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Early Variations in White Matter Microstructure and Depression Outcome in Adolescents With Subthreshold Depression

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Early Variations in White Matter Microstructure and Depression Outcome in Adolescents With Subthreshold Depression. / Vulser, Hélène; Paillère Martinot, Marie-Laure; Artiges, Eric; Miranda, Ruben; Penttilä, Jani; Grimmer, Yvonne; van Noort, Betteke M; Stringaris, Argyris; Struve, Maren; Fadai, Tahmine; Kappel, Viola; Goodman, Robert; Tzavara, Eleni; Massaad, Charbel; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Bromberg, Uli; Brühl, Rüdiger; Büchel, Christian; Cattrell, Anna; Conrod, Patricia; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Gallinat, Juergen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Nees, Frauke; Papadopoulos-Orfanos, Dimitri; Paus, Tomas; Poustka, Luise; Rodehacke, Sarah; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Martinot, Jean-Luc; Lemaitre, Hervé; IMAGEN Consortium.

In: AM J PSYCHIAT, Vol. 175, No. 12, 01.12.2018, p. 1255-1264.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Vulser, H, Paillère Martinot, M-L, Artiges, E, Miranda, R, Penttilä, J, Grimmer, Y, van Noort, BM, Stringaris, A, Struve, M, Fadai, T, Kappel, V, Goodman, R, Tzavara, E, Massaad, C, Banaschewski, T, Barker, GJ, Bokde, ALW, Bromberg, U, Brühl, R, Büchel, C, Cattrell, A, Conrod, P, Desrivières, S, Flor, H, Frouin, V, Gallinat, J, Garavan, H, Gowland, P, Heinz, A, Nees, F, Papadopoulos-Orfanos, D, Paus, T, Poustka, L, Rodehacke, S, Smolka, MN, Walter, H, Whelan, R, Schumann, G, Martinot, J-L, Lemaitre, H & IMAGEN Consortium 2018, 'Early Variations in White Matter Microstructure and Depression Outcome in Adolescents With Subthreshold Depression', AM J PSYCHIAT, vol. 175, no. 12, pp. 1255-1264. https://doi.org/10.1176/appi.ajp.2018.17070825

APA

Vulser, H., Paillère Martinot, M-L., Artiges, E., Miranda, R., Penttilä, J., Grimmer, Y., van Noort, B. M., Stringaris, A., Struve, M., Fadai, T., Kappel, V., Goodman, R., Tzavara, E., Massaad, C., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Bromberg, U., Brühl, R., ... IMAGEN Consortium (2018). Early Variations in White Matter Microstructure and Depression Outcome in Adolescents With Subthreshold Depression. AM J PSYCHIAT, 175(12), 1255-1264. https://doi.org/10.1176/appi.ajp.2018.17070825

Vancouver

Vulser H, Paillère Martinot M-L, Artiges E, Miranda R, Penttilä J, Grimmer Y et al. Early Variations in White Matter Microstructure and Depression Outcome in Adolescents With Subthreshold Depression. AM J PSYCHIAT. 2018 Dec 1;175(12):1255-1264. https://doi.org/10.1176/appi.ajp.2018.17070825

Bibtex

@article{e1358690adcc484faa99c58dce17095f,
title = "Early Variations in White Matter Microstructure and Depression Outcome in Adolescents With Subthreshold Depression",
abstract = "OBJECTIVE: White matter microstructure alterations have recently been associated with depressive episodes during adolescence, but it is unknown whether they predate depression. The authors investigated whether subthreshold depression in adolescence is associated with white matter microstructure variations and whether they relate to depression outcome.METHOD: Adolescents with subthreshold depression (N=96) and healthy control subjects (N=336) drawn from a community-based cohort were compared using diffusion tensor imaging and whole brain tract-based spatial statistics (TBSS) at age 14 to assess white matter microstructure. They were followed up at age 16 to assess depression. Probabilistic tractography was used to reconstruct white matter streamlines spreading from the regions identified in the TBSS analysis and along bundles implicated in emotion regulation, the uncinate fasciculus and the cingulum. The authors searched for mediating effects of white matter microstructure on the relationship between baseline subthreshold depression and depression at follow-up, and then explored the specificity of the findings.RESULTS: Lower fractional anisotropy (FA) and higher radial diffusivity were found in the anterior corpus callosum in the adolescents with subthreshold depression. Tractography analysis showed that they also had lower FA in the right cingulum streamlines, along with lower FA and higher mean diffusivity in tracts connecting the corpus callosum to the anterior cingulate cortex. The relation between subthreshold depression at baseline and depression at follow-up was mediated by FA values in the latter tracts, and lower FA values in those tracts distinctively predicted higher individual risk for depression.CONCLUSIONS: Early FA variations in tracts projecting from the corpus callosum to the anterior cingulate cortex may denote a higher risk of transition to depression in adolescents.",
author = "H{\'e}l{\`e}ne Vulser and {Paill{\`e}re Martinot}, Marie-Laure and Eric Artiges and Ruben Miranda and Jani Penttil{\"a} and Yvonne Grimmer and {van Noort}, {Betteke M} and Argyris Stringaris and Maren Struve and Tahmine Fadai and Viola Kappel and Robert Goodman and Eleni Tzavara and Charbel Massaad and Tobias Banaschewski and Barker, {Gareth J} and Bokde, {Arun L W} and Uli Bromberg and R{\"u}diger Br{\"u}hl and Christian B{\"u}chel and Anna Cattrell and Patricia Conrod and Sylvane Desrivi{\`e}res and Herta Flor and Vincent Frouin and Juergen Gallinat and Hugh Garavan and Penny Gowland and Andreas Heinz and Frauke Nees and Dimitri Papadopoulos-Orfanos and Tomas Paus and Luise Poustka and Sarah Rodehacke and Smolka, {Michael N} and Henrik Walter and Robert Whelan and Gunter Schumann and Jean-Luc Martinot and Herv{\'e} Lemaitre and {IMAGEN Consortium}",
year = "2018",
month = dec,
day = "1",
doi = "10.1176/appi.ajp.2018.17070825",
language = "English",
volume = "175",
pages = "1255--1264",
journal = "AM J PSYCHIAT",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "12",

}

RIS

TY - JOUR

T1 - Early Variations in White Matter Microstructure and Depression Outcome in Adolescents With Subthreshold Depression

AU - Vulser, Hélène

AU - Paillère Martinot, Marie-Laure

AU - Artiges, Eric

AU - Miranda, Ruben

AU - Penttilä, Jani

AU - Grimmer, Yvonne

AU - van Noort, Betteke M

AU - Stringaris, Argyris

AU - Struve, Maren

AU - Fadai, Tahmine

AU - Kappel, Viola

AU - Goodman, Robert

AU - Tzavara, Eleni

AU - Massaad, Charbel

AU - Banaschewski, Tobias

AU - Barker, Gareth J

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Brühl, Rüdiger

AU - Büchel, Christian

AU - Cattrell, Anna

AU - Conrod, Patricia

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Gallinat, Juergen

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Nees, Frauke

AU - Papadopoulos-Orfanos, Dimitri

AU - Paus, Tomas

AU - Poustka, Luise

AU - Rodehacke, Sarah

AU - Smolka, Michael N

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - Martinot, Jean-Luc

AU - Lemaitre, Hervé

AU - IMAGEN Consortium

PY - 2018/12/1

Y1 - 2018/12/1

N2 - OBJECTIVE: White matter microstructure alterations have recently been associated with depressive episodes during adolescence, but it is unknown whether they predate depression. The authors investigated whether subthreshold depression in adolescence is associated with white matter microstructure variations and whether they relate to depression outcome.METHOD: Adolescents with subthreshold depression (N=96) and healthy control subjects (N=336) drawn from a community-based cohort were compared using diffusion tensor imaging and whole brain tract-based spatial statistics (TBSS) at age 14 to assess white matter microstructure. They were followed up at age 16 to assess depression. Probabilistic tractography was used to reconstruct white matter streamlines spreading from the regions identified in the TBSS analysis and along bundles implicated in emotion regulation, the uncinate fasciculus and the cingulum. The authors searched for mediating effects of white matter microstructure on the relationship between baseline subthreshold depression and depression at follow-up, and then explored the specificity of the findings.RESULTS: Lower fractional anisotropy (FA) and higher radial diffusivity were found in the anterior corpus callosum in the adolescents with subthreshold depression. Tractography analysis showed that they also had lower FA in the right cingulum streamlines, along with lower FA and higher mean diffusivity in tracts connecting the corpus callosum to the anterior cingulate cortex. The relation between subthreshold depression at baseline and depression at follow-up was mediated by FA values in the latter tracts, and lower FA values in those tracts distinctively predicted higher individual risk for depression.CONCLUSIONS: Early FA variations in tracts projecting from the corpus callosum to the anterior cingulate cortex may denote a higher risk of transition to depression in adolescents.

AB - OBJECTIVE: White matter microstructure alterations have recently been associated with depressive episodes during adolescence, but it is unknown whether they predate depression. The authors investigated whether subthreshold depression in adolescence is associated with white matter microstructure variations and whether they relate to depression outcome.METHOD: Adolescents with subthreshold depression (N=96) and healthy control subjects (N=336) drawn from a community-based cohort were compared using diffusion tensor imaging and whole brain tract-based spatial statistics (TBSS) at age 14 to assess white matter microstructure. They were followed up at age 16 to assess depression. Probabilistic tractography was used to reconstruct white matter streamlines spreading from the regions identified in the TBSS analysis and along bundles implicated in emotion regulation, the uncinate fasciculus and the cingulum. The authors searched for mediating effects of white matter microstructure on the relationship between baseline subthreshold depression and depression at follow-up, and then explored the specificity of the findings.RESULTS: Lower fractional anisotropy (FA) and higher radial diffusivity were found in the anterior corpus callosum in the adolescents with subthreshold depression. Tractography analysis showed that they also had lower FA in the right cingulum streamlines, along with lower FA and higher mean diffusivity in tracts connecting the corpus callosum to the anterior cingulate cortex. The relation between subthreshold depression at baseline and depression at follow-up was mediated by FA values in the latter tracts, and lower FA values in those tracts distinctively predicted higher individual risk for depression.CONCLUSIONS: Early FA variations in tracts projecting from the corpus callosum to the anterior cingulate cortex may denote a higher risk of transition to depression in adolescents.

U2 - 10.1176/appi.ajp.2018.17070825

DO - 10.1176/appi.ajp.2018.17070825

M3 - SCORING: Journal article

C2 - 30111185

VL - 175

SP - 1255

EP - 1264

JO - AM J PSYCHIAT

JF - AM J PSYCHIAT

SN - 0002-953X

IS - 12

ER -