Effect of a mirror-like illusion on activation in the precuneus assessed with functional near-infrared spectroscopy
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Effect of a mirror-like illusion on activation in the precuneus assessed with functional near-infrared spectroscopy. / Mehnert, Jan; Brunetti, Maddalena; Steinbrink, Jens; Niedeggen, Michael; Dohle, Christian.
In: J BIOMED OPT, Vol. 18, No. 6, 2013, p. 066001.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of a mirror-like illusion on activation in the precuneus assessed with functional near-infrared spectroscopy
AU - Mehnert, Jan
AU - Brunetti, Maddalena
AU - Steinbrink, Jens
AU - Niedeggen, Michael
AU - Dohle, Christian
PY - 2013
Y1 - 2013
N2 - Mirror therapy is a therapy to treat patients with pain syndromes or hemiparesis after stroke. However, the underlying neurophysiologic mechanisms are not clearly understood. In order to determine the effect of a mirror-like illusion (MIR) on brain activity using functional near-infrared spectroscopy, 20 healthy right-handed subjects were examined. A MIR was induced by a digital horizontal inversion of the subjects' filmed hand. Optodes were placed on the primary motor cortex (M1) and the occipito-parietal cortex (precuneus, PC). Regions of interest (ROI) were defined a priori based on previous results of similar studies and confirmed by the analysis of effect sizes. Analysis of variance of the ROI signal revealed a dissociated pattern: at the PC, the MIR caused a significant inversion of a hemispheric lateralization opposite to the perceived hand, independent of the moving hand. In contrast, activity in M1 showed lateralization opposite to the moving hand, but revealed no mirror effect. These findings extend our understanding on interhemispheric rivalry and indicate that a MIR is integrated into visuomotor coordination similar to normal view, irrespective of the hand that is actually performing the task.
AB - Mirror therapy is a therapy to treat patients with pain syndromes or hemiparesis after stroke. However, the underlying neurophysiologic mechanisms are not clearly understood. In order to determine the effect of a mirror-like illusion (MIR) on brain activity using functional near-infrared spectroscopy, 20 healthy right-handed subjects were examined. A MIR was induced by a digital horizontal inversion of the subjects' filmed hand. Optodes were placed on the primary motor cortex (M1) and the occipito-parietal cortex (precuneus, PC). Regions of interest (ROI) were defined a priori based on previous results of similar studies and confirmed by the analysis of effect sizes. Analysis of variance of the ROI signal revealed a dissociated pattern: at the PC, the MIR caused a significant inversion of a hemispheric lateralization opposite to the perceived hand, independent of the moving hand. In contrast, activity in M1 showed lateralization opposite to the moving hand, but revealed no mirror effect. These findings extend our understanding on interhemispheric rivalry and indicate that a MIR is integrated into visuomotor coordination similar to normal view, irrespective of the hand that is actually performing the task.
U2 - 10.1117/1.JBO.18.6.066001
DO - 10.1117/1.JBO.18.6.066001
M3 - SCORING: Journal article
C2 - 23733017
VL - 18
SP - 066001
JO - J BIOMED OPT
JF - J BIOMED OPT
SN - 1083-3668
IS - 6
ER -
