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Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence

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Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence. / French, Leon; Gray, Courtney; Leonard, Gabriel; Perron, Michel; Pike, G Bruce; Richer, Louis; Séguin, Jean R; Veillette, Suzanne; Evans, C John; Artiges, Eric; Banaschewski, Tobias; Bokde, Arun W L; Bromberg, Uli; Bruehl, Ruediger; Buchel, Christian; Cattrell, Anna; Conrod, Patricia J; Flor, Herta; Frouin, Vincent; Gallinat, Jurgen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Lemaitre, Herve; Martinot, Jean-Luc; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Pangelinan, Melissa Marie; Poustka, Luise; Rietschel, Marcella; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Timpson, Nic J; Schumann, Gunter; Smith, George Davey; Pausova, Zdenka; Paus, Tomáš.

In: JAMA PSYCHIAT, Vol. 72, No. 10, 10.2015, p. 1002-11.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

French, L, Gray, C, Leonard, G, Perron, M, Pike, GB, Richer, L, Séguin, JR, Veillette, S, Evans, CJ, Artiges, E, Banaschewski, T, Bokde, AWL, Bromberg, U, Bruehl, R, Buchel, C, Cattrell, A, Conrod, PJ, Flor, H, Frouin, V, Gallinat, J, Garavan, H, Gowland, P, Heinz, A, Lemaitre, H, Martinot, J-L, Nees, F, Orfanos, DP, Pangelinan, MM, Poustka, L, Rietschel, M, Smolka, MN, Walter, H, Whelan, R, Timpson, NJ, Schumann, G, Smith, GD, Pausova, Z & Paus, T 2015, 'Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence', JAMA PSYCHIAT, vol. 72, no. 10, pp. 1002-11. https://doi.org/10.1001/jamapsychiatry.2015.1131

APA

French, L., Gray, C., Leonard, G., Perron, M., Pike, G. B., Richer, L., Séguin, J. R., Veillette, S., Evans, C. J., Artiges, E., Banaschewski, T., Bokde, A. W. L., Bromberg, U., Bruehl, R., Buchel, C., Cattrell, A., Conrod, P. J., Flor, H., Frouin, V., ... Paus, T. (2015). Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence. JAMA PSYCHIAT, 72(10), 1002-11. https://doi.org/10.1001/jamapsychiatry.2015.1131

Vancouver

French L, Gray C, Leonard G, Perron M, Pike GB, Richer L et al. Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence. JAMA PSYCHIAT. 2015 Oct;72(10):1002-11. https://doi.org/10.1001/jamapsychiatry.2015.1131

Bibtex

@article{e8badc3942cb4ffb8e25481995bdc0d2,
title = "Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence",
abstract = "IMPORTANCE: Cannabis use during adolescence is known to increase the risk for schizophrenia in men. Sex differences in the dynamics of brain maturation during adolescence may be of particular importance with regard to vulnerability of the male brain to cannabis exposure.OBJECTIVE: To evaluate whether the association between cannabis use and cortical maturation in adolescents is moderated by a polygenic risk score for schizophrenia.DESIGN, SETTING, AND PARTICIPANTS: Observation of 3 population-based samples included initial analysis in 1024 adolescents of both sexes from the Canadian Saguenay Youth Study (SYS) and follow-up in 426 adolescents of both sexes from the IMAGEN Study from 8 European cities and 504 male youth from the Avon Longitudinal Study of Parents and Children (ALSPAC) based in England. A total of 1577 participants (aged 12-21 years; 899 [57.0%] male) had (1) information about cannabis use; (2) imaging studies of the brain; and (3) a polygenic risk score for schizophrenia across 108 genetic loci identified by the Psychiatric Genomics Consortium. Data analysis was performed from March 1 through December 31, 2014.MAIN OUTCOMES AND MEASURES: Cortical thickness derived from T1-weighted magnetic resonance images. Linear regression tests were used to assess the relationships between cannabis use, cortical thickness, and risk score.RESULTS: Across the 3 samples of 1574 participants, a negative association was observed between cannabis use in early adolescence and cortical thickness in male participants with a high polygenic risk score. This observation was not the case for low-risk male participants or for the low- or high-risk female participants. Thus, in SYS male participants, cannabis use interacted with risk score vis-{\`a}-vis cortical thickness (P = .009); higher scores were associated with lower thickness only in males who used cannabis. Similarly, in the IMAGEN male participants, cannabis use interacted with increased risk score vis-{\`a}-vis a change in decreasing cortical thickness from 14.5 to 18.5 years of age (t137 = -2.36; P = .02). Finally, in the ALSPAC high-risk group of male participants, those who used cannabis most frequently (≥61 occasions) had lower cortical thickness than those who never used cannabis (difference in cortical thickness, 0.07 [95% CI, 0.01-0.12]; P = .02) and those with light use (<5 occasions) (difference in cortical thickness, 0.11 [95% CI, 0.03-0.18]; P = .004).CONCLUSIONS AND RELEVANCE: Cannabis use in early adolescence moderates the association between the genetic risk for schizophrenia and cortical maturation among male individuals. This finding implicates processes underlying cortical maturation in mediating the link between cannabis use and liability to schizophrenia.",
author = "Leon French and Courtney Gray and Gabriel Leonard and Michel Perron and Pike, {G Bruce} and Louis Richer and S{\'e}guin, {Jean R} and Suzanne Veillette and Evans, {C John} and Eric Artiges and Tobias Banaschewski and Bokde, {Arun W L} and Uli Bromberg and Ruediger Bruehl and Christian Buchel and Anna Cattrell and Conrod, {Patricia J} and Herta Flor and Vincent Frouin and Jurgen Gallinat and Hugh Garavan and Penny Gowland and Andreas Heinz and Herve Lemaitre and Jean-Luc Martinot and Frauke Nees and Orfanos, {Dimitri Papadopoulos} and Pangelinan, {Melissa Marie} and Luise Poustka and Marcella Rietschel and Smolka, {Michael N} and Henrik Walter and Robert Whelan and Timpson, {Nic J} and Gunter Schumann and Smith, {George Davey} and Zdenka Pausova and Tom{\'a}{\v s} Paus",
year = "2015",
month = oct,
doi = "10.1001/jamapsychiatry.2015.1131",
language = "English",
volume = "72",
pages = "1002--11",
journal = "JAMA PSYCHIAT",
issn = "2168-622X",
publisher = "American Medical Association",
number = "10",

}

RIS

TY - JOUR

T1 - Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence

AU - French, Leon

AU - Gray, Courtney

AU - Leonard, Gabriel

AU - Perron, Michel

AU - Pike, G Bruce

AU - Richer, Louis

AU - Séguin, Jean R

AU - Veillette, Suzanne

AU - Evans, C John

AU - Artiges, Eric

AU - Banaschewski, Tobias

AU - Bokde, Arun W L

AU - Bromberg, Uli

AU - Bruehl, Ruediger

AU - Buchel, Christian

AU - Cattrell, Anna

AU - Conrod, Patricia J

AU - Flor, Herta

AU - Frouin, Vincent

AU - Gallinat, Jurgen

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Lemaitre, Herve

AU - Martinot, Jean-Luc

AU - Nees, Frauke

AU - Orfanos, Dimitri Papadopoulos

AU - Pangelinan, Melissa Marie

AU - Poustka, Luise

AU - Rietschel, Marcella

AU - Smolka, Michael N

AU - Walter, Henrik

AU - Whelan, Robert

AU - Timpson, Nic J

AU - Schumann, Gunter

AU - Smith, George Davey

AU - Pausova, Zdenka

AU - Paus, Tomáš

PY - 2015/10

Y1 - 2015/10

N2 - IMPORTANCE: Cannabis use during adolescence is known to increase the risk for schizophrenia in men. Sex differences in the dynamics of brain maturation during adolescence may be of particular importance with regard to vulnerability of the male brain to cannabis exposure.OBJECTIVE: To evaluate whether the association between cannabis use and cortical maturation in adolescents is moderated by a polygenic risk score for schizophrenia.DESIGN, SETTING, AND PARTICIPANTS: Observation of 3 population-based samples included initial analysis in 1024 adolescents of both sexes from the Canadian Saguenay Youth Study (SYS) and follow-up in 426 adolescents of both sexes from the IMAGEN Study from 8 European cities and 504 male youth from the Avon Longitudinal Study of Parents and Children (ALSPAC) based in England. A total of 1577 participants (aged 12-21 years; 899 [57.0%] male) had (1) information about cannabis use; (2) imaging studies of the brain; and (3) a polygenic risk score for schizophrenia across 108 genetic loci identified by the Psychiatric Genomics Consortium. Data analysis was performed from March 1 through December 31, 2014.MAIN OUTCOMES AND MEASURES: Cortical thickness derived from T1-weighted magnetic resonance images. Linear regression tests were used to assess the relationships between cannabis use, cortical thickness, and risk score.RESULTS: Across the 3 samples of 1574 participants, a negative association was observed between cannabis use in early adolescence and cortical thickness in male participants with a high polygenic risk score. This observation was not the case for low-risk male participants or for the low- or high-risk female participants. Thus, in SYS male participants, cannabis use interacted with risk score vis-à-vis cortical thickness (P = .009); higher scores were associated with lower thickness only in males who used cannabis. Similarly, in the IMAGEN male participants, cannabis use interacted with increased risk score vis-à-vis a change in decreasing cortical thickness from 14.5 to 18.5 years of age (t137 = -2.36; P = .02). Finally, in the ALSPAC high-risk group of male participants, those who used cannabis most frequently (≥61 occasions) had lower cortical thickness than those who never used cannabis (difference in cortical thickness, 0.07 [95% CI, 0.01-0.12]; P = .02) and those with light use (<5 occasions) (difference in cortical thickness, 0.11 [95% CI, 0.03-0.18]; P = .004).CONCLUSIONS AND RELEVANCE: Cannabis use in early adolescence moderates the association between the genetic risk for schizophrenia and cortical maturation among male individuals. This finding implicates processes underlying cortical maturation in mediating the link between cannabis use and liability to schizophrenia.

AB - IMPORTANCE: Cannabis use during adolescence is known to increase the risk for schizophrenia in men. Sex differences in the dynamics of brain maturation during adolescence may be of particular importance with regard to vulnerability of the male brain to cannabis exposure.OBJECTIVE: To evaluate whether the association between cannabis use and cortical maturation in adolescents is moderated by a polygenic risk score for schizophrenia.DESIGN, SETTING, AND PARTICIPANTS: Observation of 3 population-based samples included initial analysis in 1024 adolescents of both sexes from the Canadian Saguenay Youth Study (SYS) and follow-up in 426 adolescents of both sexes from the IMAGEN Study from 8 European cities and 504 male youth from the Avon Longitudinal Study of Parents and Children (ALSPAC) based in England. A total of 1577 participants (aged 12-21 years; 899 [57.0%] male) had (1) information about cannabis use; (2) imaging studies of the brain; and (3) a polygenic risk score for schizophrenia across 108 genetic loci identified by the Psychiatric Genomics Consortium. Data analysis was performed from March 1 through December 31, 2014.MAIN OUTCOMES AND MEASURES: Cortical thickness derived from T1-weighted magnetic resonance images. Linear regression tests were used to assess the relationships between cannabis use, cortical thickness, and risk score.RESULTS: Across the 3 samples of 1574 participants, a negative association was observed between cannabis use in early adolescence and cortical thickness in male participants with a high polygenic risk score. This observation was not the case for low-risk male participants or for the low- or high-risk female participants. Thus, in SYS male participants, cannabis use interacted with risk score vis-à-vis cortical thickness (P = .009); higher scores were associated with lower thickness only in males who used cannabis. Similarly, in the IMAGEN male participants, cannabis use interacted with increased risk score vis-à-vis a change in decreasing cortical thickness from 14.5 to 18.5 years of age (t137 = -2.36; P = .02). Finally, in the ALSPAC high-risk group of male participants, those who used cannabis most frequently (≥61 occasions) had lower cortical thickness than those who never used cannabis (difference in cortical thickness, 0.07 [95% CI, 0.01-0.12]; P = .02) and those with light use (<5 occasions) (difference in cortical thickness, 0.11 [95% CI, 0.03-0.18]; P = .004).CONCLUSIONS AND RELEVANCE: Cannabis use in early adolescence moderates the association between the genetic risk for schizophrenia and cortical maturation among male individuals. This finding implicates processes underlying cortical maturation in mediating the link between cannabis use and liability to schizophrenia.

U2 - 10.1001/jamapsychiatry.2015.1131

DO - 10.1001/jamapsychiatry.2015.1131

M3 - SCORING: Journal article

C2 - 26308966

VL - 72

SP - 1002

EP - 1011

JO - JAMA PSYCHIAT

JF - JAMA PSYCHIAT

SN - 2168-622X

IS - 10

ER -