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Economic evaluation of exercise training in patients with pulmonary hypertension

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Economic evaluation of exercise training in patients with pulmonary hypertension. / Ehlken, Nicola; Verduyn, Cora; Tiede, Henning; Staehler, Gerd; Karger, Gabriele; Nechwatal, Robert; Opitz, Christian F; Klose, Hans; Wilkens, Heinrike ; Rosenkranz, Stephan; Halank, Michael; Grünig, Ekkehard.

In: LUNG, Vol. 192, No. 3, 01.06.2014, p. 359-66.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ehlken, N, Verduyn, C, Tiede, H, Staehler, G, Karger, G, Nechwatal, R, Opitz, CF, Klose, H, Wilkens, H, Rosenkranz, S, Halank, M & Grünig, E 2014, 'Economic evaluation of exercise training in patients with pulmonary hypertension', LUNG, vol. 192, no. 3, pp. 359-66. https://doi.org/10.1007/s00408-014-9558-9

APA

Ehlken, N., Verduyn, C., Tiede, H., Staehler, G., Karger, G., Nechwatal, R., Opitz, C. F., Klose, H., Wilkens, H., Rosenkranz, S., Halank, M., & Grünig, E. (2014). Economic evaluation of exercise training in patients with pulmonary hypertension. LUNG, 192(3), 359-66. https://doi.org/10.1007/s00408-014-9558-9

Vancouver

Ehlken N, Verduyn C, Tiede H, Staehler G, Karger G, Nechwatal R et al. Economic evaluation of exercise training in patients with pulmonary hypertension. LUNG. 2014 Jun 1;192(3):359-66. https://doi.org/10.1007/s00408-014-9558-9

Bibtex

@article{92c8d7ad03d74c9b887f2731b9e8e927,
title = "Economic evaluation of exercise training in patients with pulmonary hypertension",
abstract = "PURPOSE: Exercise training as an add-on to medical therapy has been shown to improve exercise capacity, quality of life, and possibly prognosis in patients with pulmonary hypertension (PH). The purpose of this study was to analyze the impact of exercise training on healthcare costs in PH.METHODS: Estimated healthcare costs have been compared between patients with severe PH under optimized medical therapy only (control group) versus patients who received exercise training as an add-on to medical therapy (training group). Cost-analysis included a cost-estimation model of costs for baseline and follow-up visits and all PH-related healthcare events that occurred within the follow-up period. Time to clinical worsening and survival were assessed by clinical records, phone, and/or control visits.RESULTS: At baseline, the training (n = 58) and control group (n = 48) did not differ in age, gender, WHO-functional class, 6-min walking distance, hemodynamic parameters, or PH-targeted medication. During a follow-up of 24 ± 12 months, the training group had significantly better survival rates at 1 and 3 years and less worsening events (death, lung transplantation, hospitalization due to PH, new PAH-targeted medication) than the control group (15 vs. 25 events, p < 0.05), which also led to lower estimated healthcare costs of 657 within a period of 2 years.CONCLUSIONS: This is the first study to investigate the cost-effectiveness of exercise training in PH. Due to less worsening events within 2 years, healthcare costs were lower in patients performing exercise training as add-on to medical therapy than in patients with medical treatment only. Further prospective, randomized studies are needed to confirm these findings.",
author = "Nicola Ehlken and Cora Verduyn and Henning Tiede and Gerd Staehler and Gabriele Karger and Robert Nechwatal and Opitz, {Christian F} and Hans Klose and Heinrike Wilkens and Stephan Rosenkranz and Michael Halank and Ekkehard Gr{\"u}nig",
year = "2014",
month = jun,
day = "1",
doi = "10.1007/s00408-014-9558-9",
language = "English",
volume = "192",
pages = "359--66",
journal = "LUNG",
issn = "0341-2040",
publisher = "Springer New York",
number = "3",

}

RIS

TY - JOUR

T1 - Economic evaluation of exercise training in patients with pulmonary hypertension

AU - Ehlken, Nicola

AU - Verduyn, Cora

AU - Tiede, Henning

AU - Staehler, Gerd

AU - Karger, Gabriele

AU - Nechwatal, Robert

AU - Opitz, Christian F

AU - Klose, Hans

AU - Wilkens, Heinrike

AU - Rosenkranz, Stephan

AU - Halank, Michael

AU - Grünig, Ekkehard

PY - 2014/6/1

Y1 - 2014/6/1

N2 - PURPOSE: Exercise training as an add-on to medical therapy has been shown to improve exercise capacity, quality of life, and possibly prognosis in patients with pulmonary hypertension (PH). The purpose of this study was to analyze the impact of exercise training on healthcare costs in PH.METHODS: Estimated healthcare costs have been compared between patients with severe PH under optimized medical therapy only (control group) versus patients who received exercise training as an add-on to medical therapy (training group). Cost-analysis included a cost-estimation model of costs for baseline and follow-up visits and all PH-related healthcare events that occurred within the follow-up period. Time to clinical worsening and survival were assessed by clinical records, phone, and/or control visits.RESULTS: At baseline, the training (n = 58) and control group (n = 48) did not differ in age, gender, WHO-functional class, 6-min walking distance, hemodynamic parameters, or PH-targeted medication. During a follow-up of 24 ± 12 months, the training group had significantly better survival rates at 1 and 3 years and less worsening events (death, lung transplantation, hospitalization due to PH, new PAH-targeted medication) than the control group (15 vs. 25 events, p < 0.05), which also led to lower estimated healthcare costs of 657 within a period of 2 years.CONCLUSIONS: This is the first study to investigate the cost-effectiveness of exercise training in PH. Due to less worsening events within 2 years, healthcare costs were lower in patients performing exercise training as add-on to medical therapy than in patients with medical treatment only. Further prospective, randomized studies are needed to confirm these findings.

AB - PURPOSE: Exercise training as an add-on to medical therapy has been shown to improve exercise capacity, quality of life, and possibly prognosis in patients with pulmonary hypertension (PH). The purpose of this study was to analyze the impact of exercise training on healthcare costs in PH.METHODS: Estimated healthcare costs have been compared between patients with severe PH under optimized medical therapy only (control group) versus patients who received exercise training as an add-on to medical therapy (training group). Cost-analysis included a cost-estimation model of costs for baseline and follow-up visits and all PH-related healthcare events that occurred within the follow-up period. Time to clinical worsening and survival were assessed by clinical records, phone, and/or control visits.RESULTS: At baseline, the training (n = 58) and control group (n = 48) did not differ in age, gender, WHO-functional class, 6-min walking distance, hemodynamic parameters, or PH-targeted medication. During a follow-up of 24 ± 12 months, the training group had significantly better survival rates at 1 and 3 years and less worsening events (death, lung transplantation, hospitalization due to PH, new PAH-targeted medication) than the control group (15 vs. 25 events, p < 0.05), which also led to lower estimated healthcare costs of 657 within a period of 2 years.CONCLUSIONS: This is the first study to investigate the cost-effectiveness of exercise training in PH. Due to less worsening events within 2 years, healthcare costs were lower in patients performing exercise training as add-on to medical therapy than in patients with medical treatment only. Further prospective, randomized studies are needed to confirm these findings.

U2 - 10.1007/s00408-014-9558-9

DO - 10.1007/s00408-014-9558-9

M3 - SCORING: Journal article

C2 - 24609926

VL - 192

SP - 359

EP - 366

JO - LUNG

JF - LUNG

SN - 0341-2040

IS - 3

ER -