Early prediction of long-term cognitive impairment after cardiac arrest.

Jörn Prohl; Sebastian Bodenburg; Stephan Jeff Rustenbach

Early prediction of long-term cognitive impairment after cardiac arrest.

Standard

Early prediction of long-term cognitive impairment after cardiac arrest. / Prohl, Jörn; Bodenburg, Sebastian; Rustenbach, Stephan Jeff.

In: J INT NEUROPSYCH SOC, Vol. 15, No. 3, 3, 2009, p. 344-353.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Prohl, J, Bodenburg, S & Rustenbach, SJ 2009, 'Early prediction of long-term cognitive impairment after cardiac arrest.', J INT NEUROPSYCH SOC, vol. 15, no. 3, 3, pp. 344-353. <http://www.ncbi.nlm.nih.gov/pubmed/19402920?dopt=Citation>

APA

Prohl, J., Bodenburg, S., & Rustenbach, S. J. (2009). Early prediction of long-term cognitive impairment after cardiac arrest. J INT NEUROPSYCH SOC, 15(3), 344-353. [3]. http://www.ncbi.nlm.nih.gov/pubmed/19402920?dopt=Citation

Vancouver

Prohl J, Bodenburg S, Rustenbach SJ. Early prediction of long-term cognitive impairment after cardiac arrest. J INT NEUROPSYCH SOC. 2009;15(3):344-353. 3.

Bibtex

@article{78a899656ac647b7a9e93d75e0ba500b,

title = "Early prediction of long-term cognitive impairment after cardiac arrest.",

abstract = "This prospective study evaluated the prognostic value of early neurobiochemical markers, neuron-specific enolase and astroglial protein S-100B, for long-term cognitive outcome after cardiac arrest. Six months after admission of a cohort of 80 consecutive patients, 26 survivors were able to undergo a neuropsychological test battery. Survivors showed low test performances in attention, learning/memory, and executive functioning. Neuropsychological bedside screening during the first month significantly differentiated between patients with and without long-term cognitive impairment. The neurobiochemical marker S-100B at day 3 after admission was found to predict significant proportions of variance in specific cognitive domains (learning/memory and executive functioning). The results indicate that early neuropsychological assessment might help identify patients who run at risk of long-term neuropsychological dysfunction. This study also suggests that especially the protein S-100B provides valuable information on long-term cognitive outcomes. To understand the exact relationship, results have to be replicated in larger trials.",

keywords = "Adult, Humans, Male, Aged, Female, Middle Aged, Neuropsychological Tests, Cohort Studies, Regression Analysis, Predictive Value of Tests, Time Factors, ROC Curve, Retrospective Studies, Analysis of Variance, Mental Status Schedule, Learning/physiology, Visual Perception/physiology, Attention/physiology, Phosphopyruvate Hydratase/blood, Cognition Disorders/*diagnosis/*etiology/metabolism, Heart Arrest/*complications/metabolism, Motor Skills/physiology, Nerve Growth Factors/blood, Problem Solving/physiology, S100 Proteins/blood, Adult, Humans, Male, Aged, Female, Middle Aged, Neuropsychological Tests, Cohort Studies, Regression Analysis, Predictive Value of Tests, Time Factors, ROC Curve, Retrospective Studies, Analysis of Variance, Mental Status Schedule, Learning/physiology, Visual Perception/physiology, Attention/physiology, Phosphopyruvate Hydratase/blood, Cognition Disorders/*diagnosis/*etiology/metabolism, Heart Arrest/*complications/metabolism, Motor Skills/physiology, Nerve Growth Factors/blood, Problem Solving/physiology, S100 Proteins/blood",

author = "J{\"o}rn Prohl and Sebastian Bodenburg and Rustenbach, {Stephan Jeff}",

year = "2009",

language = "English",

volume = "15",

pages = "344--353",

journal = "J INT NEUROPSYCH SOC",

issn = "1355-6177",

publisher = "Cambridge University Press",

number = "3",

}

RIS

TY - JOUR

T1 - Early prediction of long-term cognitive impairment after cardiac arrest.

AU - Prohl, Jörn

AU - Bodenburg, Sebastian

AU - Rustenbach, Stephan Jeff

PY - 2009

Y1 - 2009

N2 - This prospective study evaluated the prognostic value of early neurobiochemical markers, neuron-specific enolase and astroglial protein S-100B, for long-term cognitive outcome after cardiac arrest. Six months after admission of a cohort of 80 consecutive patients, 26 survivors were able to undergo a neuropsychological test battery. Survivors showed low test performances in attention, learning/memory, and executive functioning. Neuropsychological bedside screening during the first month significantly differentiated between patients with and without long-term cognitive impairment. The neurobiochemical marker S-100B at day 3 after admission was found to predict significant proportions of variance in specific cognitive domains (learning/memory and executive functioning). The results indicate that early neuropsychological assessment might help identify patients who run at risk of long-term neuropsychological dysfunction. This study also suggests that especially the protein S-100B provides valuable information on long-term cognitive outcomes. To understand the exact relationship, results have to be replicated in larger trials.

AB - This prospective study evaluated the prognostic value of early neurobiochemical markers, neuron-specific enolase and astroglial protein S-100B, for long-term cognitive outcome after cardiac arrest. Six months after admission of a cohort of 80 consecutive patients, 26 survivors were able to undergo a neuropsychological test battery. Survivors showed low test performances in attention, learning/memory, and executive functioning. Neuropsychological bedside screening during the first month significantly differentiated between patients with and without long-term cognitive impairment. The neurobiochemical marker S-100B at day 3 after admission was found to predict significant proportions of variance in specific cognitive domains (learning/memory and executive functioning). The results indicate that early neuropsychological assessment might help identify patients who run at risk of long-term neuropsychological dysfunction. This study also suggests that especially the protein S-100B provides valuable information on long-term cognitive outcomes. To understand the exact relationship, results have to be replicated in larger trials.

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Neuropsychological Tests

KW - Cohort Studies

KW - Regression Analysis

KW - Predictive Value of Tests

KW - Time Factors

KW - ROC Curve

KW - Retrospective Studies

KW - Analysis of Variance

KW - Mental Status Schedule

KW - Learning/physiology

KW - Visual Perception/physiology

KW - Attention/physiology

KW - Phosphopyruvate Hydratase/blood

KW - Cognition Disorders/diagnosis/etiology/metabolism

KW - Heart Arrest/complications/metabolism

KW - Motor Skills/physiology

KW - Nerve Growth Factors/blood

KW - Problem Solving/physiology

KW - S100 Proteins/blood