized to receive CMC mesh or gel packing on one side and no packing on the opposite side. The patients were followed at 2, 4, and 12 weeks after surgery. Endoscopically visible CMC, crusting, mucosal integrity, synechia formation, granulation tissue formation, and adverse side effects were assessed and documented.RESULTS: No adverse side effects were observed. No significant differences were found between the CMC-packed side and the unpacked side with respect to the outcome measure of wound healing. No difference was found between two different forms of CMC in terms of wound healing. Two weeks after surgery, endoscopically visible CMC was detected in four patients of the CMC mesh group, whereas none of the patients in the CMC gel group had endoscopically visible CMC (p = 0.040).CONCLUSION: As we were unable to establish an effect, we must question the efficacy of this packing material and the necessity of its use after FESS based on the technique of the Graz University Medical School. The mesh form of CMC could be potentially useful as a vehicle for extended drug delivery owing to its longer retention time in the nose.

AB - BACKGROUND: Functional endoscopic sinus surgery (FESS) has become the treatment of choice for patients with medically resistant chronic rhinosinusitis. Nasal packing is usually placed after the surgery to support wound healing and prevent adhesions. The purpose of this study was to investigate the effect of carboxy-methylated cellulose (CMC) nasal packing on wound healing after FESS compared with no nasal packing.METHODS: Twenty-six patients underwent bilateral FESS. The patients were randomized to receive CMC mesh or gel packing on one side and no packing on the opposite side. The patients were followed at 2, 4, and 12 weeks after surgery. Endoscopically visible CMC, crusting, mucosal integrity, synechia formation, granulation tissue formation, and adverse side effects were assessed and documented.RESULTS: No adverse side effects were observed. No significant differences were found between the CMC-packed side and the unpacked side with respect to the outcome measure of wound healing. No difference was found between two different forms of CMC in terms of wound healing. Two weeks after surgery, endoscopically visible CMC was detected in four patients of the CMC mesh group, whereas none of the patients in the CMC gel group had endoscopically visible CMC (p = 0.040).CONCLUSION: As we were unable to establish an effect, we must question the efficacy of this packing material and the necessity of its use after FESS based on the technique of the Graz University Medical School. The mesh form of CMC could be potentially useful as a vehicle for extended drug delivery owing to its longer retention time in the nose.

KW - Administration, Intranasal

KW - Bandages

KW - Carboxymethylcellulose Sodium

KW - Chronic Disease

KW - Endoscopy

KW - Equipment Design

KW - Female

KW - Follow-Up Studies

KW - Gels

KW - Humans

KW - Male

KW - Middle Aged

KW - Nasal Polyps

KW - Otorhinolaryngologic Surgical Procedures

KW - Postoperative Care

KW - Rhinitis

KW - Sinusitis

KW - Treatment Outcome

KW - Wound Healing

KW - Comparative Study

KW - Journal Article

KW - Randomized Controlled Trial

KW - Research Support, Non-U.S. Gov't

U2 - 10.2500/ajra.2009.23.3267

DO - 10.2500/ajra.2009.23.3267

M3 - SCORING: Journal article

C2 - 19379618

VL - 23

SP - 80

EP - 84

JO - AM J RHINOL ALLERGY

JF - AM J RHINOL ALLERGY

SN - 1945-8924

IS - 1

ER -