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Early clinical experiences with the new influenza A (H1N1/09)

Standard

Early clinical experiences with the new influenza A (H1N1/09). / Winzer, Ralf; Kanig, Nicolas; Schneitler, Sophie; Reuter, Stefan; Jensen, Björn; Müller-Stöver, Irmela; Oh, Jun; Adams, Ortwin; Mayatepek, Ertan; Hengel, Hartmut; Schneitler, Heiko; Häussinger, Dieter.

In: DTSCH ARZTEBL INT, Vol. 106, No. 47, 11.2009, p. 770-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Winzer, R, Kanig, N, Schneitler, S, Reuter, S, Jensen, B, Müller-Stöver, I, Oh, J, Adams, O, Mayatepek, E, Hengel, H, Schneitler, H & Häussinger, D 2009, 'Early clinical experiences with the new influenza A (H1N1/09)', DTSCH ARZTEBL INT, vol. 106, no. 47, pp. 770-6. https://doi.org/10.3238/arztebl.2009.0770

APA

Winzer, R., Kanig, N., Schneitler, S., Reuter, S., Jensen, B., Müller-Stöver, I., Oh, J., Adams, O., Mayatepek, E., Hengel, H., Schneitler, H., & Häussinger, D. (2009). Early clinical experiences with the new influenza A (H1N1/09). DTSCH ARZTEBL INT, 106(47), 770-6. https://doi.org/10.3238/arztebl.2009.0770

Vancouver

Winzer R, Kanig N, Schneitler S, Reuter S, Jensen B, Müller-Stöver I et al. Early clinical experiences with the new influenza A (H1N1/09). DTSCH ARZTEBL INT. 2009 Nov;106(47):770-6. https://doi.org/10.3238/arztebl.2009.0770

Bibtex

@article{fde046a12e8c46aab0fd4ce84cdbf282,
title = "Early clinical experiences with the new influenza A (H1N1/09)",
abstract = "BACKGROUND: Because of ongoing person-to-person transmission of the disease, the World Health Organization has declared a phase 6 pandemic alert for the new type of influenza A (H1N1/09). This means that the spread of the disease must be closely monitored.METHODS: At the D{\"u}sseldorf University Hospital, patients with flu-like symptoms and their contacts have been tested for the new type of influenza A since April 2009.RESULTS: The first patients that tested positive for H1N1/09 were treated on 20 May 2009. By mid-September, 3372 persons underwent PCR testing of a sample obtained by deep nasal swabbing, and the results were positive in 450 (13.3%). 379 of these 450 infections, or 84.2%, had been contracted abroad. Most patients came to the hospital with flu-like symptoms within three days of becoming ill. An analysis of the first 60 patients revealed a median core temperature of 37.8 degrees C and a mildly elevated C-reactive protein concentration. All patients were treated with oseltamivir. Most of the initially symptomatic patients were asymptomatic again within 3 days; the median duration of treatment was 5 days. The median time to the first negative deep nasal swab was 4 days. No oseltamivir resistance has been found to date in our patient collective.CONCLUSION: The clinical manifestations of the new type of influenza were still mild in the patient population that we studied up to mid-September 2009. At that time, the second wave of the pandemic had not yet begun in Germany. At present, however, the number of cases acquired within the country is on the rise.",
keywords = "Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Child, Child, Preschool, Disease Outbreaks/statistics & numerical data, Female, Germany/epidemiology, Humans, Incidence, Infant, Infant, Newborn, Influenza A Virus, H1N1 Subtype, Influenza, Human/epidemiology, Male, Middle Aged, Population Surveillance, Risk Assessment/methods, Risk Factors, Young Adult",
author = "Ralf Winzer and Nicolas Kanig and Sophie Schneitler and Stefan Reuter and Bj{\"o}rn Jensen and Irmela M{\"u}ller-St{\"o}ver and Jun Oh and Ortwin Adams and Ertan Mayatepek and Hartmut Hengel and Heiko Schneitler and Dieter H{\"a}ussinger",
year = "2009",
month = nov,
doi = "10.3238/arztebl.2009.0770",
language = "English",
volume = "106",
pages = "770--6",
journal = "DTSCH ARZTEBL INT",
issn = "1866-0452",
publisher = "Deutscher Arzte-Verlag",
number = "47",

}

RIS

TY - JOUR

T1 - Early clinical experiences with the new influenza A (H1N1/09)

AU - Winzer, Ralf

AU - Kanig, Nicolas

AU - Schneitler, Sophie

AU - Reuter, Stefan

AU - Jensen, Björn

AU - Müller-Stöver, Irmela

AU - Oh, Jun

AU - Adams, Ortwin

AU - Mayatepek, Ertan

AU - Hengel, Hartmut

AU - Schneitler, Heiko

AU - Häussinger, Dieter

PY - 2009/11

Y1 - 2009/11

N2 - BACKGROUND: Because of ongoing person-to-person transmission of the disease, the World Health Organization has declared a phase 6 pandemic alert for the new type of influenza A (H1N1/09). This means that the spread of the disease must be closely monitored.METHODS: At the Düsseldorf University Hospital, patients with flu-like symptoms and their contacts have been tested for the new type of influenza A since April 2009.RESULTS: The first patients that tested positive for H1N1/09 were treated on 20 May 2009. By mid-September, 3372 persons underwent PCR testing of a sample obtained by deep nasal swabbing, and the results were positive in 450 (13.3%). 379 of these 450 infections, or 84.2%, had been contracted abroad. Most patients came to the hospital with flu-like symptoms within three days of becoming ill. An analysis of the first 60 patients revealed a median core temperature of 37.8 degrees C and a mildly elevated C-reactive protein concentration. All patients were treated with oseltamivir. Most of the initially symptomatic patients were asymptomatic again within 3 days; the median duration of treatment was 5 days. The median time to the first negative deep nasal swab was 4 days. No oseltamivir resistance has been found to date in our patient collective.CONCLUSION: The clinical manifestations of the new type of influenza were still mild in the patient population that we studied up to mid-September 2009. At that time, the second wave of the pandemic had not yet begun in Germany. At present, however, the number of cases acquired within the country is on the rise.

AB - BACKGROUND: Because of ongoing person-to-person transmission of the disease, the World Health Organization has declared a phase 6 pandemic alert for the new type of influenza A (H1N1/09). This means that the spread of the disease must be closely monitored.METHODS: At the Düsseldorf University Hospital, patients with flu-like symptoms and their contacts have been tested for the new type of influenza A since April 2009.RESULTS: The first patients that tested positive for H1N1/09 were treated on 20 May 2009. By mid-September, 3372 persons underwent PCR testing of a sample obtained by deep nasal swabbing, and the results were positive in 450 (13.3%). 379 of these 450 infections, or 84.2%, had been contracted abroad. Most patients came to the hospital with flu-like symptoms within three days of becoming ill. An analysis of the first 60 patients revealed a median core temperature of 37.8 degrees C and a mildly elevated C-reactive protein concentration. All patients were treated with oseltamivir. Most of the initially symptomatic patients were asymptomatic again within 3 days; the median duration of treatment was 5 days. The median time to the first negative deep nasal swab was 4 days. No oseltamivir resistance has been found to date in our patient collective.CONCLUSION: The clinical manifestations of the new type of influenza were still mild in the patient population that we studied up to mid-September 2009. At that time, the second wave of the pandemic had not yet begun in Germany. At present, however, the number of cases acquired within the country is on the rise.

KW - Adolescent

KW - Adult

KW - Age Distribution

KW - Aged

KW - Aged, 80 and over

KW - Child

KW - Child, Preschool

KW - Disease Outbreaks/statistics & numerical data

KW - Female

KW - Germany/epidemiology

KW - Humans

KW - Incidence

KW - Infant

KW - Infant, Newborn

KW - Influenza A Virus, H1N1 Subtype

KW - Influenza, Human/epidemiology

KW - Male

KW - Middle Aged

KW - Population Surveillance

KW - Risk Assessment/methods

KW - Risk Factors

KW - Young Adult

U2 - 10.3238/arztebl.2009.0770

DO - 10.3238/arztebl.2009.0770

M3 - SCORING: Journal article

C2 - 20019861

VL - 106

SP - 770

EP - 776

JO - DTSCH ARZTEBL INT

JF - DTSCH ARZTEBL INT

SN - 1866-0452

IS - 47

ER -