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Early Versus Standard Care Invasive Examination and Treatment of Patients With Non-ST-Segment Elevation Acute Coronary Syndrome

Standard

Early Versus Standard Care Invasive Examination and Treatment of Patients With Non-ST-Segment Elevation Acute Coronary Syndrome. / Kofoed, Klaus F; Kelbæk, Henning; Hansen, Peter Riis; Torp-Pedersen, Christian; Høfsten, Dan; Kløvgaard, Lene; Holmvang, Lene; Helqvist, Steffen; Jørgensen, Erik; Galatius, Søren; Pedersen, Frants; Bang, Lia; Saunamaki, Kari; Clemmensen, Peter; Linde, Jesper J; Heitmann, Merete; Wendelboe Nielsen, Olav; Raymond, Ilan E; Kristiansen, Ole Peter; Svendsen, Ida Hastrup; Bech, Jan; Dominguez Vall-Lamora, Maria Helena; Kragelund, Charlotte; Hansen, Thomas Fritz; Dahlgaard Hove, Jens; Jørgensen, Tem; Fornitz, Gitte G; Steffensen, Rolf; Jurlander, Birgit; Abdulla, Jawdat; Lyngbæk, Stig; Elming, Hanne; Therkelsen, Susette Krohn; Abildgaard, Ulrik; Jensen, Jan Skov; Gislason, Gunnar; Køber, Lars V; Engstrøm, Thomas.

In: CIRCULATION, Vol. 138, No. 24, 11.12.2018, p. 2741-2750.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kofoed, KF, Kelbæk, H, Hansen, PR, Torp-Pedersen, C, Høfsten, D, Kløvgaard, L, Holmvang, L, Helqvist, S, Jørgensen, E, Galatius, S, Pedersen, F, Bang, L, Saunamaki, K, Clemmensen, P, Linde, JJ, Heitmann, M, Wendelboe Nielsen, O, Raymond, IE, Kristiansen, OP, Svendsen, IH, Bech, J, Dominguez Vall-Lamora, MH, Kragelund, C, Hansen, TF, Dahlgaard Hove, J, Jørgensen, T, Fornitz, GG, Steffensen, R, Jurlander, B, Abdulla, J, Lyngbæk, S, Elming, H, Therkelsen, SK, Abildgaard, U, Jensen, JS, Gislason, G, Køber, LV & Engstrøm, T 2018, 'Early Versus Standard Care Invasive Examination and Treatment of Patients With Non-ST-Segment Elevation Acute Coronary Syndrome', CIRCULATION, vol. 138, no. 24, pp. 2741-2750. https://doi.org/10.1161/CIRCULATIONAHA.118.037152

APA

Kofoed, K. F., Kelbæk, H., Hansen, P. R., Torp-Pedersen, C., Høfsten, D., Kløvgaard, L., Holmvang, L., Helqvist, S., Jørgensen, E., Galatius, S., Pedersen, F., Bang, L., Saunamaki, K., Clemmensen, P., Linde, J. J., Heitmann, M., Wendelboe Nielsen, O., Raymond, I. E., Kristiansen, O. P., ... Engstrøm, T. (2018). Early Versus Standard Care Invasive Examination and Treatment of Patients With Non-ST-Segment Elevation Acute Coronary Syndrome. CIRCULATION, 138(24), 2741-2750. https://doi.org/10.1161/CIRCULATIONAHA.118.037152

Vancouver

Kofoed KF, Kelbæk H, Hansen PR, Torp-Pedersen C, Høfsten D, Kløvgaard L et al. Early Versus Standard Care Invasive Examination and Treatment of Patients With Non-ST-Segment Elevation Acute Coronary Syndrome. CIRCULATION. 2018 Dec 11;138(24):2741-2750. https://doi.org/10.1161/CIRCULATIONAHA.118.037152

Bibtex

@article{0ec16895f1fe4e548d085aa30212021c,
title = "Early Versus Standard Care Invasive Examination and Treatment of Patients With Non-ST-Segment Elevation Acute Coronary Syndrome",
abstract = "BACKGROUND: The optimal timing of invasive coronary angiography (ICA) and revascularization in patients with non-ST-segment elevation acute coronary syndrome is not well defined. We tested the hypothesis that a strategy of very early ICA and possible revascularization within 12 hours of diagnosis is superior to an invasive strategy performed within 48 to 72 hours in terms of clinical outcomes.METHODS: Patients admitted with clinical suspicion of non-ST-segment elevation acute coronary syndrome in the Capital Region of Copenhagen, Denmark, were screened for inclusion in the VERDICT trial (Very Early Versus Deferred Invasive Evaluation Using Computerized Tomography) ( ClinicalTrials.gov NCT02061891). Patients with ECG changes indicating new ischemia or elevated troponin, in whom ICA was clinically indicated and deemed logistically feasible within 12 hours, were randomized 1:1 to ICA within 12 hours or standard invasive care within 48 to 72 hours. The primary end point was a combination of all-cause death, nonfatal recurrent myocardial infarction, hospital admission for refractory myocardial ischemia, or hospital admission for heart failure.RESULTS: A total of 2147 patients were randomized; 1075 patients allocated to very early invasive evaluation had ICA performed at a median of 4.7 hours after randomization, whereas 1072 patients assigned to standard invasive care had ICA performed 61.6 hours after randomization. Among patients with significant coronary artery disease identified by ICA, coronary revascularization was performed in 88.4% (very early ICA) and 83.1% (standard invasive care). Within a median follow-up time of 4.3 (interquartile range, 4.1-4.4) years, the primary end point occurred in 296 (27.5%) of participants in the very early ICA group and 316 (29.5%) in the standard care group (hazard ratio, 0.92; 95% CI, 0.78-1.08). Among patients with a GRACE risk score (Global Registry of Acute Coronary Events) >140, a very early invasive treatment strategy improved the primary outcome compared with the standard invasive treatment (hazard ratio, 0.81; 95% CI, 0.67-1.01; P value for interaction=0.023).CONCLUSIONS: A strategy of very early invasive coronary evaluation does not improve overall long-term clinical outcome compared with an invasive strategy conducted within 2 to 3 days in patients with non-ST-segment elevation acute coronary syndrome. However, in patients with the highest risk, very early invasive therapy improves long-term outcomes.CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov . Unique identifier: NCT02061891.",
keywords = "Acute Coronary Syndrome/diagnosis, Aged, Coronary Angiography/methods, Female, Heart Arrest/etiology, Humans, Male, Middle Aged, Percutaneous Coronary Intervention/adverse effects, Proportional Hazards Models, Risk Factors, Time Factors, Treatment Outcome, Troponin/metabolism",
author = "Kofoed, {Klaus F} and Henning Kelb{\ae}k and Hansen, {Peter Riis} and Christian Torp-Pedersen and Dan H{\o}fsten and Lene Kl{\o}vgaard and Lene Holmvang and Steffen Helqvist and Erik J{\o}rgensen and S{\o}ren Galatius and Frants Pedersen and Lia Bang and Kari Saunamaki and Peter Clemmensen and Linde, {Jesper J} and Merete Heitmann and {Wendelboe Nielsen}, Olav and Raymond, {Ilan E} and Kristiansen, {Ole Peter} and Svendsen, {Ida Hastrup} and Jan Bech and {Dominguez Vall-Lamora}, {Maria Helena} and Charlotte Kragelund and Hansen, {Thomas Fritz} and {Dahlgaard Hove}, Jens and Tem J{\o}rgensen and Fornitz, {Gitte G} and Rolf Steffensen and Birgit Jurlander and Jawdat Abdulla and Stig Lyngb{\ae}k and Hanne Elming and Therkelsen, {Susette Krohn} and Ulrik Abildgaard and Jensen, {Jan Skov} and Gunnar Gislason and K{\o}ber, {Lars V} and Thomas Engstr{\o}m",
year = "2018",
month = dec,
day = "11",
doi = "10.1161/CIRCULATIONAHA.118.037152",
language = "English",
volume = "138",
pages = "2741--2750",
journal = "CIRCULATION",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "24",

}

RIS

TY - JOUR

T1 - Early Versus Standard Care Invasive Examination and Treatment of Patients With Non-ST-Segment Elevation Acute Coronary Syndrome

AU - Kofoed, Klaus F

AU - Kelbæk, Henning

AU - Hansen, Peter Riis

AU - Torp-Pedersen, Christian

AU - Høfsten, Dan

AU - Kløvgaard, Lene

AU - Holmvang, Lene

AU - Helqvist, Steffen

AU - Jørgensen, Erik

AU - Galatius, Søren

AU - Pedersen, Frants

AU - Bang, Lia

AU - Saunamaki, Kari

AU - Clemmensen, Peter

AU - Linde, Jesper J

AU - Heitmann, Merete

AU - Wendelboe Nielsen, Olav

AU - Raymond, Ilan E

AU - Kristiansen, Ole Peter

AU - Svendsen, Ida Hastrup

AU - Bech, Jan

AU - Dominguez Vall-Lamora, Maria Helena

AU - Kragelund, Charlotte

AU - Hansen, Thomas Fritz

AU - Dahlgaard Hove, Jens

AU - Jørgensen, Tem

AU - Fornitz, Gitte G

AU - Steffensen, Rolf

AU - Jurlander, Birgit

AU - Abdulla, Jawdat

AU - Lyngbæk, Stig

AU - Elming, Hanne

AU - Therkelsen, Susette Krohn

AU - Abildgaard, Ulrik

AU - Jensen, Jan Skov

AU - Gislason, Gunnar

AU - Køber, Lars V

AU - Engstrøm, Thomas

PY - 2018/12/11

Y1 - 2018/12/11

N2 - BACKGROUND: The optimal timing of invasive coronary angiography (ICA) and revascularization in patients with non-ST-segment elevation acute coronary syndrome is not well defined. We tested the hypothesis that a strategy of very early ICA and possible revascularization within 12 hours of diagnosis is superior to an invasive strategy performed within 48 to 72 hours in terms of clinical outcomes.METHODS: Patients admitted with clinical suspicion of non-ST-segment elevation acute coronary syndrome in the Capital Region of Copenhagen, Denmark, were screened for inclusion in the VERDICT trial (Very Early Versus Deferred Invasive Evaluation Using Computerized Tomography) ( ClinicalTrials.gov NCT02061891). Patients with ECG changes indicating new ischemia or elevated troponin, in whom ICA was clinically indicated and deemed logistically feasible within 12 hours, were randomized 1:1 to ICA within 12 hours or standard invasive care within 48 to 72 hours. The primary end point was a combination of all-cause death, nonfatal recurrent myocardial infarction, hospital admission for refractory myocardial ischemia, or hospital admission for heart failure.RESULTS: A total of 2147 patients were randomized; 1075 patients allocated to very early invasive evaluation had ICA performed at a median of 4.7 hours after randomization, whereas 1072 patients assigned to standard invasive care had ICA performed 61.6 hours after randomization. Among patients with significant coronary artery disease identified by ICA, coronary revascularization was performed in 88.4% (very early ICA) and 83.1% (standard invasive care). Within a median follow-up time of 4.3 (interquartile range, 4.1-4.4) years, the primary end point occurred in 296 (27.5%) of participants in the very early ICA group and 316 (29.5%) in the standard care group (hazard ratio, 0.92; 95% CI, 0.78-1.08). Among patients with a GRACE risk score (Global Registry of Acute Coronary Events) >140, a very early invasive treatment strategy improved the primary outcome compared with the standard invasive treatment (hazard ratio, 0.81; 95% CI, 0.67-1.01; P value for interaction=0.023).CONCLUSIONS: A strategy of very early invasive coronary evaluation does not improve overall long-term clinical outcome compared with an invasive strategy conducted within 2 to 3 days in patients with non-ST-segment elevation acute coronary syndrome. However, in patients with the highest risk, very early invasive therapy improves long-term outcomes.CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov . Unique identifier: NCT02061891.

AB - BACKGROUND: The optimal timing of invasive coronary angiography (ICA) and revascularization in patients with non-ST-segment elevation acute coronary syndrome is not well defined. We tested the hypothesis that a strategy of very early ICA and possible revascularization within 12 hours of diagnosis is superior to an invasive strategy performed within 48 to 72 hours in terms of clinical outcomes.METHODS: Patients admitted with clinical suspicion of non-ST-segment elevation acute coronary syndrome in the Capital Region of Copenhagen, Denmark, were screened for inclusion in the VERDICT trial (Very Early Versus Deferred Invasive Evaluation Using Computerized Tomography) ( ClinicalTrials.gov NCT02061891). Patients with ECG changes indicating new ischemia or elevated troponin, in whom ICA was clinically indicated and deemed logistically feasible within 12 hours, were randomized 1:1 to ICA within 12 hours or standard invasive care within 48 to 72 hours. The primary end point was a combination of all-cause death, nonfatal recurrent myocardial infarction, hospital admission for refractory myocardial ischemia, or hospital admission for heart failure.RESULTS: A total of 2147 patients were randomized; 1075 patients allocated to very early invasive evaluation had ICA performed at a median of 4.7 hours after randomization, whereas 1072 patients assigned to standard invasive care had ICA performed 61.6 hours after randomization. Among patients with significant coronary artery disease identified by ICA, coronary revascularization was performed in 88.4% (very early ICA) and 83.1% (standard invasive care). Within a median follow-up time of 4.3 (interquartile range, 4.1-4.4) years, the primary end point occurred in 296 (27.5%) of participants in the very early ICA group and 316 (29.5%) in the standard care group (hazard ratio, 0.92; 95% CI, 0.78-1.08). Among patients with a GRACE risk score (Global Registry of Acute Coronary Events) >140, a very early invasive treatment strategy improved the primary outcome compared with the standard invasive treatment (hazard ratio, 0.81; 95% CI, 0.67-1.01; P value for interaction=0.023).CONCLUSIONS: A strategy of very early invasive coronary evaluation does not improve overall long-term clinical outcome compared with an invasive strategy conducted within 2 to 3 days in patients with non-ST-segment elevation acute coronary syndrome. However, in patients with the highest risk, very early invasive therapy improves long-term outcomes.CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov . Unique identifier: NCT02061891.

KW - Acute Coronary Syndrome/diagnosis

KW - Aged

KW - Coronary Angiography/methods

KW - Female

KW - Heart Arrest/etiology

KW - Humans

KW - Male

KW - Middle Aged

KW - Percutaneous Coronary Intervention/adverse effects

KW - Proportional Hazards Models

KW - Risk Factors

KW - Time Factors

KW - Treatment Outcome

KW - Troponin/metabolism

U2 - 10.1161/CIRCULATIONAHA.118.037152

DO - 10.1161/CIRCULATIONAHA.118.037152

M3 - SCORING: Journal article

C2 - 30565996

VL - 138

SP - 2741

EP - 2750

JO - CIRCULATION

JF - CIRCULATION

SN - 0009-7322

IS - 24

ER -