Effect of antiangiogenic therapy on slowly growing, poorly vascularized tumors in mice.
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Effect of antiangiogenic therapy on slowly growing, poorly vascularized tumors in mice. / Beecken, W D; Fernandez, A; Joussen, A M; Achilles, Eike-Gert; Flynn, E; Lo, K M; Gillies, S D; Javaherian, K; Folkman, J; Shing, Y.
In: JNCI-J NATL CANCER I, Vol. 93, No. 5, 5, 2001, p. 382-387.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of antiangiogenic therapy on slowly growing, poorly vascularized tumors in mice.
AU - Beecken, W D
AU - Fernandez, A
AU - Joussen, A M
AU - Achilles, Eike-Gert
AU - Flynn, E
AU - Lo, K M
AU - Gillies, S D
AU - Javaherian, K
AU - Folkman, J
AU - Shing, Y
PY - 2001
Y1 - 2001
N2 - BACKGROUND: Angiogenesis is essential for tumor growth and progression. Therefore, inhibition of angiogenesis is being studied as a new anticancer therapy. Because cytotoxic chemotherapy is more effective on rapidly growing tumors than on slowly growing tumors, it has been assumed that antiangiogenic therapy will also be effective only on rapidly growing, highly vascularized tumors. We compared the effects of two angiogenesis inhibitors, TNP-470 and angiostatin, on slowly growing, poorly vascularized and rapidly growing, highly vascularized human tumors in mice. METHODS: Slowly growing (RT-4) and rapidly growing (MGH-U1) human bladder carcinoma cell lines were grown in severe combined immunodeficiency mice. Established tumors were treated with one of the two angiogenesis inhibitors. Tumor volumes, vascularity, and proliferation indices were determined. The in vitro effects of TNP-470 and of angiostatin on the proliferation of RT-4 and MGH-U1 cells were also investigated. All statistical tests were two-sided. RESULTS: RT-4 and MGH-U1 tumor growth was statistically significantly inhibited by both angiogenesis inhibitors (P
AB - BACKGROUND: Angiogenesis is essential for tumor growth and progression. Therefore, inhibition of angiogenesis is being studied as a new anticancer therapy. Because cytotoxic chemotherapy is more effective on rapidly growing tumors than on slowly growing tumors, it has been assumed that antiangiogenic therapy will also be effective only on rapidly growing, highly vascularized tumors. We compared the effects of two angiogenesis inhibitors, TNP-470 and angiostatin, on slowly growing, poorly vascularized and rapidly growing, highly vascularized human tumors in mice. METHODS: Slowly growing (RT-4) and rapidly growing (MGH-U1) human bladder carcinoma cell lines were grown in severe combined immunodeficiency mice. Established tumors were treated with one of the two angiogenesis inhibitors. Tumor volumes, vascularity, and proliferation indices were determined. The in vitro effects of TNP-470 and of angiostatin on the proliferation of RT-4 and MGH-U1 cells were also investigated. All statistical tests were two-sided. RESULTS: RT-4 and MGH-U1 tumor growth was statistically significantly inhibited by both angiogenesis inhibitors (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 93
SP - 382
EP - 387
JO - JNCI-J NATL CANCER I
JF - JNCI-J NATL CANCER I
SN - 0027-8874
IS - 5
M1 - 5
ER -
