Effect of acute hyperglycaemia and diabetes mellitus with and without short-term insulin treatment on myocardial ischaemic late preconditioning in the rabbit heart in vivo.
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Effect of acute hyperglycaemia and diabetes mellitus with and without short-term insulin treatment on myocardial ischaemic late preconditioning in the rabbit heart in vivo. / Ebel, Dirk; Müllenheim, Jost; Frässdorf, Jan; Heinen, Andre; Huhn, Ragnar; Bohlen, Thomas; Ferrari, Jan; Südkamp, Hendrik; Preckel, Benedikt; Schlack, Wolfgang; Thämer, Volker.
In: PFLUG ARCH EUR J PHY, Vol. 446, No. 2, 2, 2003, p. 175-182.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of acute hyperglycaemia and diabetes mellitus with and without short-term insulin treatment on myocardial ischaemic late preconditioning in the rabbit heart in vivo.
AU - Ebel, Dirk
AU - Müllenheim, Jost
AU - Frässdorf, Jan
AU - Heinen, Andre
AU - Huhn, Ragnar
AU - Bohlen, Thomas
AU - Ferrari, Jan
AU - Südkamp, Hendrik
AU - Preckel, Benedikt
AU - Schlack, Wolfgang
AU - Thämer, Volker
PY - 2003
Y1 - 2003
N2 - Diabetes mellitus (DM) and the resulting hyperglycaemia may interfere with the cardioprotective effect of ischaemic late preconditioning (LPC). Therefore, we investigated the effect of acute hyperglycaemia (part 1) and the effect of alloxan-induced DM with or without short-term insulin treatment (part 2) on LPC. Rabbits, chronically instrumented with a coronary artery occluder, were subjected to 30 min coronary artery occlusion and 2 h reperfusion (I/R) and infarct size (IS) was assessed. In part 1, four groups were studied. Controls were not treated further. LPC induced by a 5-min period of myocardial ischaemia 24 h before I/R reduced IS from 42+/-14 (controls) to 22+/-8% of the area at risk. Hyperglycaemia (600 mg dl(-1) by dextrose infusion, H(600)) before and during the 30 min ischaemia tended to increase IS (57+/-16%, P=0.14 vs. controls) and blocked cardioprotection by LPC (H(600)+LPC, 59+/-19%, P=1.0 vs. H(600), P=0.0003 vs. LPC). In part 2, LPC reduced infarct size from 43+/-13% (control) to 23+/-10% ( P=0.003). In diabetic animals, IS was 39+/-11%, and cardioprotection by LPC could not be elicited (DM+LPC, 41+/-16%, P=0.02 vs. LPC). Short-term insulin treatment (I, 90 min before I/R, blood glucose
AB - Diabetes mellitus (DM) and the resulting hyperglycaemia may interfere with the cardioprotective effect of ischaemic late preconditioning (LPC). Therefore, we investigated the effect of acute hyperglycaemia (part 1) and the effect of alloxan-induced DM with or without short-term insulin treatment (part 2) on LPC. Rabbits, chronically instrumented with a coronary artery occluder, were subjected to 30 min coronary artery occlusion and 2 h reperfusion (I/R) and infarct size (IS) was assessed. In part 1, four groups were studied. Controls were not treated further. LPC induced by a 5-min period of myocardial ischaemia 24 h before I/R reduced IS from 42+/-14 (controls) to 22+/-8% of the area at risk. Hyperglycaemia (600 mg dl(-1) by dextrose infusion, H(600)) before and during the 30 min ischaemia tended to increase IS (57+/-16%, P=0.14 vs. controls) and blocked cardioprotection by LPC (H(600)+LPC, 59+/-19%, P=1.0 vs. H(600), P=0.0003 vs. LPC). In part 2, LPC reduced infarct size from 43+/-13% (control) to 23+/-10% ( P=0.003). In diabetic animals, IS was 39+/-11%, and cardioprotection by LPC could not be elicited (DM+LPC, 41+/-16%, P=0.02 vs. LPC). Short-term insulin treatment (I, 90 min before I/R, blood glucose
M3 - SCORING: Zeitschriftenaufsatz
VL - 446
SP - 175
EP - 182
JO - PFLUG ARCH EUR J PHY
JF - PFLUG ARCH EUR J PHY
SN - 0031-6768
IS - 2
M1 - 2
ER -
