Early intragraft inflammatory events of liver allografts leading to chronic rejection.
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Early intragraft inflammatory events of liver allografts leading to chronic rejection. / Lautenschlager, I; Nashan, Björn; Schlitt, H J; Ringe, B; Wonigeit, K; Pichlmayr, R.
In: TRANSPL INT, Vol. 8, No. 6, 6, 1995, p. 446-451.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Early intragraft inflammatory events of liver allografts leading to chronic rejection.
AU - Lautenschlager, I
AU - Nashan, Björn
AU - Schlitt, H J
AU - Ringe, B
AU - Wonigeit, K
AU - Pichlmayr, R
PY - 1995
Y1 - 1995
N2 - In this retrospective study, we have investigated the early intragraft inflammatory events of 12 liver allografts leading to chronic rejection. The cytological findings and clinical follow-up were analyzed in detail. Nine patients underwent at least one typical lymphoid activation of acute rejection, and three of them were treated more than once. Diagnosis of rejection was based on biopsy histology, cytology and liver dysfunction. In addition to the acute rejections, cytological analysis demonstrated in 11 of 12 grafts an unidentified lymphoid episode that differed from that of rejection. These lymphoid responses were associated with viral infections; cytomegalovirus (CMV) infection in 10 of 12 patients, hepatitis C virus (HCV) infection in 2 of 12 patients, 1 combined with CMV, and hepatitis B virus (HBV) infection in 1 patient. Graft dysfunction was still seen at the end of the follow-up. Thus, intragraft inflammation caused either by acute rejection or by viral infections may be involved in the induction of chronic rejection.
AB - In this retrospective study, we have investigated the early intragraft inflammatory events of 12 liver allografts leading to chronic rejection. The cytological findings and clinical follow-up were analyzed in detail. Nine patients underwent at least one typical lymphoid activation of acute rejection, and three of them were treated more than once. Diagnosis of rejection was based on biopsy histology, cytology and liver dysfunction. In addition to the acute rejections, cytological analysis demonstrated in 11 of 12 grafts an unidentified lymphoid episode that differed from that of rejection. These lymphoid responses were associated with viral infections; cytomegalovirus (CMV) infection in 10 of 12 patients, hepatitis C virus (HCV) infection in 2 of 12 patients, 1 combined with CMV, and hepatitis B virus (HBV) infection in 1 patient. Graft dysfunction was still seen at the end of the follow-up. Thus, intragraft inflammation caused either by acute rejection or by viral infections may be involved in the induction of chronic rejection.
M3 - SCORING: Zeitschriftenaufsatz
VL - 8
SP - 446
EP - 451
JO - TRANSPL INT
JF - TRANSPL INT
SN - 0934-0874
IS - 6
M1 - 6
ER -