E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium

Hisani N Horne; Hannah Oh; Mark E Sherman; Maya Palakal; Stephen M Hewitt; Marjanka K Schmidt; Roger L Milne; David Hardisson; Javier Benitez; Carl Blomqvist; Manjeet K Bolla; Hermann Brenner; Jenny Chang-Claude; Renata Cora; Fergus J Couch; Katarina Cuk; Peter Devilee; Douglas F Easton; Diana M Eccles; Ursula Eilber; Jaana M Hartikainen; Päivi Heikkilä; Bernd Holleczek; Maartje J Hooning; Michael Jones; Renske Keeman; Arto Mannermaa; John W M Martens; Taru A Muranen; Heli Nevanlinna; Janet E Olson; Nick Orr; Jose I A Perez; Paul D P Pharoah; Kathryn J Ruddy; Kai-Uwe Saum; Minouk J Schoemaker; Caroline Seynaeve; Reijo Sironen; Vincent T H B M Smit; Anthony J Swerdlow; Maria Tengström; Abigail S Thomas; A Mieke Timmermans; Rob A E M Tollenaar; Melissa A Troester; Christi J van Asperen; Carolien H M van Deurzen; Flora F Van Leeuwen; Laura J Van't Veer; Montserrat García-Closas; Jonine D Figueroa

doi:10.1038/s41598-018-23733-4

E-cadherin breast tumor expression, risk factors and survival

Standard

E-cadherin breast tumor expression, risk factors and survival : Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium. / Horne, Hisani N; Oh, Hannah; Sherman, Mark E; Palakal, Maya; Hewitt, Stephen M; Schmidt, Marjanka K; Milne, Roger L; Hardisson, David; Benitez, Javier; Blomqvist, Carl; Bolla, Manjeet K; Brenner, Hermann; Chang-Claude, Jenny; Cora, Renata; Couch, Fergus J; Cuk, Katarina; Devilee, Peter; Easton, Douglas F; Eccles, Diana M; Eilber, Ursula; Hartikainen, Jaana M; Heikkilä, Päivi; Holleczek, Bernd; Hooning, Maartje J; Jones, Michael; Keeman, Renske; Mannermaa, Arto; Martens, John W M; Muranen, Taru A; Nevanlinna, Heli; Olson, Janet E; Orr, Nick; Perez, Jose I A; Pharoah, Paul D P; Ruddy, Kathryn J; Saum, Kai-Uwe; Schoemaker, Minouk J; Seynaeve, Caroline; Sironen, Reijo; Smit, Vincent T H B M; Swerdlow, Anthony J; Tengström, Maria; Thomas, Abigail S; Timmermans, A Mieke; Tollenaar, Rob A E M; Troester, Melissa A; van Asperen, Christi J; van Deurzen, Carolien H M; Van Leeuwen, Flora F; Van't Veer, Laura J; García-Closas, Montserrat; Figueroa, Jonine D.

In: SCI REP-UK, Vol. 8, No. 1, 26.04.2018, p. 6574.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Horne, HN, Oh, H, Sherman, ME, Palakal, M, Hewitt, SM, Schmidt, MK, Milne, RL, Hardisson, D, Benitez, J, Blomqvist, C, Bolla, MK, Brenner, H, Chang-Claude, J, Cora, R, Couch, FJ, Cuk, K, Devilee, P, Easton, DF, Eccles, DM, Eilber, U, Hartikainen, JM, Heikkilä, P, Holleczek, B, Hooning, MJ, Jones, M, Keeman, R, Mannermaa, A, Martens, JWM, Muranen, TA, Nevanlinna, H, Olson, JE, Orr, N, Perez, JIA, Pharoah, PDP, Ruddy, KJ, Saum, K-U, Schoemaker, MJ, Seynaeve, C, Sironen, R, Smit, VTHBM, Swerdlow, AJ, Tengström, M, Thomas, AS, Timmermans, AM, Tollenaar, RAEM, Troester, MA, van Asperen, CJ, van Deurzen, CHM, Van Leeuwen, FF, Van't Veer, LJ, García-Closas, M & Figueroa, JD 2018, 'E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium', SCI REP-UK, vol. 8, no. 1, pp. 6574. https://doi.org/10.1038/s41598-018-23733-4

APA

Horne, H. N., Oh, H., Sherman, M. E., Palakal, M., Hewitt, S. M., Schmidt, M. K., Milne, R. L., Hardisson, D., Benitez, J., Blomqvist, C., Bolla, M. K., Brenner, H., Chang-Claude, J., Cora, R., Couch, F. J., Cuk, K., Devilee, P., Easton, D. F., Eccles, D. M., ... Figueroa, J. D. (2018). E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium. SCI REP-UK, 8(1), 6574. https://doi.org/10.1038/s41598-018-23733-4

Vancouver

Horne HN, Oh H, Sherman ME, Palakal M, Hewitt SM, Schmidt MK et al. E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium. SCI REP-UK. 2018 Apr 26;8(1):6574. https://doi.org/10.1038/s41598-018-23733-4

Bibtex

@article{aab58fc7e86547a7b35b8098861b39dc,

title = "E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium",

abstract = "E-cadherin (CDH1) is a putative tumor suppressor gene implicated in breast carcinogenesis. Yet, whether risk factors or survival differ by E-cadherin tumor expression is unclear. We evaluated E-cadherin tumor immunohistochemistry expression using tissue microarrays of 5,933 female invasive breast cancers from 12 studies from the Breast Cancer Consortium. H-scores were calculated and case-case odds ratios (OR) and 95% confidence intervals (CIs) were estimated using logistic regression. Survival analyses were performed using Cox regression models. All analyses were stratified by estrogen receptor (ER) status and histologic subtype. E-cadherin low cases (N = 1191, 20%) were more frequently of lobular histology, low grade, >2 cm, and HER2-negative. Loss of E-cadherin expression (score < 100) was associated with menopausal hormone use among ER-positive tumors (ever compared to never users, OR = 1.24, 95% CI = 0.97-1.59), which was stronger when we evaluated complete loss of E-cadherin (i.e. H-score = 0), OR = 1.57, 95% CI = 1.06-2.33. Breast cancer specific mortality was unrelated to E-cadherin expression in multivariable models. E-cadherin low expression is associated with lobular histology, tumor characteristics and menopausal hormone use, with no evidence of an association with breast cancer specific survival. These data support loss of E-cadherin expression as an important marker of tumor subtypes.",

keywords = "Journal Article",

author = "Horne, {Hisani N} and Hannah Oh and Sherman, {Mark E} and Maya Palakal and Hewitt, {Stephen M} and Schmidt, {Marjanka K} and Milne, {Roger L} and David Hardisson and Javier Benitez and Carl Blomqvist and Bolla, {Manjeet K} and Hermann Brenner and Jenny Chang-Claude and Renata Cora and Couch, {Fergus J} and Katarina Cuk and Peter Devilee and Easton, {Douglas F} and Eccles, {Diana M} and Ursula Eilber and Hartikainen, {Jaana M} and P{\"a}ivi Heikkil{\"a} and Bernd Holleczek and Hooning, {Maartje J} and Michael Jones and Renske Keeman and Arto Mannermaa and Martens, {John W M} and Muranen, {Taru A} and Heli Nevanlinna and Olson, {Janet E} and Nick Orr and Perez, {Jose I A} and Pharoah, {Paul D P} and Ruddy, {Kathryn J} and Kai-Uwe Saum and Schoemaker, {Minouk J} and Caroline Seynaeve and Reijo Sironen and Smit, {Vincent T H B M} and Swerdlow, {Anthony J} and Maria Tengstr{\"o}m and Thomas, {Abigail S} and Timmermans, {A Mieke} and Tollenaar, {Rob A E M} and Troester, {Melissa A} and {van Asperen}, {Christi J} and {van Deurzen}, {Carolien H M} and {Van Leeuwen}, {Flora F} and {Van't Veer}, {Laura J} and Montserrat Garc{\'i}a-Closas and Figueroa, {Jonine D}",

year = "2018",

month = apr,

day = "26",

doi = "10.1038/s41598-018-23733-4",

language = "English",

volume = "8",

pages = "6574",

journal = "SCI REP-UK",

issn = "2045-2322",

publisher = "NATURE PUBLISHING GROUP",

number = "1",

}

RIS

TY - JOUR

T1 - E-cadherin breast tumor expression, risk factors and survival

T2 - Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium

AU - Horne, Hisani N

AU - Oh, Hannah

AU - Sherman, Mark E

AU - Palakal, Maya

AU - Hewitt, Stephen M

AU - Schmidt, Marjanka K

AU - Milne, Roger L

AU - Hardisson, David

AU - Benitez, Javier

AU - Blomqvist, Carl

AU - Bolla, Manjeet K

AU - Brenner, Hermann

AU - Chang-Claude, Jenny

AU - Cora, Renata

AU - Couch, Fergus J

AU - Cuk, Katarina

AU - Devilee, Peter

AU - Easton, Douglas F

AU - Eccles, Diana M

AU - Eilber, Ursula

AU - Hartikainen, Jaana M

AU - Heikkilä, Päivi

AU - Holleczek, Bernd

AU - Hooning, Maartje J

AU - Jones, Michael

AU - Keeman, Renske

AU - Mannermaa, Arto

AU - Martens, John W M

AU - Muranen, Taru A

AU - Nevanlinna, Heli

AU - Olson, Janet E

AU - Orr, Nick

AU - Perez, Jose I A

AU - Pharoah, Paul D P

AU - Ruddy, Kathryn J

AU - Saum, Kai-Uwe

AU - Schoemaker, Minouk J

AU - Seynaeve, Caroline

AU - Sironen, Reijo

AU - Smit, Vincent T H B M

AU - Swerdlow, Anthony J

AU - Tengström, Maria

AU - Thomas, Abigail S

AU - Timmermans, A Mieke

AU - Tollenaar, Rob A E M

AU - Troester, Melissa A

AU - van Asperen, Christi J

AU - van Deurzen, Carolien H M

AU - Van Leeuwen, Flora F

AU - Van't Veer, Laura J

AU - García-Closas, Montserrat

AU - Figueroa, Jonine D

PY - 2018/4/26

Y1 - 2018/4/26

N2 - E-cadherin (CDH1) is a putative tumor suppressor gene implicated in breast carcinogenesis. Yet, whether risk factors or survival differ by E-cadherin tumor expression is unclear. We evaluated E-cadherin tumor immunohistochemistry expression using tissue microarrays of 5,933 female invasive breast cancers from 12 studies from the Breast Cancer Consortium. H-scores were calculated and case-case odds ratios (OR) and 95% confidence intervals (CIs) were estimated using logistic regression. Survival analyses were performed using Cox regression models. All analyses were stratified by estrogen receptor (ER) status and histologic subtype. E-cadherin low cases (N = 1191, 20%) were more frequently of lobular histology, low grade, >2 cm, and HER2-negative. Loss of E-cadherin expression (score < 100) was associated with menopausal hormone use among ER-positive tumors (ever compared to never users, OR = 1.24, 95% CI = 0.97-1.59), which was stronger when we evaluated complete loss of E-cadherin (i.e. H-score = 0), OR = 1.57, 95% CI = 1.06-2.33. Breast cancer specific mortality was unrelated to E-cadherin expression in multivariable models. E-cadherin low expression is associated with lobular histology, tumor characteristics and menopausal hormone use, with no evidence of an association with breast cancer specific survival. These data support loss of E-cadherin expression as an important marker of tumor subtypes.

AB - E-cadherin (CDH1) is a putative tumor suppressor gene implicated in breast carcinogenesis. Yet, whether risk factors or survival differ by E-cadherin tumor expression is unclear. We evaluated E-cadherin tumor immunohistochemistry expression using tissue microarrays of 5,933 female invasive breast cancers from 12 studies from the Breast Cancer Consortium. H-scores were calculated and case-case odds ratios (OR) and 95% confidence intervals (CIs) were estimated using logistic regression. Survival analyses were performed using Cox regression models. All analyses were stratified by estrogen receptor (ER) status and histologic subtype. E-cadherin low cases (N = 1191, 20%) were more frequently of lobular histology, low grade, >2 cm, and HER2-negative. Loss of E-cadherin expression (score < 100) was associated with menopausal hormone use among ER-positive tumors (ever compared to never users, OR = 1.24, 95% CI = 0.97-1.59), which was stronger when we evaluated complete loss of E-cadherin (i.e. H-score = 0), OR = 1.57, 95% CI = 1.06-2.33. Breast cancer specific mortality was unrelated to E-cadherin expression in multivariable models. E-cadherin low expression is associated with lobular histology, tumor characteristics and menopausal hormone use, with no evidence of an association with breast cancer specific survival. These data support loss of E-cadherin expression as an important marker of tumor subtypes.

KW - Journal Article

U2 - 10.1038/s41598-018-23733-4

DO - 10.1038/s41598-018-23733-4

M3 - SCORING: Journal article

C2 - 29700408

VL - 8

SP - 6574

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

ER -